format-version: 1.0
date: 14:02:2007 18:36
saved-by: stuart
auto-generated-by: Protege OBO-Converter version 1.0
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: goslim_goa "GOA and proteome slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
remark: cvs version: $Revision: 4.149 $
default-namespace: file:/Users/stuart/Desktop/FirefoxDownloads/component.obo

[Term]
id: GO:0000015
name: phosphopyruvate hydratase complex
namespace: cellular_component
def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
exact_synonym: "enolase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000108
name: repairosome
namespace: cellular_component
def: "A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000109
name: nucleotide-excision repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862]
comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000110
name: nucleotide-excision repair factor 1 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
exact_synonym: "NEF1 complex" []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000111
name: nucleotide-excision repair factor 2 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
exact_synonym: "NEF2 complex" []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000112
name: nucleotide-excision repair factor 3 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
exact_synonym: "NEF3 complex" []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000113
name: nucleotide-excision repair factor 4 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
exact_synonym: "NEF4 complex" []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000118
name: histone deacetylase complex
namespace: cellular_component
def: "Complex that possesses histone deacetylase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.
exact_synonym: "HDAC complex" []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000119
name: mediator complex
namespace: cellular_component
def: "A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription." [PMID:10384286, PMID:11114191, PMID:8187178, PMID:9396788, PMID:9774831]
narrow_synonym: "TRAP complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0000120
name: RNA polymerase I transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0000123
name: histone acetyltransferase complex
namespace: cellular_component
def: "Complex that possesses histone acetyltransferase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
exact_synonym: "histone acetylase complex" []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000124
name: SAGA complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607]
exact_synonym: "Spt-Ada-Gcn5-acetyltransferase complex" []
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0000125
name: PCAF complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0000126
name: transcription factor TFIIIB complex
namespace: cellular_component
def: "A transcription factor for eukaryotic RNA polymerase III promoters that is an RNA polymerase binding protein." [GOC:mah, ISBN:0198547684]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000127
name: transcription factor TFIIIC complex
namespace: cellular_component
def: "A heterotrimeric transcription factor for eukaryotic RNA polymerase III promoters." [GOC:mah, ISBN:0198547684]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000131
name: incipient bud site
namespace: cellular_component
def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000133
name: polarisome
namespace: cellular_component
def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790]
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030427 ! site of polarized growth

[Term]
id: GO:0000136
name: alpha-1,6-mannosyltransferase complex
namespace: cellular_component
def: "A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735]
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0000137 ! Golgi cis cisterna

[Term]
id: GO:0000137
name: Golgi cis cisterna
namespace: cellular_component
def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000138
name: Golgi trans cisterna
namespace: cellular_component
def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000139
name: Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044425 ! membrane part
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0000142
name: bud neck contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis." [GOC:krc, PMID:16009555]
exact_synonym: "contractile ring (sensu Saccharomyces)" []
exact_synonym: "neck ring" []
broad_synonym: "actomyosin ring (sensu Saccharomyces)" []
broad_synonym: "cytokinetic ring (sensu Saccharomyces)" []
is_a: GO:0005826 ! contractile ring
relationship: part_of GO:0005935 ! bud neck

[Term]
id: GO:0000144
name: bud neck septin ring
namespace: cellular_component
def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555]
exact_synonym: "septin ring (sensu Saccharomyces)" []
is_a: GO:0000399 ! bud neck septin structure
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure

[Term]
id: GO:0000145
name: exocyst
namespace: cellular_component
def: "Protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0000148
name: 1,3-beta-glucan synthase complex
namespace: cellular_component
def: "The complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain." [EC:2.4.1.34]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0000151
name: ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex." [PMID:9529603]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000152
name: nuclear ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000153
name: cytoplasmic ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000159
name: protein phosphatase type 2A complex
namespace: cellular_component
def: "A heterodimer with protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic and regulatory subunits." [GOC:mah, ISBN:0198547684]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000164
name: protein phosphatase type 1 complex
namespace: cellular_component
def: "An ATP, magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa, which is subject to phosphorylation, thus activating the phosphatase." [GOC:mah, ISBN:0198547684]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000172
name: ribonuclease MRP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that performs the first cleavage in rRNA transcript processing and is also involved in mitochondrial RNA processing." [PMID:10690410]
exact_synonym: "ribonuclease mitochondrial RNA processing complex" []
exact_synonym: "RNase MRP complex" []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0000176
name: nuclear exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000177
name: cytoplasmic exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791]
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000178
name: exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases." [PMID:10465791]
comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000180
name: cytosolic large ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist. To update annotations, consider the cellular component terms 'cytosolic large ribosomal subunit (sensu Bacteria) ; GO:0009282' and 'cytosolic large ribosomal subunit (sensu Eukaryota) ; GO:0005842'.
is_obsolete: true

[Term]
id: GO:0000181
name: cytosolic small ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist. To update annotations, consider the cellular component terms 'cytosolic small ribosomal subunit (sensu Bacteria) ; GO:0009283' and 'cytosolic small ribosomal subunit (sensu Eukaryota) ; GO:0005843'.
is_obsolete: true

[Term]
id: GO:0000214
name: tRNA-intron endonuclease complex
namespace: cellular_component
def: "A complex that catalyses the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000219
name: vacuolar hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created. To update annotations, consider the cellular component term 'proton-transporting two-sector ATPase complex ; GO:0016469' and its children.
exact_synonym: "V-ATPase" []
is_obsolete: true

[Term]
id: GO:0000220
name: hydrogen-transporting ATPase V0 domain
namespace: cellular_component
def: "The integral domain of the V-type ATPase comprises the pore through the membrane, through which protons are translocated." [GOC:rb, PMID:10224039, TC:3.A.2.-.-]
comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit.
is_a: GO:0016471 ! hydrogen-translocating V-type ATPase complex

[Term]
id: GO:0000221
name: hydrogen-transporting ATPase V1 domain
namespace: cellular_component
def: "The peripheral domain of the V-type ATPase contains the section responsible for ATP hydrolysis." [GOC:rb, PMID:10224039, TC:3.A.2.-.-]
comment: Note that this domain generally consists of eight subunits.
is_a: GO:0016471 ! hydrogen-translocating V-type ATPase complex

[Term]
id: GO:0000222
name: plasma membrane hydrogen-transporting ATPase V0 domain
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0000223
name: plasma membrane hydrogen-transporting ATPase V1 domain
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0000228
name: nuclear chromosome
namespace: cellular_component
def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah]
subset: goslim_generic
narrow_synonym: "nuclear interphase chromosome" []
is_a: GO:0005694 ! chromosome
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000229
name: cytoplasmic chromosome
namespace: cellular_component
def: "A chromosome found in the cytoplasm." [GOC:mah]
subset: goslim_generic
subset: gosubset_prok
narrow_synonym: "cytoplasmic interphase chromosome" []
is_a: GO:0005694 ! chromosome
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000230
name: nuclear mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider the cellular component term 'condensed nuclear chromosome ; GO:0000794'.
is_obsolete: true

[Term]
id: GO:0000231
name: cytoplasmic mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider the cellular component term 'condensed chromosome ; GO:0000793'.
is_obsolete: true

[Term]
id: GO:0000232
name: nuclear interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider the cellular component term 'nuclear chromosome ; GO:0000228'.
is_obsolete: true

[Term]
id: GO:0000233
name: cytoplasmic interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider the cellular component term 'cytoplasmic chromosome ; GO:0000229'.
is_obsolete: true

[Term]
id: GO:0000235
name: astral microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
is_a: GO:0005876 ! spindle microtubule
relationship: part_of GO:0005818 ! aster

[Term]
id: GO:0000242
name: pericentriolar material
namespace: cellular_component
def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0000243
name: commitment complex
namespace: cellular_component
def: "The first portion of the spliceosome to assemble in mRNA splicing; in commitment complex formation the 5' and 3' splice sites are recognized by the U1 snRNP and the U2 snRNP auxiliary factor, respectively." [PMID:9159080]
exact_synonym: "E complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005681 ! spliceosome complex

[Term]
id: GO:0000262
name: mitochondrial chromosome
namespace: cellular_component
def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah]
related_synonym: "mitochondrial genome" []
narrow_synonym: "mitochondrial DNA" []
narrow_synonym: "mtDNA" []
is_a: GO:0005694 ! chromosome
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0042645 ! mitochondrial nucleoid

[Term]
id: GO:0000267
name: cell fraction
namespace: cellular_component
def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000274
name: proton-transporting ATP synthase, stator stalk (sensu Eukaryota)
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [PMID:10838056]
exact_synonym: "hydrogen-transporting ATP synthase, stator stalk (sensu Eukaryota)" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk
relationship: part_of GO:0000276 ! proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota)

[Term]
id: GO:0000275
name: proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota)
namespace: cellular_component
def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [PMID:10838056]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
broad_synonym: "hydrogen-transporting ATP synthase, F1 sector" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
relationship: part_of GO:0005753 ! proton-transporting ATP synthase complex (sensu Eukaryota)

[Term]
id: GO:0000276
name: proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota)
namespace: cellular_component
def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [PMID:10838056]
exact_synonym: "proton-transporting ATP synthase complex, coupling factor F(0) (sensu Eukaryota)" []
broad_synonym: "hydrogen-transporting ATP synthase, F0 sector" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
relationship: part_of GO:0005753 ! proton-transporting ATP synthase complex (sensu Eukaryota)

[Term]
id: GO:0000299
name: integral to membrane of membrane fraction
namespace: cellular_component
def: "Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0000300
name: peripheral to membrane of membrane fraction
namespace: cellular_component
def: "Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0000306
name: extrinsic to vacuolar membrane
namespace: cellular_component
def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0000307
name: cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]
exact_synonym: "CDK holoenzyme" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000308
name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc]
broad_synonym: "CDK holoenzyme" []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000311
name: plastid large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000312
name: plastid small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc]
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000313
name: organellar ribosome
namespace: cellular_component
def: "A ribosome contained within a subcellular organelle." [GOC:mcc]
is_a: GO:0005840 ! ribosome

[Term]
id: GO:0000314
name: organellar small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc]
is_a: GO:0015935 ! small ribosomal subunit
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000315
name: organellar large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0015934 ! large ribosomal subunit
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000322
name: storage vacuole
namespace: cellular_component
def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000323
name: lytic vacuole
namespace: cellular_component
def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000324
name: vacuole (sensu Fungi)
namespace: cellular_component
def: "The vacuole is a large, membrane-bound organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649]
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0000325
name: vacuole (sensu Magnoliophyta)
namespace: cellular_component
def: "Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [ISBN:0815316208]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000326
name: protein storage vacuole
namespace: cellular_component
def: "A compound organelle of plants where there is a lytic vacuole within a storage vacuole." [PMID:11739409]
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000325 ! vacuole (sensu Magnoliophyta)

[Term]
id: GO:0000327
name: lytic vacuole within protein storage vacuole
namespace: cellular_component
def: "A membrane-bound compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490]
is_a: GO:0000323 ! lytic vacuole
is_a: GO:0000326 ! protein storage vacuole

[Term]
id: GO:0000328
name: vacuolar lumen (sensu Fungi)
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of the vacuole. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:krc]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000324 ! vacuole (sensu Fungi)

[Term]
id: GO:0000329
name: vacuolar membrane (sensu Fungi)
namespace: cellular_component
def: "The lipid bilayer separating the vacuole from the cytoplasm of the cell. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:krc]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000324 ! vacuole (sensu Fungi)

[Term]
id: GO:0000330
name: vacuolar lumen (sensu Magnoliophyta)
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:krc]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000325 ! vacuole (sensu Magnoliophyta)

[Term]
id: GO:0000331
name: contractile vacuole
namespace: cellular_component
def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:10503189]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000333
name: telomerase catalytic core complex
namespace: cellular_component
def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619]
is_a: GO:0005697 ! telomerase holoenzyme complex

[Term]
id: GO:0000343
name: plastid-encoded plastid RNA polymerase complex A
namespace: cellular_component
def: "The plastid-encoded plastid RNA polymerase A (PEP-A) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105]
exact_synonym: "PEP-A" []
is_a: GO:0030880 ! RNA polymerase complex
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0000344
name: plastid-encoded plastid RNA polymerase complex B
namespace: cellular_component
def: "The plastid-encoded plastid RNA polymerase B (PEP-B) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105]
exact_synonym: "PEP-B" []
is_a: GO:0030880 ! RNA polymerase complex
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0000345
name: cytosolic DNA-directed RNA polymerase (sensu Bacteria)
namespace: cellular_component
def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:11158566]
subset: gosubset_prok
is_a: GO:0030880 ! RNA polymerase complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000346
name: transcription export complex
namespace: cellular_component
def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277]
exact_synonym: "TREX complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000347
name: THO complex
namespace: cellular_component
def: "The THO complex is an oligomeric complex, primarily located in the nucleus, that is involved in transcription elongation by RNA polymerase II and is crucial for transcription of certain coding regions. The complex, though not each of the individual subunits, is found in a range of eukaryotic organisms, from S. cerevisiae to metazoans." [GOC:krc, PMID:11060033]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0000346 ! transcription export complex

[Term]
id: GO:0000399
name: bud neck septin structure
namespace: cellular_component
def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc]
is_a: GO:0032155 ! cell division site part
relationship: part_of GO:0005935 ! bud neck

[Term]
id: GO:0000407
name: pre-autophagosomal structure
namespace: cellular_component
def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
exact_synonym: "PAS" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000408
name: EKC/KEOPS protein complex
namespace: cellular_component
def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308]
exact_synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" []
exact_synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000417
name: HIR complex
namespace: cellular_component
def: "A protein complex proposed to be involved in replication-indepdent chromatin assembly. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, PMID:16303565]
is_a: GO:0005678 ! chromatin assembly complex

[Term]
id: GO:0000418
name: DNA-directed RNA polymerase IV complex
namespace: cellular_component
def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The IVa and IVb complexes contain different forms of the largest subunit. The remainder of the complex is composed of smaller subunits." [GOC:krc, PMID:15692015, PMID:15766525, PMID:16140984]
is_a: GO:0030880 ! RNA polymerase complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0000419
name: DNA-directed RNA polymerase IVb complex
namespace: cellular_component
def: "RNA polymerase IVb is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, PMID:16140984]
is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex

[Term]
id: GO:0000420
name: DNA-directed RNA polymerase IVa complex
namespace: cellular_component
def: "RNA polymerase IVa is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVb, while the largest subunit is found only in the IVa complex. The remainder of the complex is composed of smaller subunits." [GOC:krc, PMID:15692015, PMID:15766525, PMID:16140984]
is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex

[Term]
id: GO:0000500
name: RNA polymerase I upstream activating factor complex
namespace: cellular_component
def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378]
broad_synonym: "UAF" []
is_a: GO:0000120 ! RNA polymerase I transcription factor complex

[Term]
id: GO:0000502
name: proteasome complex (sensu Eukaryota)
namespace: cellular_component
def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and the regulatory particle that caps the proteasome core complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:rb]
narrow_synonym: "26S proteasome" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000503
name: proteasome core complex (sensu Bacteria)
namespace: cellular_component
def: "A multisubunit, barrel shaped protease complex. This complex consists of fourteen subunits of two distinct but related polypeptides. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb]
subset: gosubset_prok
narrow_synonym: "26S proteasome" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000504
name: proteasome regulatory particle (sensu Bacteria)
namespace: cellular_component
def: "A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb]
subset: gosubset_prok
narrow_synonym: "26S proteasome" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000506
name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411]
comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity.
exact_synonym: "GPI-GlcNAc transferase complex" []
exact_synonym: "GPI-GnT complex" []
exact_synonym: "GPI-N-acetylglucosaminyltransferase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0000508
name: Rpd3L complex
namespace: cellular_component
def: "A multisubunit histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p." [GOC:rb, PMID:16286008, PMID:16314178]
exact_synonym: "Rpd3C(L)" []
is_a: GO:0000118 ! histone deacetylase complex

[Term]
id: GO:0000509
name: Rpd3S complex
namespace: cellular_component
def: "A multisubunit histone deacetylase complex that is involved in intragenic transcription repression through histone deacetylation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3.\n" [GOC:rb, PMID:16286007, PMID:16286008]
exact_synonym: "Rpd3C(S)" []
is_a: GO:0000118 ! histone deacetylase complex

[Term]
id: GO:0000775
name: chromosome, pericentric region
namespace: cellular_component
def: "The central region of a chromosome that includes the centromere and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
related_synonym: "centromere" []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000776
name: kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
related_synonym: "kinetochore motor activity" []
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, pericentric region

[Term]
id: GO:0000777
name: condensed chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the pericentric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000776 ! kinetochore
relationship: part_of GO:0000779 ! condensed chromosome, pericentric region

[Term]
id: GO:0000778
name: condensed nuclear chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the pericentric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000777 ! condensed chromosome kinetochore
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000780 ! condensed nuclear chromosome, pericentric region

[Term]
id: GO:0000779
name: condensed chromosome, pericentric region
namespace: cellular_component
def: "The central region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore." [GOC:elh]
comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
related_synonym: "condensed chromosome, centromere" []
is_a: GO:0000775 ! chromosome, pericentric region
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000780
name: condensed nuclear chromosome, pericentric region
namespace: cellular_component
def: "The central region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore." [GOC:elh]
comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
related_synonym: "condensed nuclear chromosome, centromere" []
is_a: GO:0000779 ! condensed chromosome, pericentric region
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000781
name: chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
related_synonym: "telomere" []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000782
name: telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
related_synonym: "telomere" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0000783
name: nuclear telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
is_a: GO:0000782 ! telomere cap complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region

[Term]
id: GO:0000784
name: nuclear chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
exact_synonym: "nuclear chromosome, telomere" []
is_a: GO:0000781 ! chromosome, telomeric region
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000785
name: chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms the chromosome." [GOC:elh]
related_synonym: "chromosome scaffold" []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000786
name: nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0000787
name: cytoplasmic nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000789 ! cytoplasmic chromatin

[Term]
id: GO:0000788
name: nuclear nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0000789
name: cytoplasmic chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms the chromosome in the cytoplasm." [GOC:elh]
is_a: GO:0000785 ! chromatin
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0000790
name: nuclear chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus." [GOC:elh]
is_a: GO:0000785 ! chromatin
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000791
name: euchromatin
namespace: cellular_component
def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000792
name: heterochromatin
namespace: cellular_component
def: "A compact and highly condensed form of chromatin." [GOC:elh]
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000793
name: condensed chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis.
related_synonym: "chromatid" []
related_synonym: "cytoplasmic mitotic chromosome" []
related_synonym: "metaphase chromosome" []
related_synonym: "mitotic chromosome" []
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000794
name: condensed nuclear chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh]
comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome.
related_synonym: "chromatid" []
related_synonym: "meiotic chromosome" []
related_synonym: "metaphase chromosome" []
related_synonym: "mitotic chromosome" []
related_synonym: "nuclear mitotic chromosome" []
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000793 ! condensed chromosome

[Term]
id: GO:0000795
name: synaptonemal complex
namespace: cellular_component
def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000796
name: condensin complex
namespace: cellular_component
def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
related_synonym: "SMC complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000797
name: condensin core heterodimer
namespace: cellular_component
def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
narrow_synonym: "Smc2-Smc4 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000796 ! condensin complex

[Term]
id: GO:0000798
name: nuclear cohesin complex
namespace: cellular_component
def: "A protein complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh]
is_a: GO:0008278 ! cohesin complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000799
name: nuclear condensin complex
namespace: cellular_component
def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh]
is_a: GO:0000796 ! condensin complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000800
name: lateral element
namespace: cellular_component
def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh]
related_synonym: "axial element" []
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000801
name: central element
namespace: cellular_component
def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000802
name: transverse filament
namespace: cellular_component
def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000803
name: sex chromosome
namespace: cellular_component
def: "A chromosome involved in sex determination." [GOC:elh]
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000804
name: W chromosome
namespace: cellular_component
def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382]
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000805
name: X chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089]
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000806
name: Y chromosome
namespace: cellular_component
def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089]
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000807
name: Z chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382]
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000808
name: origin recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
subset: gosubset_prok
exact_synonym: "ORC" []
exact_synonym: "origin of replication recognition complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000809
name: cytoplasmic origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh]
subset: gosubset_prok
related_synonym: "prokaryotic ORC" []
exact_synonym: "cytoplasmic ORC" []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0000811
name: GINS complex
namespace: cellular_component
def: "A multisubunit complex that associates with replication origins and is required for the initiation of DNA replication." [GOC:rn, PMID:12730134]
exact_synonym: "Go, Ichi, Ni and San complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000812
name: SWR1 complex
namespace: cellular_component
def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [PMID:14645854, PMID:14690608]
exact_synonym: "SWR-C" []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0000813
name: ESCRT I complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
broad_synonym: "Endosomal Sorting Complex Required for Transport" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000814
name: ESCRT II complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
broad_synonym: "Endosomal Sorting Complex Required for Transport" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000815
name: ESCRT III complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
broad_synonym: "Endosomal Sorting Complex Required for Transport" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000817
name: COMA complex
namespace: cellular_component
def: "A multiprotein complex in yeast consisting of Ctf1p, Okp1p, Mcm1p, Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972]
exact_synonym: "Ctf1p-Okp1p-Mcm1p-Ame1p complex" []
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000818
name: MIND complex
namespace: cellular_component
def: "A multiprotein complex in yeast consisting of Mtw1p, Nnf1p, Nsl1p, and Dsn1. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972]
exact_synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" []
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000922
name: spindle pole
namespace: cellular_component
def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0000923
name: equatorial microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817]
exact_synonym: "EMTOC" []
exact_synonym: "equatorial microtubule organising centre" []
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0032155 ! cell division site part

[Term]
id: GO:0000924
name: gamma-tubulin ring complex, centrosomal
namespace: cellular_component
def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, PMID:12134075]
is_a: GO:0008274 ! gamma-tubulin ring complex

[Term]
id: GO:0000925
name: gamma-tubulin ring complex, centrosomal (sensu Metazoa)
namespace: cellular_component
def: "A multiprotein complex that composed of approximately 10-14 gamma-tubulin molecules and at least six other non-tubulin proteins assembled into a flexible open ring structure, which in animal cells has a diameter of around 25nm. It is thought to be the unit of nucleation at the minus end of a microtubule. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [PMID:12134075]
is_a: GO:0000924 ! gamma-tubulin ring complex, centrosomal

[Term]
id: GO:0000926
name: gamma-tubulin large complex (sensu Metazoa)
namespace: cellular_component
def: "A complex thought to be formed by multimerization of gamma-tubulin small complexes. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [PMID:12134075]
is_a: GO:0000931 ! gamma-tubulin large complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0000925 ! gamma-tubulin ring complex, centrosomal (sensu Metazoa)

[Term]
id: GO:0000927
name: gamma-tubulin small complex (sensu Metazoa)
namespace: cellular_component
def: "A complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [PMID:12134075]
is_a: GO:0008275 ! gamma-tubulin small complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0000925 ! gamma-tubulin ring complex, centrosomal (sensu Metazoa)

[Term]
id: GO:0000928
name: gamma-tubulin complex (sensu Saccharomyces)
namespace: cellular_component
def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:12134075]
exact_synonym: "Tub4 complex" []
is_a: GO:0008275 ! gamma-tubulin small complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0000929
name: gamma-tubulin large complex (sensu Schizosaccharomyces)
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other conserved non-tubulin proteins. Complex size is heterogenous but is around 2000kDa (or greater than 20S) and is comparable to the vertebrate gamma-tubulin large complex. As in, but not restricted to, the taxon Schizosaccharomyces (Schizosaccharomyces, ncbi_taxonomy_id:4895)." [PMID:12134075]
is_a: GO:0000931 ! gamma-tubulin large complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0000923 ! equatorial microtubule organizing center
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0000930
name: gamma-tubulin complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]
is_a: GO:0043234 ! protein complex
is_a: GO:0044450 ! microtubule organizing center part

[Term]
id: GO:0000931
name: gamma-tubulin large complex
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes." [PMID:12134075]
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0000932
name: cytoplasmic mRNA processing body
namespace: cellular_component
def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
exact_synonym: "P body" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000933
name: adventitious septum
namespace: cellular_component
def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526]
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000934
name: porous cell septum
namespace: cellular_component
def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt]
broad_synonym: "porous septum" []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000935
name: barrier septum
namespace: cellular_component
def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt]
exact_synonym: "complete septum" []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000936
name: primary cell septum
namespace: cellular_component
def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526]
broad_synonym: "primary septum" []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000937
name: dolipore septum
namespace: cellular_component
def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt]
is_a: GO:0000934 ! porous cell septum

[Term]
id: GO:0000938
name: GARP complex
namespace: cellular_component
def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]
exact_synonym: "Golgi associated retrograde protein complex" []
exact_synonym: "VFT tethering complex" []
exact_synonym: "Vps fifty three tethering complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0000939
name: inner kinetochore of condensed chromosome
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983]
related_synonym: "inner centromere core complex" []
narrow_synonym: "inner kinetochore plate" []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000940
name: outer kinetochore of condensed chromosome
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
narrow_synonym: "outer kinetochore plate" []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000941
name: inner kinetochore of condensed nuclear chromosome
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398]
is_a: GO:0000939 ! inner kinetochore of condensed chromosome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000942
name: outer kinetochore of condensed nuclear chromosome
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398]
is_a: GO:0000940 ! outer kinetochore of condensed chromosome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000943
name: retrotransposon nucleocapsid
namespace: cellular_component
def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903]
exact_synonym: "Virus-like particle" []
exact_synonym: "VLP" []
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0001400
name: mating projection base
namespace: cellular_component
def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc]
related_synonym: "shmoo" []
narrow_synonym: "base of shmoo tip" []
narrow_synonym: "conjugation tube base" []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0001401
name: mitochondrial sorting and assembly machinery complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]
comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'.
exact_synonym: "SAM complex" []
exact_synonym: "TOB complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0001405
name: presequence translocase-associated import motor
namespace: cellular_component
def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855]
exact_synonym: "mitochondrial import motor" []
exact_synonym: "PAM complex" []
exact_synonym: "pre-sequence translocase-associated import motor" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex

[Term]
id: GO:0001411
name: hyphal tip
namespace: cellular_component
def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc]
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0001518
name: voltage-gated sodium channel complex
namespace: cellular_component
def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732]
exact_synonym: "voltage gated sodium channel complex" []
exact_synonym: "voltage-dependent sodium channel complex" []
exact_synonym: "voltage-sensitive sodium channel complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0001520
name: outer dense fiber
namespace: cellular_component
def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820]
exact_synonym: "outer dense fibre" []
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0001527
name: microfibril
namespace: cellular_component
def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235]
related_synonym: "fibrillin" []
exact_synonym: "extended fibrils" []
is_a: GO:0043205 ! fibril

[Term]
id: GO:0001529
name: elastin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product. To update annotations, use the molecular function term 'extracellular matrix constituent conferring elasticity ; GO:0030023'.
is_obsolete: true

[Term]
id: GO:0001533
name: cornified envelope
namespace: cellular_component
def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0001534
name: radial spoke
namespace: cellular_component
def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0001535
name: radial spokehead
namespace: cellular_component
def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001536
name: radial spoke stalk
namespace: cellular_component
def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001650
name: fibrillar center
namespace: cellular_component
def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561]
exact_synonym: "fibrillar centre" []
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001651
name: dense fibrillar component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561]
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001652
name: granular component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561]
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001669
name: acrosome
namespace: cellular_component
def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plama membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0001673
name: male germ cell nucleus
namespace: cellular_component
def: "The nucleus of a male germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:hjd, http://cancerweb.ncl.ac.uk]
exact_synonym: "male germ-cell nucleus" []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001674
name: female germ cell nucleus
namespace: cellular_component
def: "The nucleus of the female germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:hjd, http://cancerweb.ncl.ac.uk]
exact_synonym: "female germ-cell nucleus" []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001683
name: axonemal dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'axonemal dynein complex ; GO:0005858'.
is_obsolete: true

[Term]
id: GO:0001684
name: axonemal dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'axonemal dynein complex ; GO:0005858'.
is_obsolete: true

[Term]
id: GO:0001685
name: axonemal dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'axonemal dynein complex ; GO:0005858'.
is_obsolete: true

[Term]
id: GO:0001686
name: axonemal dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'axonemal dynein complex ; GO:0005858'.
is_obsolete: true

[Term]
id: GO:0001687
name: cytoplasmic dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'cytoplasmic dynein complex ; GO:0005868'.
is_obsolete: true

[Term]
id: GO:0001688
name: cytoplasmic dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'cytoplasmic dynein complex ; GO:0005868'.
is_obsolete: true

[Term]
id: GO:0001689
name: cytoplasmic dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'cytoplasmic dynein complex ; GO:0005868'.
is_obsolete: true

[Term]
id: GO:0001690
name: cytoplasmic dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'cytoplasmic dynein complex ; GO:0005868'.
is_obsolete: true

[Term]
id: GO:0001721
name: intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'intermediate filament ; GO:0005882'.
exact_synonym: "IFAP" []
is_obsolete: true

[Term]
id: GO:0001722
name: type I intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'intermediate filament ; GO:0005882'.
is_obsolete: true

[Term]
id: GO:0001723
name: type II intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'intermediate filament ; GO:0005882'.
is_obsolete: true

[Term]
id: GO:0001724
name: type III intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'type III intermediate filament ; GO:0045098'.
is_obsolete: true

[Term]
id: GO:0001725
name: stress fiber
namespace: cellular_component
def: "Bundle of microfilaments and other proteins found in fibroblasts." [ISBN:0124325653]
exact_synonym: "stress fibre" []
is_a: GO:0032432 ! actin filament bundle

[Term]
id: GO:0001726
name: ruffle
namespace: cellular_component
def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
related_synonym: "membrane ruffle" []
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031252 ! leading edge

[Term]
id: GO:0001739
name: sex chromatin
namespace: cellular_component
def: "A condensed mass of chromatin that represents an inactivated X chromosome." [ISBN:0198506732]
is_a: GO:0005720 ! nuclear heterochromatin
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0001740
name: Barr body
namespace: cellular_component
def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd]
is_a: GO:0000805 ! X chromosome
is_a: GO:0001739 ! sex chromatin

[Term]
id: GO:0001741
name: XY body
namespace: cellular_component
def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd]
is_a: GO:0001739 ! sex chromatin

[Term]
id: GO:0001750
name: photoreceptor outer segment
namespace: cellular_component
def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820]
is_a: GO:0031513 ! nonmotile primary cilium

[Term]
id: GO:0001772
name: immunological synapse
namespace: cellular_component
def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated lipid rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001891
name: phagocytic cup
namespace: cellular_component
def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001917
name: photoreceptor inner segment
namespace: cellular_component
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0001931
name: uropod
namespace: cellular_component
def: "A rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated, found on the opposite side of the cell from the lamellipodium or immunological synapse, respectively." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750]
related_synonym: "distal pole complex" []
related_synonym: "retractile pole" []
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031254 ! trailing edge

[Term]
id: GO:0001939
name: female pronucleus
namespace: cellular_component
def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001940
name: male pronucleus
namespace: cellular_component
def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001950
name: PME fraction
namespace: cellular_component
def: "The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832]
is_a: GO:0000267 ! cell fraction
relationship: part_of GO:0005624 ! membrane fraction

[Term]
id: GO:0002079
name: inner acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405]
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002080
name: acrosomal membrane
namespace: cellular_component
def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0001669 ! acrosome

[Term]
id: GO:0002081
name: outer acrosomal membrane
namespace: cellular_component
def: "The acrosomal region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405]
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0003675
name: protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005559
name: ribozyme
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005561
name: nucleic acid
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005562
name: RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005564
name: cytosolic tRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005565
name: mitochondrial tRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005567
name: cytosolic ribosomal RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005568
name: mitochondrial rRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005571
name: untranslated RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005572
name: RNA polymerase II transcribed untranslated RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005573
name: telomerase RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a gene product. To update annotations, use the molecular function term 'template for synthesis of G-rich strand of telomere DNA activity ; GO:0000332'.
is_obsolete: true

[Term]
id: GO:0005574
name: DNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators]
comment: Note that this term should be used for the annotation of gene products whose cellular component is unknown by annotating to this node with the evidence code ND, no data.
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
narrow_synonym: "cellular component unknown" []

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface.
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
exact_synonym: "extracellular" []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005577
name: fibrinogen complex
namespace: cellular_component
def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684]
exact_synonym: "fibrinogen" []
narrow_synonym: "fibrinogen alpha chain" []
narrow_synonym: "fibrinogen beta chain" []
narrow_synonym: "fibrinogen gamma chain" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005578
name: extracellular matrix (sensu Metazoa)
namespace: cellular_component
def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
narrow_synonym: "adhesive extracellular matrix constituent" []
is_a: GO:0031012 ! extracellular matrix
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0005579
name: membrane attack complex
namespace: cellular_component
def: "A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [ISBN:0198547684, ISBN:068340007X, ISBN:0781735149]
exact_synonym: "MAC" []
exact_synonym: "TCC" []
exact_synonym: "terminal complement complex" []
narrow_synonym: "membrane attack complex protein alphaM chain" []
narrow_synonym: "membrane attack complex protein beta2 chain" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! extracellular matrix (sensu Metazoa)

[Term]
id: GO:0005580
name: membrane attack complex protein alphaM chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'membrane attack complex ; GO:0005579'.
is_obsolete: true

[Term]
id: GO:0005581
name: collagen
namespace: cellular_component
def: "Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976]
related_synonym: "other collagen" []
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! extracellular matrix (sensu Metazoa)

[Term]
id: GO:0005582
name: collagen type XV
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes." [PMID:11158616, PMID:11937714]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0005583
name: fibrillar collagen
namespace: cellular_component
def: "Any collagen polymer in which collagen triple helices associate to form fibrils." [GOC:mah, ISBN:0721639976]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0005584
name: collagen type I
namespace: cellular_component
def: "A collagen heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; type I collagen triple helices associate to form banded fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005585
name: collagen type II
namespace: cellular_component
def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005586
name: collagen type III
namespace: cellular_component
def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005587
name: collagen type IV
namespace: cellular_component
def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes." [ISBN:0721639976]
is_a: GO:0030935 ! sheet-forming collagen
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0005588
name: collagen type V
namespace: cellular_component
def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005589
name: collagen type VI
namespace: cellular_component
def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976]
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0005590
name: collagen type VII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue." [ISBN:0721639976]
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0005591
name: collagen type VIII
namespace: cellular_component
def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976]
is_a: GO:0005598 ! short-chain collagen

[Term]
id: GO:0005592
name: collagen type XI
namespace: cellular_component
def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005593
name: FACIT collagen
namespace: cellular_component
def: "Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix." [ISBN:0198599587]
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0005594
name: collagen type IX
namespace: cellular_component
def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005595
name: collagen type XII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005596
name: collagen type XIV
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005597
name: collagen type XVI
namespace: cellular_component
def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005598
name: short-chain collagen
namespace: cellular_component
def: "Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens." [ISBN:0198599587]
is_a: GO:0030935 ! sheet-forming collagen

[Term]
id: GO:0005599
name: collagen type X
namespace: cellular_component
def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets." [ISBN:0721639976]
is_a: GO:0005598 ! short-chain collagen

[Term]
id: GO:0005600
name: collagen type XIII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes." [ISBN:0721639976]
is_a: GO:0030936 ! transmembrane collagen

[Term]
id: GO:0005601
name: classical-complement-pathway C3/C5 convertase complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005602
name: complement component C1q complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005603
name: complement component C2 complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005604
name: basement membrane
namespace: cellular_component
def: "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! extracellular matrix (sensu Metazoa)

[Term]
id: GO:0005605
name: basal lamina
namespace: cellular_component
def: "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]
exact_synonym: "basement lamina" []
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0005606
name: laminin-1 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha1, beta1 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005607
name: laminin-2 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016011 ! dystroglycan complex

[Term]
id: GO:0005608
name: laminin-3 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha1, beta2 and gamma1." [MEDLINE:95005761]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005609
name: laminin-4 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta2 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005610
name: laminin-5 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha3, beta3 and gamma2." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005611
name: laminin-6 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha3, beta1 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005612
name: laminin-7 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha3, beta2 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005613
name: laminin receptor protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. To update annotations, consider the cellular component term 'integrin complex ; GO:0008305'.
is_obsolete: true

[Term]
id: GO:0005614
name: interstitial matrix
namespace: cellular_component
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0005615
name: extracellular space
namespace: cellular_component
def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
related_synonym: "intercellular space" []
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0005616
name: larval serum protein complex
namespace: cellular_component
def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, UniProtKB:P11995]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005617
name: larval serum protein-1
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
exact_synonym: "LSP1" []
is_obsolete: true

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0005619
name: spore wall (sensu Fungi)
namespace: cellular_component
def: "The specialized cell wall of the ascospore (spore). As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693568]
is_a: GO:0009277 ! cell wall (sensu Fungi)
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0005620
name: periplasmic space
namespace: cellular_component
def: "OBSOLETE. The region in a bacterial or yeast cell between the cell membrane and the cell wall." [ISBN:0198547684]
comment: This term was made obsolete because it was defined inaccurately. To update annotations, consider the cellular component terms 'periplasmic space (sensu Proteobacteria) ; GO:0030288' or 'periplasmic space (sensu Fungi) ; GO:0030287'.
is_obsolete: true

[Term]
id: GO:0005621
name: bud scar
namespace: cellular_component
def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! cell wall (sensu Fungi)

[Term]
id: GO:0005622
name: intracellular
namespace: cellular_component
def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
exact_synonym: "protoplasm" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005623
name: cell
namespace: cellular_component
def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005624
name: membrane fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0000267 ! cell fraction

[Term]
id: GO:0005625
name: soluble fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
broad_synonym: "soluble" []
is_a: GO:0000267 ! cell fraction

[Term]
id: GO:0005626
name: insoluble fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
related_synonym: "particle-bound" []
is_a: GO:0000267 ! cell fraction

[Term]
id: GO:0005627
name: ascus
namespace: cellular_component
def: "OBSOLETE. A sac-like fruiting body (ascomycete fungi); contains ascospores (typically eight in number)." [ISBN:0198547684]
comment: This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider the term 'ascus ; FAO:0000014' in the Fungal Gross Anatomy ontology.
is_obsolete: true

[Term]
id: GO:0005628
name: prospore membrane
namespace: cellular_component
def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls." [ISBN:0879693649]
exact_synonym: "forespore membrane (sensu Fungi)" []
exact_synonym: "FSM" []
is_a: GO:0016020 ! membrane
relationship: part_of GO:0042764 ! prospore

[Term]
id: GO:0005630
name: dityrosine layer of spore wall
namespace: cellular_component
def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! spore wall (sensu Fungi)

[Term]
id: GO:0005631
name: chitosan layer of spore wall
namespace: cellular_component
def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! spore wall (sensu Fungi)

[Term]
id: GO:0005632
name: inner layer of spore wall
namespace: cellular_component
def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! spore wall (sensu Fungi)

[Term]
id: GO:0005633
name: ascus lipid droplet
namespace: cellular_component
def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293]
is_a: GO:0005811 ! lipid particle

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: goslim_yeast
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0005635
name: nuclear envelope
namespace: cellular_component
alt_id: GO:0005636
def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_plant
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005637
name: nuclear inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]
broad_synonym: "inner envelope" []
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031965 ! nuclear membrane
is_a: GO:0044453 ! nuclear membrane part

[Term]
id: GO:0005638
name: lamin filament
namespace: cellular_component
def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684]
exact_synonym: "type V intermediate filament" []
is_a: GO:0005882 ! intermediate filament
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005637 ! nuclear inner membrane
relationship: part_of GO:0005652 ! nuclear lamina

[Term]
id: GO:0005639
name: integral to nuclear inner membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
is_a: GO:0031229 ! intrinsic to nuclear inner membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0005640
name: nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]
exact_synonym: "perinuclear membrane" []
broad_synonym: "outer envelope" []
is_a: GO:0031965 ! nuclear membrane
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network

[Term]
id: GO:0005641
name: nuclear envelope lumen
namespace: cellular_component
alt_id: GO:0005653
def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai]
comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
related_synonym: "nuclear membrane lumen" []
exact_synonym: "nuclear intermembrane space" []
exact_synonym: "perinuclear space" []
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044453 ! nuclear membrane part

[Term]
id: GO:0005642
name: annulate lamellae
namespace: cellular_component
def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728]
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network

[Term]
id: GO:0005643
name: nuclear pore
namespace: cellular_component
alt_id: GO:0005644
def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
exact_synonym: "NPC" []
exact_synonym: "nuclear pore complex" []
narrow_synonym: "nuclear pore membrane protein" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044453 ! nuclear membrane part
is_a: GO:0046930 ! pore complex

[Term]
id: GO:0005645
name: RAN-binding protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the molecular function term 'Ran GTPase binding ; GO:0008536' and consider the cellular component terms 'nucleus ; GO:0005634', 'cytoplasm ; GO:0005737', and 'nuclear pore ; GO:0005643' and its children.
is_obsolete: true

[Term]
id: GO:0005646
name: importin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component terms 'nucleus ; GO:0005634', 'cytoplasm ; GO:0005737', and 'nuclear pore ; GO:0005643' and its children.
exact_synonym: "karyopherin" []
is_obsolete: true

[Term]
id: GO:0005647
name: importin, alpha-subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component terms 'nucleus ; GO:0005634', 'cytoplasm ; GO:0005737', and 'nuclear pore ; GO:0005643' and its children.
exact_synonym: "karyopherin-alpha" []
is_obsolete: true

[Term]
id: GO:0005648
name: importin, beta-subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component terms 'nucleus ; GO:0005634', 'cytoplasm ; GO:0005737', and 'nuclear pore ; GO:0005643' and its children.
exact_synonym: "karyopherin-beta1" []
is_obsolete: true

[Term]
id: GO:0005649
name: transportin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component terms 'nucleus ; GO:0005634', 'cytoplasm ; GO:0005737', and 'nuclear pore ; GO:0005643' and its children.
exact_synonym: "karyopherin-beta2" []
is_obsolete: true

[Term]
id: GO:0005650
name: importin, alpha-subunit transport factor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component terms 'nucleus ; GO:0005634', 'cytoplasm ; GO:0005737', and 'nuclear pore ; GO:0005643' and its children.
related_synonym: "CAS" []
is_obsolete: true

[Term]
id: GO:0005651
name: exportin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component terms 'nucleus ; GO:0005634', 'cytoplasm ; GO:0005737', and 'nuclear pore ; GO:0005643' and its children.
is_obsolete: true

[Term]
id: GO:0005652
name: nuclear lamina
namespace: cellular_component
def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0005654
name: nucleoplasm
namespace: cellular_component
def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
subset: goslim_generic
subset: goslim_plant
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005655
name: nucleolar ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
exact_synonym: "nucleolar RNase P complex" []
is_a: GO:0030681 ! multimeric ribonuclease P complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0005656
name: pre-replicative complex
namespace: cellular_component
def: "A multiprotein complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894]
exact_synonym: "pre-RC" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005657
name: replication fork
namespace: cellular_component
def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
related_synonym: "replication focus" []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0005658
name: alpha DNA polymerase:primase complex
namespace: cellular_component
def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]
related_synonym: "pol-prim" []
exact_synonym: "DNA polymerase alpha:primase complex" []
exact_synonym: "heterotetrameric polymerase alpha holoenzyme" []
broad_synonym: "primosome" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! replisome (sensu Eukaryota)

[Term]
id: GO:0005659
name: delta DNA polymerase complex
namespace: cellular_component
def: "OBSOLETE. A multimeric enzyme complex, which in humans is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa. Also includes the delta DNA polymerase cofactor. Functions in DNA replication, mismatch repair and excision repair." [ISBN:0198547684, PMID:11205330, PMID:12403614]
comment: This term was made obsolete because it was erroneously defined as including the delta DNA polymerase cofactor (now also obsolete) which consisted of the complexes PCNA and Replication factor C (RFC), when in fact these are not bona fide subunits of the delta DNA polymerase complex. Several annotations of PNCA and RFC proteins had been made to this term, which is why it was necessary to obsolete it and create a new one. To update annotations, use the cellular component term 'delta DNA polymerase complex ; GO:0043625'.
is_obsolete: true

[Term]
id: GO:0005660
name: delta-DNA polymerase cofactor complex
namespace: cellular_component
def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl, UniProtKB:P35249]
comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. To update annotations, use the cellular component terms 'DNA replication factor C complex ; GO:0005663' and 'PCNA complex ; GO:0043626'.
exact_synonym: "delta DNA polymerase cofactor complex" []
is_obsolete: true

[Term]
id: GO:0005662
name: DNA replication factor A complex
namespace: cellular_component
def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]
related_synonym: "single-stranded DNA-binding protein complex" []
related_synonym: "SSB" []
exact_synonym: "replication protein A" []
exact_synonym: "RPA" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! replisome (sensu Eukaryota)

[Term]
id: GO:0005663
name: DNA replication factor C complex
namespace: cellular_component
def: "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]
subset: gosubset_prok
exact_synonym: "activator 1 complex" []
exact_synonym: "RFC complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0005664
name: nuclear origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]
exact_synonym: "eukaryotic ORC" []
exact_synonym: "nuclear ORC" []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0005665
name: DNA-directed RNA polymerase II, core complex
namespace: cellular_component
def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc]
related_synonym: "DNA-directed RNA polymerase II activity" []
is_a: GO:0030880 ! RNA polymerase complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005666
name: DNA-directed RNA polymerase III complex
namespace: cellular_component
def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc]
related_synonym: "DNA-directed RNA polymerase III activity" []
is_a: GO:0030880 ! RNA polymerase complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005667
name: transcription factor complex
namespace: cellular_component
def: "Any complex, distinct from RNA polymerase, including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences, and regulating transcription." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005668
name: selectivity factor SL1 complex
namespace: cellular_component
def: "A RNA polymerase I-specific protein complex which in humans has two subunits, tata-binding protein (TBP) and TBP-associated factor 1 (TAF1)." [GOC:jl, PMID:9857193]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0005669
name: transcription factor TFIID complex
namespace: cellular_component
def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
related_synonym: "transcription-activating factor, 30kD" []
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005670
name: transcription-activating factor, 30kD
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'transcription factor TFIID complex ; GO:0005669'.
is_obsolete: true

[Term]
id: GO:0005671
name: Ada2/Gcn5/Ada3 transcription activator complex
namespace: cellular_component
def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0005672
name: transcription factor TFIIA complex
namespace: cellular_component
def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, UniProtKB:P52655]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005673
name: transcription factor TFIIE complex
namespace: cellular_component
def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, UniProtKB:P29083]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005674
name: transcription factor TFIIF complex
namespace: cellular_component
def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, UniProtKB:P13984]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005675
name: transcription factor TFIIH complex
namespace: cellular_component
def: "A transcription factor which in humans consists of a complex of six protein subunits. Involved in transcription by RNA polymerase II and in nucleotide excision repair." [GOC:jl, UniProtKB:Q13889]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005676
name: condensin complex
namespace: cellular_component
alt_id: GO:0008620
def: "OBSOLETE. A five-subunit protein complex that plays a central role in mitotic chromosome condensation. The Xenopus condensin complex is composed of two subcomplexes, an 8S core subcomplex (8SC)1 consisting of two structural maintenance of chromosomes (SMC) subunits (XCAP-C and -E) and an 11S regulatory subcomplex (11SR) containing three non-SMC subunits (XCAP-D2, -G, and -H)." [GOC:jl, PMID:11136719]
comment: This term was made obsolete because the definition is too specific; other organisms have condensin complexes. To update annotations, use the cellular component term 'condensin complex ; GO:0000796'.
narrow_synonym: "13S condensin" []
is_obsolete: true

[Term]
id: GO:0005677
name: chromatin silencing complex
namespace: cellular_component
def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0005678
name: chromatin assembly complex
namespace: cellular_component
def: "Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0005680
name: anaphase-promoting complex
namespace: cellular_component
def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, PMID:10465783, PMID:10611969]
exact_synonym: "anaphase promoting complex" []
exact_synonym: "APC" []
exact_synonym: "cyclosome" []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0005681
name: spliceosome complex
namespace: cellular_component
def: "A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron." [ISBN:0198547684]
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005682
name: snRNP U5
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U5; a component of both the major and minor spliceosome complexes." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005684 ! major (U2-dependent) spliceosome
relationship: part_of GO:0005689 ! minor (U12-dependent) spliceosome complex

[Term]
id: GO:0005683
name: snRNP U7
namespace: cellular_component
def: "A ribonucleoprotein complex, that includes the U7 snRNA, required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005684
name: major (U2-dependent) spliceosome
namespace: cellular_component
def: "The major (U2-dependent) spliceosome is composed of five snRNP complexes (U1, U2, U4, U5, and U6) as well as many non-snRNP proteins. It acts through many RNA-RNA, RNA-protein, and protein-protein interactions to precisely excise each intron and join the flanking exons." [PMID:11343900]
exact_synonym: "GT-AG spliceosome" []
exact_synonym: "major spliceosome" []
is_a: GO:0005681 ! spliceosome complex

[Term]
id: GO:0005685
name: snRNP U1
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U1; a component of the major spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005684 ! major (U2-dependent) spliceosome

[Term]
id: GO:0005686
name: snRNP U2
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U2; a component of the major spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005684 ! major (U2-dependent) spliceosome

[Term]
id: GO:0005687
name: snRNP U4
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U4; a component of the major spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005684 ! major (U2-dependent) spliceosome

[Term]
id: GO:0005688
name: snRNP U6
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U6; a component of the major spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005684 ! major (U2-dependent) spliceosome

[Term]
id: GO:0005689
name: minor (U12-dependent) spliceosome complex
namespace: cellular_component
def: "The minor (U12-dependent) spliceosome is composed of the snRNPs, U11, U12, U4atac, U6atac, and U5 (which is also a component of the major spliceosome). This minor form of the spliceosome is responsible for the splicing of the majority of introns with atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [PMID:11574683, PMID:11971955]
exact_synonym: "AT-AC spliceosome" []
exact_synonym: "minor spliceosome" []
is_a: GO:0005681 ! spliceosome complex

[Term]
id: GO:0005690
name: snRNP U4atac
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U4atac; a component of the minor spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005689 ! minor (U12-dependent) spliceosome complex

[Term]
id: GO:0005691
name: snRNP U6atac
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U6atac; a component of the minor spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005689 ! minor (U12-dependent) spliceosome complex

[Term]
id: GO:0005692
name: snRNP U11
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U11; a component of the minor spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005689 ! minor (U12-dependent) spliceosome complex

[Term]
id: GO:0005693
name: snRNP U12
namespace: cellular_component
def: "Ribonucleoprotein complex containing small nuclear RNA U12; a component of the minor spliceosome complex." [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
relationship: part_of GO:0005689 ! minor (U12-dependent) spliceosome complex

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_goa
subset: goslim_yeast
subset: gosubset_prok
related_synonym: "chromatid" []
narrow_synonym: "interphase chromosome" []
narrow_synonym: "prophase chromosome" []
is_a: GO:0043232 ! intracellular non-membrane-bound organelle

[Term]
id: GO:0005695
name: chromatid
namespace: cellular_component
def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732]
comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. To update annotations, consider the cellular component term 'chromosome ; GO:0005694' and the cellular component term 'condensed chromosome ; GO:0000793' and the cellular component term 'condensed nuclear chromosome ; GO:0000794'.
is_obsolete: true

[Term]
id: GO:0005696
name: telomere
namespace: cellular_component
def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732, PMID:11352055]
comment: This term was made obsolete because the definition was too sequence oriented and too restrictive. To update annotations, consider the cellular component term 'chromosome, telomeric region ; GO:0000781' and its children and the cellular component term 'telomere cap complex ; GO:0000782' and its children.
is_obsolete: true

[Term]
id: GO:0005697
name: telomerase holoenzyme complex
namespace: cellular_component
def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619]
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005698
name: centromere
namespace: cellular_component
def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732]
comment: This term was made obsolete because it is genetically defined region and not a specific subcellular localization. To update annotations, consider the cellular component term 'chromosome, pericentric region ; GO:0000775' and its children.
is_obsolete: true

[Term]
id: GO:0005699
name: kinetochore
namespace: cellular_component
def: "OBSOLETE. A specialized assembly of proteins that bind to the centromere and also attach to microtubules growing out from centrosomes during mitosis. 'They are involved in the separation of chromosomes into the daughter cells. They are composed of centromere-binding proteins." [ISBN:0198506732]
comment: This term was made obsolete because its definition was too specific. Kinetochores are also involved in meiosis. To update annotations, consider the cellular component term 'kinetochore ; GO:0000776' and its children.
is_obsolete: true

[Term]
id: GO:0005700
name: polytene chromosome
namespace: cellular_component
def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0005701
name: polytene chromosome chromocenter
namespace: cellular_component
def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
exact_synonym: "polytene chromosome chromocentre" []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005702
name: polytene chromosome weak point
namespace: cellular_component
def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012]
broad_synonym: "constriction" []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005703
name: polytene chromosome puff
namespace: cellular_component
def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005704
name: polytene chromosome band
namespace: cellular_component
def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005705
name: polytene chromosome interband
namespace: cellular_component
def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005706
name: polytene chromosome ectopic fiber
namespace: cellular_component
def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012]
exact_synonym: "polytene chromosome ectopic fibre" []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005707
name: interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider the cellular component term 'chromosome ; GO:0005694'.
is_obsolete: true

[Term]
id: GO:0005708
name: mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process. To update annotations, consider the cellular component term 'condensed chromosome ; GO:0000793' and the cellular component term 'condensed nuclear chromosome ; GO:0000794'.
is_obsolete: true

[Term]
id: GO:0005709
name: prophase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider the cellular component term 'chromosome ; GO:0005694'.
is_obsolete: true

[Term]
id: GO:0005710
name: metaphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider the cellular component term 'condensed chromosome ; GO:0000793' and the cellular component term 'condensed nuclear chromosome ; GO:0000794'.
is_obsolete: true

[Term]
id: GO:0005711
name: meiotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process. To update annotations, consider the cellular component term 'condensed nuclear chromosome ; GO:0000794'.
is_obsolete: true

[Term]
id: GO:0005712
name: chiasma
namespace: cellular_component
def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005713
name: recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005714
name: early recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005715
name: late recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005716
name: synaptonemal complex
namespace: cellular_component
def: "OBSOLETE. A structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]
comment: This term was made obsolete because the definition is not true for every organism. To update annotations, use the cellular component term 'synaptonemal complex ; GO:0000795'.
is_obsolete: true

[Term]
id: GO:0005717
name: chromatin
namespace: cellular_component
def: "OBSOLETE. The network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. It stains strongly with basic dyes. Some parts of the chromosomes are highly dispersed (called euchromatin) and other parts are highly condensed (called heterochromatin). Chromatin is made up of repeating units, each unit consisting of some 200 DNA base pairs and two each of histones H2A, H2B, H3, and H4; most of the DNA is wound around the outside of a core of histories to form nucleosomes. The remainder of the DNA, linker DNA, joins adjacent nucleosomes, thereby contributing flexibility to the chromatin fiber, a flexibly jointed chain of nucleosomes." [ISBN:0198506732]
comment: This term was made obsolete because the definition is too specific. To update annotations, consider the cellular component term 'chromatin ; GO:0000785' and its children.
is_obsolete: true

[Term]
id: GO:0005718
name: nucleosome
namespace: cellular_component
def: "OBSOLETE. A particle that forms the primary packing unit of DNA in chromatin. Each consists of a segment of duplex DNA, 160-240 base pairs long, with associated histone proteins; about 146 base pairs of the DNA comprise a core particle and the remainder form the linker DNA. The core particle is a disk-like structure, 11 nm in diameter and 5.7 nm thick, consisting of two molecules each of histories H2A, H2B, H3, and H4 with approximately two superhelical turns of double-stranded DNA wound round it. In many species, an average of one molecule of histone H1 (or a variant) is on the exterior of each core particle and appears to mediate the packing together of adjacent nucleosomes in condensed chromatin." [GOC:krc, ISBN:0198547684]
comment: This term was made obsolete because its definition is too specific; in addition to these common histones mentioned in the definition, there are histone variants. To update annotations, consider the cellular component term 'nucleosome ; GO:0000786' and its children.
is_obsolete: true

[Term]
id: GO:0005719
name: nuclear euchromatin
namespace: cellular_component
def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0000791 ! euchromatin

[Term]
id: GO:0005720
name: nuclear heterochromatin
namespace: cellular_component
def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0005721
name: centric heterochromatin
namespace: cellular_component
def: "Chromatin located near the centromere of a chromosome." [PMID:12019236]
exact_synonym: "centromeric heterochromatin" []
is_a: GO:0000792 ! heterochromatin
relationship: part_of GO:0000775 ! chromosome, pericentric region

[Term]
id: GO:0005722
name: beta-heterochromatin
namespace: cellular_component
def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678]
is_a: GO:0005721 ! centric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005723
name: alpha-heterochromatin
namespace: cellular_component
def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678]
is_a: GO:0005721 ! centric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005724
name: nuclear telomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai]
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:0031933 ! telomeric heterochromatin
relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region

[Term]
id: GO:0005725
name: intercalary heterochromatin
namespace: cellular_component
def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]
is_a: GO:0005720 ! nuclear heterochromatin

[Term]
id: GO:0005726
name: perichromatin fibrils
namespace: cellular_component
def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0005727
name: extrachromosomal circular DNA
namespace: cellular_component
def: "Circular DNA structures that are not part of a chromosome." [GOC:ai]
subset: gosubset_prok
related_synonym: "plasmid binding" []
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0046821 ! extrachromosomal DNA

[Term]
id: GO:0005728
name: extrachromosomal rDNA circle
namespace: cellular_component
def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934]
exact_synonym: "extrachromosomal ribosomal DNA circle" []
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005729
name: 2-micrometer circle DNA
namespace: cellular_component
def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320]
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005731
name: nucleolus organizer complex
namespace: cellular_component
exact_synonym: "nucleolus organiser complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0005732
name: small nucleolar ribonucleoprotein complex
namespace: cellular_component
def: "A complex composed of RNA of the small nucleolar RNA (snoRNA) and protein, found in the nucleolus of a eukaryotic cell. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897]
exact_synonym: "small nucleolar ribonucleoprotein" []
exact_synonym: "snoRNP" []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0005733
name: small nucleolar RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
exact_synonym: "snoRNA" []
is_obsolete: true

[Term]
id: GO:0005734
name: box C + D snoRNP protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0005735
name: box H + ACA snoRNP protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0005736
name: DNA-directed RNA polymerase I complex
namespace: cellular_component
def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc]
related_synonym: "DNA-directed RNA polymerase I activity" []
is_a: GO:0030880 ! RNA polymerase complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
exact_synonym: "mitochondria" []
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
subset: goslim_yeast
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0005741
name: mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
related_synonym: "metaxin" []
is_a: GO:0031966 ! mitochondrial membrane
is_a: GO:0031968 ! organelle outer membrane

[Term]
id: GO:0005742
name: mitochondrial outer membrane translocase complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]
narrow_synonym: "GIP complex" []
narrow_synonym: "TOM complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0005743
name: mitochondrial inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0005744
name: mitochondrial inner membrane presequence translocase complex
namespace: cellular_component
def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
exact_synonym: "mitochondrial inner membrane pre-sequence translocase complex" []
exact_synonym: "mitochondrial inner membrane translocase complex" []
narrow_synonym: "Tim23 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005745
name: m-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [PMID:12417197]
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005746
name: mitochondrial electron transport chain
namespace: cellular_component
def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane." [ISBN:0198547684]
exact_synonym: "respiratory chain" []
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005747
name: respiratory chain complex I (sensu Eukaryota)
namespace: cellular_component
alt_id: GO:0005748
def: "A part of the respiratory chain, containing about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron; the iron undergoes oxidation-reduction between Fe(II) and Fe(III). Catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0198547684]
exact_synonym: "NADH dehydrogenase complex (ubiquinone) (sensu Eukaryota)" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045271 ! respiratory chain complex I
relationship: part_of GO:0005746 ! mitochondrial electron transport chain

[Term]
id: GO:0005749
name: respiratory chain complex II (sensu Eukaryota)
namespace: cellular_component
alt_id: GO:0008136
alt_id: GO:0009362
alt_id: GO:0019738
alt_id: GO:0030390
def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0198547684]
exact_synonym: "fumarate reductase complex (sensu Eukaryota)" []
exact_synonym: "succinate dehydrogenase complex (sensu Eukaryota)" []
exact_synonym: "succinate dehydrogenase complex (ubiquinone) (sensu Eukaryota)" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone)
is_a: GO:0045281 ! succinate dehydrogenase complex
is_a: GO:0045283 ! fumarate reductase complex
relationship: part_of GO:0005746 ! mitochondrial electron transport chain

[Term]
id: GO:0005750
name: respiratory chain complex III (sensu Eukaryota)
namespace: cellular_component
alt_id: GO:0015008
def: "A part of the respiratory chain, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0198547684]
exact_synonym: "ubiquinol-cytochrome c oxidoreductase complex (sensu Eukaryota)" []
exact_synonym: "ubiquinol-cytochrome-c reductase complex (sensu Eukaryota)" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045275 ! respiratory chain complex III
is_a: GO:0045285 ! ubiquinol-cytochrome-c reductase complex
relationship: part_of GO:0005746 ! mitochondrial electron transport chain

[Term]
id: GO:0005751
name: respiratory chain complex IV (sensu Eukaryota)
namespace: cellular_component
alt_id: GO:0005752
def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Found in eukaryotes. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0198547684]
exact_synonym: "cytochrome c oxidase complex (sensu Eukaryota)" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045277 ! respiratory chain complex IV
relationship: part_of GO:0005746 ! mitochondrial electron transport chain

[Term]
id: GO:0005753
name: proton-transporting ATP synthase complex (sensu Eukaryota)
namespace: cellular_component
alt_id: GO:0016470
def: "The complex that catalyzes the phosphorylation of ADP to ATP in mitochondria, during oxidative phosphorylation; it catalyzes the hydrolysis of ATP to ADP and orthophosphate. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah, ISBN:0198547684]
exact_synonym: "hydrogen-translocating F-type ATPase complex (sensu Eukaryota)" []
exact_synonym: "respiratory chain complex V (sensu Eukaryota)" []
broad_synonym: "hydrogen-transporting ATP synthase" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045255 ! hydrogen-translocating F-type ATPase complex
is_a: GO:0045259 ! proton-transporting ATP synthase complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005754
name: proton-transporting ATP synthase, catalytic core (sensu Eukaryota)
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [PMID:10838056]
exact_synonym: "hydrogen-transporting ATP synthase, catalytic core (sensu Eukaryota)" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core
relationship: part_of GO:0000275 ! proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota)

[Term]
id: GO:0005755
name: hydrogen-transporting ATP synthase, coupling factor CF(0)
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created. To update annotations, consider the cellular component term 'proton-transporting ATP synthase complex, coupling factor F(o) ; GO:0045263' and its children.
is_obsolete: true

[Term]
id: GO:0005756
name: proton-transporting ATP synthase, central stalk (sensu Eukaryota)
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated F0 proteins; rotates within the catalytic core during catalysis. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [PMID:10838056]
exact_synonym: "hydrogen-transporting ATP synthase, central stalk (sensu Eukaryota)" []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk
relationship: part_of GO:0000275 ! proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota)

[Term]
id: GO:0005757
name: mitochondrial permeability transition pore
namespace: cellular_component
exact_synonym: "mitochondrial PT pore" []
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0005758
name: mitochondrial intermembrane space
namespace: cellular_component
alt_id: GO:0031971
def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
related_synonym: "mitochondrial membrane lumen" []
exact_synonym: "mitochondrial envelope lumen" []
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0005759
name: mitochondrial matrix
namespace: cellular_component
def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty-acid oxidation." [GOC:as, ISBN:0198506732]
narrow_synonym: "mitochondrial stroma" []
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0031980 ! mitochondrial lumen

[Term]
id: GO:0005760
name: gamma DNA polymerase complex
namespace: cellular_component
def: "A heterodimer consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093]
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005761
name: mitochondrial ribosome
namespace: cellular_component
def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732]
is_a: GO:0000313 ! organellar ribosome
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005762
name: mitochondrial large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005763
name: mitochondrial small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005764
name: lysosome
namespace: cellular_component
def: "Any of a group of related cytoplasmic, membrane bound organelles that are found in most animal cells and that contain a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
related_synonym: "lysosomal cysteine-type endopeptidase" []
related_synonym: "lysosomal protein stabilization" []
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0005765
name: lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0005766
name: primary lysosome
namespace: cellular_component
def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005767
name: secondary lysosome
namespace: cellular_component
def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005768
name: endosome
namespace: cellular_component
def: "A membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
related_synonym: "endosomal oligosaccharide transporter" []
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005769
name: early endosome
namespace: cellular_component
def: "Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered." [GOC:rb]
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005770
name: late endosome
namespace: cellular_component
def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [PMID:11964142, PMID:2557062]
exact_synonym: "prevacuolar compartment" []
broad_synonym: "PVC" []
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005771
name: multivesicular body
namespace: cellular_component
def: "A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881]
exact_synonym: "multivesicular endosome" [PMID:12122203]
exact_synonym: "MVB" []
exact_synonym: "MVE" [PMID:12122203]
is_a: GO:0005770 ! late endosome

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
related_synonym: "vacuolar carboxypeptidase Y" []
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005774
name: vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044437 ! vacuolar part

[Term]
id: GO:0005775
name: vacuolar lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044437 ! vacuolar part

[Term]
id: GO:0005776
name: autophagic vacuole
namespace: cellular_component
def: "A double-membrane bound vesicle in which endogenous cellular material is sequestered; known as autophagosome in yeast." [ISBN:0198547684, PMID:11099404]
exact_synonym: "autophagosome" []
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0005777
name: peroxisome
namespace: cellular_component
alt_id: GO:0019818
def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
related_synonym: "peroxisomal fatty acyl transporter" []
related_synonym: "peroxisomal membrane transporter" []
related_synonym: "peroxisome receptor" []
broad_synonym: "peroxisome vesicle" []
is_a: GO:0042579 ! microbody

[Term]
id: GO:0005778
name: peroxisomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a peroxisome." [GOC:mah]
related_synonym: "peroxisome integral membrane receptor" []
is_a: GO:0031903 ! microbody membrane
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0005779
name: integral to peroxisomal membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031231 ! intrinsic to peroxisomal membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0005780
name: extrinsic to intraperoxisomal membrane
namespace: cellular_component
def: "Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region." [GOC:mah]
related_synonym: "intra-peroxisomal peripheral membrane" []
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044439 ! peroxisomal part
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0005781
name: peroxisome targeting signal receptor complex
namespace: cellular_component
is_a: GO:0043235 ! receptor complex
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0005782
name: peroxisomal matrix
namespace: cellular_component
def: "The material contained within the membrane of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:mah, ISBN:0815316194]
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
exact_synonym: "ER" []
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005784
name: translocon complex
namespace: cellular_component
def: "A translocation complex that constitutes the specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. Composed of a heterotetramer of alpha, beta, gamma and delta subunits (translocon-associated proteins or TRAPs). In yeast it is a heterotrimeric complex consisting of Sec61p, Sbh1p, and Sss1p. The Sec61 complex functions in cotranslational and posttranslational translocation events." [GOC:rb, ISBN:0198599471]
narrow_synonym: "sec61 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0005785
name: signal recognition particle receptor complex
namespace: cellular_component
def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732]
related_synonym: "docking protein complex" []
exact_synonym: "SR complex" []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0005786
name: signal recognition particle (sensu Eukaryota)
namespace: cellular_component
alt_id: GO:0005855
def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0198506732]
related_synonym: "signal-recognition-particle GTPase activity" []
exact_synonym: "signal sequence receptor complex" []
exact_synonym: "SRP" []
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0005787
name: signal peptidase complex
namespace: cellular_component
def: "A multi subunit protease complex located in the endoplasmic reticulum membrane that cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0005788
name: endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
exact_synonym: "cisternal lumen" []
exact_synonym: "ER lumen" []
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0005789
name: endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
exact_synonym: "ER membrane" []
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network

[Term]
id: GO:0005790
name: smooth endoplasmic reticulum
namespace: cellular_component
def: "The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732]
exact_synonym: "smooth ER" []
is_a: GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005791
name: rough endoplasmic reticulum
namespace: cellular_component
def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]
exact_synonym: "rough ER" []
is_a: GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005792
name: microsome
namespace: cellular_component
def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0042598 ! vesicular fraction

[Term]
id: GO:0005793
name: ER-Golgi intermediate compartment
namespace: cellular_component
def: "A body found in cells where the endoplasmic reticulum is located several micrometers from the Golgi complex, formed from COP II coated vesicles that fuse with each other shortly after their formation." [ISBN:0716731363]
exact_synonym: "endoplasmic reticulum-Golgi intermediate compartment" []
exact_synonym: "ERGIC" []
exact_synonym: "pre-Golgi intermediate compartment" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
exact_synonym: "Golgi" []
exact_synonym: "Golgi complex" []
narrow_synonym: "Golgi ribbon" []
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005795
name: Golgi stack
namespace: cellular_component
alt_id: GO:0016940
def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
exact_synonym: "Golgi cisternae" []
narrow_synonym: "dictyosome" []
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005796
name: Golgi lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of any cisterna of the Golgi apparatus." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005797
name: Golgi medial cisterna
namespace: cellular_component
def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0005798
name: Golgi-associated vesicle
namespace: cellular_component
def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
comment: Note that this definition includes vesicles that are transiently associated with the Golgi.
related_synonym: "Golgi vesicle" []
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005799
name: coatomer
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. To update annotations, consider the cellular component terms 'COPI vesicle coat ; GO:0030126' and 'COPI-coated vesicle ; GO:0030137'.
related_synonym: "COPI vesicle" []
is_obsolete: true

[Term]
id: GO:0005800
name: COPII vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider the cellular component term 'ER to Golgi transport vesicle ; GO:0030134'.
is_obsolete: true

[Term]
id: GO:0005801
name: Golgi cis face
namespace: cellular_component
def: "The convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732]
exact_synonym: "forming face" []
exact_synonym: "Golgi cis-face" []
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005802
name: Golgi trans face
namespace: cellular_component
def: "The concave side of the Golgi apparatus, from which secretory vesicles emerge." [ISBN:0198506732]
exact_synonym: "Golgi trans-face" []
broad_synonym: "maturing face" []
broad_synonym: "trans-Golgi network" []
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005803
name: secretory vesicle
namespace: cellular_component
def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684]
comment: This term was made obsolete because it was being used to describe two different components. To update annotations, consider the cellular component terms 'transport vesicle ; GO:0030133' and 'secretory granule ; GO:0030141'.
exact_synonym: "secretory granule" []
narrow_synonym: "transition vesicle" []
broad_synonym: "transport vesicle" []
is_obsolete: true

[Term]
id: GO:0005804
name: secretory vesicle membrane
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its parent was made obsolete. To update annotations, consider the cellular component terms 'transport vesicle membrane ; GO:0030658' and 'secretory granule membrane ; GO:0030667'.
is_obsolete: true

[Term]
id: GO:0005805
name: ER-Golgi transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider the cellular component term 'ER to Golgi transport vesicle ; GO:0030134'.
is_obsolete: true

[Term]
id: GO:0005806
name: Golgi-ER transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider the cellular component term 'Golgi to ER transport vesicle ; GO:0030142'.
is_obsolete: true

[Term]
id: GO:0005807
name: inter-Golgi transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider the cellular component term 'inter-Golgi transport vesicle ; GO:0030143'.
is_obsolete: true

[Term]
id: GO:0005808
name: Golgi-plasma membrane transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. To update annotations, consider the cellular component term 'transport vesicle ; GO:0030133'.
is_obsolete: true

[Term]
id: GO:0005809
name: Golgi-vacuole transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider the cellular component term 'transport vesicle ; GO:0030133' and its children.
is_obsolete: true

[Term]
id: GO:0005810
name: endocytotic transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, use the cellular component term 'endocytic vesicle ; GO:0030139'.
is_obsolete: true

[Term]
id: GO:0005811
name: lipid particle
namespace: cellular_component
def: "Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins." [GOC:mah]
comment: Note that this term does not refer to vesicle, but instead to structures in which lipids do not necessarily form bilayers.
subset: goslim_generic
exact_synonym: "lipid droplet" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005813
name: centrosome
namespace: cellular_component
def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005814
name: centriole
namespace: cellular_component
def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0005815
name: microtubule organizing center
namespace: cellular_component
def: "A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [ISBN:0815316194]
subset: goslim_generic
subset: goslim_yeast
exact_synonym: "microtubule organising centre" []
exact_synonym: "MTOC" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005816
name: spindle pole body
namespace: cellular_component
def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568]
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0005817
name: centrosomal mitotic factor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:clt]
comment: This term was made obsolete because it was not defined.
is_obsolete: true

[Term]
id: GO:0005818
name: aster
namespace: cellular_component
def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005819
name: spindle
namespace: cellular_component
def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005821
name: intermediate layer of spindle pole body
namespace: cellular_component
def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005822
name: inner plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005823
name: central plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005824
name: outer plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005825
name: half bridge of spindle pole body
namespace: cellular_component
def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005826
name: contractile ring
namespace: cellular_component
alt_id: GO:0030480
def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194]
related_synonym: "actomyosin ring" []
related_synonym: "constriction ring" []
exact_synonym: "CAR" []
exact_synonym: "contractile actomyosin ring" []
narrow_synonym: "actomyosin ring (sensu Fungi)" []
narrow_synonym: "contractile ring (sensu Fungi)" []
narrow_synonym: "cytokinetic ring (sensu Fungi)" []
is_a: GO:0032155 ! cell division site part
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005827
name: polar microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194]
exact_synonym: "pole-to-pole microtubule" []
is_a: GO:0005876 ! spindle microtubule
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0005828
name: kinetochore microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
exact_synonym: "pole-to-kinetochore microtubule" []
is_a: GO:0005876 ! spindle microtubule

[Term]
id: GO:0005829
name: cytosol
namespace: cellular_component
def: "That part of the cytoplasm that does not contain membranous or particulate subcellular components." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005830
name: cytosolic ribosome (sensu Eukaryota)
namespace: cellular_component
def: "A ribosome found in the cytosol; this term can also be used to refer to ribosomes associated with the endoplasmic reticulum in eukaryotic cells. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
narrow_synonym: "80S ribosome" []
is_a: GO:0005840 ! ribosome
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005831
name: steroid hormone aporeceptor complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005832
name: chaperonin-containing T-complex
namespace: cellular_component
def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]
exact_synonym: "CCT particle" []
exact_synonym: "TriC" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005833
name: hemoglobin complex
namespace: cellular_component
def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732]
exact_synonym: "haemoglobin complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005834
name: heterotrimeric G-protein complex
namespace: cellular_component
def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
comment: See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'.
subset: gosubset_prok
related_synonym: "heterotrimeric G-protein GTPase activity" []
exact_synonym: "heterotrimeric G-protein" []
narrow_synonym: "heterotrimeric G-protein GTPase, alpha-subunit" []
narrow_synonym: "heterotrimeric G-protein GTPase, beta-subunit" []
narrow_synonym: "heterotrimeric G-protein GTPase, gamma-subunit" []
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0005835
name: fatty acid synthase complex
namespace: cellular_component
def: "A multienzyme complex required to convert carbohydrates to fatty acids, specifically acetyl CoA to palmitate." [GOC:sgd_curators, ISBN:0716746840]
subset: gosubset_prok
related_synonym: "holo-[acyl-carrier-protein] synthase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005836
name: fatty-acyl-CoA synthase complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005837
name: 26S proteasome
namespace: cellular_component
def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin moiety. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804]
comment: This term was made obsolete because its definition was inaccurate. To update annotations, consider the cellular component terms 'proteasome core complex (sensu Bacteria) ; GO:0000503', 'proteasome regulatory particle (sensu Bacteria) ; GO:0000504', and 'proteasome complex (sensu Eukaryota) ; GO:0000502' and its children.
is_obsolete: true

[Term]
id: GO:0005838
name: proteasome regulatory particle (sensu Eukaryota)
namespace: cellular_component
def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:rb]
narrow_synonym: "19S regulatory particle" []
narrow_synonym: "PA700 proteasome activator" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0000502 ! proteasome complex (sensu Eukaryota)

[Term]
id: GO:0005839
name: proteasome core complex (sensu Eukaryota)
namespace: cellular_component
def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. This complex is involved in the proteolysis of substrates in an ATP dependent manner and consists of four ring-like structures, two outer and two inner, each containing seven subunits. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:rb, PMID:10806206]
exact_synonym: "macropain" []
narrow_synonym: "20S core complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0000502 ! proteasome complex (sensu Eukaryota)

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
narrow_synonym: "ribosomal RNA" []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005842
name: cytosolic large ribosomal subunit (sensu Eukaryota)
namespace: cellular_component
def: "The large subunit of a ribosome; has a sedimentation coefficient of 60S. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jic]
narrow_synonym: "60S ribosomal subunit" []
broad_synonym: "cytosolic large ribosomal subunit" []
is_a: GO:0015934 ! large ribosomal subunit
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0005830 ! cytosolic ribosome (sensu Eukaryota)

[Term]
id: GO:0005843
name: cytosolic small ribosomal subunit (sensu Eukaryota)
namespace: cellular_component
def: "The small subunit of a eukaryotic cytosolic ribosome; has a sedimentation coefficient of 40S. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
narrow_synonym: "40S ribosomal subunit" []
broad_synonym: "cytosolic small ribosomal subunit" []
is_a: GO:0015935 ! small ribosomal subunit
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0005830 ! cytosolic ribosome (sensu Eukaryota)
relationship: part_of GO:0016282 ! eukaryotic 43S preinitiation complex
relationship: part_of GO:0016283 ! eukaryotic 48S initiation complex

[Term]
id: GO:0005844
name: polysome
namespace: cellular_component
def: "Several ribosomes bound to one mRNA." [ISBN:0198506732]
exact_synonym: "polyribosome" []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0005845
name: mRNA cap complex
namespace: cellular_component
def: "Any complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jic]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005846
name: snRNA cap binding complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005847
name: mRNA cleavage and polyadenylation specificity factor complex
namespace: cellular_component
def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]
related_synonym: "CFII complex" []
related_synonym: "cleavage and polyadenylylation specificity factor activity" []
narrow_synonym: "CPF complex" []
narrow_synonym: "CPSF complex" []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005848
name: mRNA cleavage stimulating factor complex
namespace: cellular_component
def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856]
related_synonym: "cleavage stimulation factor activity" []
narrow_synonym: "CstF complex" []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005849
name: mRNA cleavage factor complex
namespace: cellular_component
def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005850
name: eukaryotic translation initiation factor 2 complex
namespace: cellular_component
def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940]
exact_synonym: "eIF-2" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0016282 ! eukaryotic 43S preinitiation complex

[Term]
id: GO:0005851
name: eukaryotic translation initiation factor 2B complex
namespace: cellular_component
def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
exact_synonym: "eIF-2B" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005852
name: eukaryotic translation initiation factor 3 complex
namespace: cellular_component
def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex." [PMID:15904532]
exact_synonym: "eIF-3" []
exact_synonym: "eIF3" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0016282 ! eukaryotic 43S preinitiation complex

[Term]
id: GO:0005853
name: eukaryotic translation elongation factor 1 complex
namespace: cellular_component
def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950, UniProtKB:P24534]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005854
name: nascent polypeptide-associated complex
namespace: cellular_component
def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149]
exact_synonym: "NAC" []
exact_synonym: "NACA" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements within the cytoplasm of eukaryotic cells that remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0043232 ! intracellular non-membrane-bound organelle

[Term]
id: GO:0005858
name: axonemal dynein complex
namespace: cellular_component
def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which in converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194]
narrow_synonym: "axonemal dynein heavy chain" []
narrow_synonym: "axonemal dynein intermediate chain" []
narrow_synonym: "axonemal dynein intermediate light chain" []
narrow_synonym: "axonemal dynein light chain" []
is_a: GO:0030286 ! dynein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0005859
name: muscle myosin complex
namespace: cellular_component
def: "A filament of myosin found in a muscle cell of any type." [GOC:mah]
is_a: GO:0016460 ! myosin II complex
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0005861
name: troponin complex
namespace: cellular_component
def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005862
name: muscle thin filament tropomyosin
namespace: cellular_component
def: "An isoform of tropomyosin found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005863
name: striated muscle thick filament
namespace: cellular_component
def: "Filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [ISBN:0815316194]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0005865
name: striated muscle thin filament
namespace: cellular_component
def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0015629 ! actin cytoskeleton
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0005868
name: cytoplasmic dynein complex
namespace: cellular_component
def: "Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311]
narrow_synonym: "cytoplasmic dynein heavy chain" []
narrow_synonym: "cytoplasmic dynein intermediate chain" []
narrow_synonym: "cytoplasmic dynein intermediate light chain" []
narrow_synonym: "cytoplasmic dynein light chain" []
is_a: GO:0030286 ! dynein complex

[Term]
id: GO:0005869
name: dynactin complex
namespace: cellular_component
def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]
is_a: GO:0005875 ! microtubule associated complex
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005870
name: actin capping protein of dynactin complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, UniProtKB:P14315]
is_a: GO:0008290 ! F-actin capping protein complex
relationship: part_of GO:0005869 ! dynactin complex

[Term]
id: GO:0005871
name: kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0005872
name: minus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005873
name: plus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005874
name: microtubule
namespace: cellular_component
def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005875
name: microtubule associated complex
namespace: cellular_component
def: "Any multimeric complex connected to a microtubule." [GOC:jl]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005876
name: spindle microtubule
namespace: cellular_component
def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005879
name: axonemal microtubule
namespace: cellular_component
def: "A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [ISBN:0815316194]
is_a: GO:0005874 ! microtubule
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0005880
name: nuclear microtubule
namespace: cellular_component
def: "Any microtubule in the nucleus of a cell." [GOC:mah]
is_a: GO:0005874 ! microtubule
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005881
name: cytoplasmic microtubule
namespace: cellular_component
def: "Any microtubule in the cytoplasm of a cell." [GOC:mah]
narrow_synonym: "non-spindle-associated astral microtubule" []
is_a: GO:0005874 ! microtubule

[Term]
id: GO:0005882
name: intermediate filament
namespace: cellular_component
def: "A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells." [ISBN:0198506732]
related_synonym: "intermediate filament associated protein" []
related_synonym: "type I intermediate filament associated protein" []
related_synonym: "type II intermediate filament associated protein" []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0045111 ! intermediate filament cytoskeleton

[Term]
id: GO:0005883
name: neurofilament
namespace: cellular_component
def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194]
exact_synonym: "type IV intermediate filament" []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0005884
name: actin filament
namespace: cellular_component
def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
broad_synonym: "microfilament" []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005885
name: Arp2/3 protein complex
namespace: cellular_component
def: "A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments." [GOC:jl, PMID:12479800]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
related_synonym: "plasma membrane cation-transporting ATPase" []
related_synonym: "plasma membrane copper transporter" []
related_synonym: "plasma membrane long-chain fatty acid transporter" []
exact_synonym: "cell membrane" []
exact_synonym: "cytoplasmic membrane" []
exact_synonym: "plasmalemma" []
narrow_synonym: "bacterial inner membrane" []
broad_synonym: "juxtamembrane" []
is_a: GO:0016020 ! membrane

[Term]
id: GO:0005887
name: integral to plasma membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
subset: gosubset_prok
related_synonym: "proteoglycan integral to plasma membrane" []
related_synonym: "transmembrane ephrin" []
is_a: GO:0016021 ! integral to membrane
is_a: GO:0031226 ! intrinsic to plasma membrane

[Term]
id: GO:0005888
name: proteoglycan integral to plasma membrane
namespace: cellular_component
def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. To update annotations, use the cellular component term 'integral to plasma membrane ; GO:0005887'.
is_obsolete: true

[Term]
id: GO:0005889
name: hydrogen:potassium-exchanging ATPase complex
namespace: cellular_component
exact_synonym: "hydrogen/potassium-exchanging ATPase complex" []
broad_synonym: "proton pump" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005890
name: sodium:potassium-exchanging ATPase complex
namespace: cellular_component
def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
exact_synonym: "sodium/potassium-exchanging ATPase complex" []
broad_synonym: "sodium pump" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005891
name: voltage-gated calcium channel complex
namespace: cellular_component
exact_synonym: "voltage gated calcium channel complex" []
exact_synonym: "voltage-dependent calcium channel complex" []
exact_synonym: "voltage-sensitive calcium channel complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005892
name: nicotinic acetylcholine-gated receptor-channel complex
namespace: cellular_component
broad_synonym: "nicotinic acetylcholine receptor" []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005893
name: interleukin-2 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005894
name: interleukin-3 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005895
name: interleukin-5 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005896
name: interleukin-6 receptor complex
namespace: cellular_component
def: "A hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005897
name: interleukin-9 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005898
name: interleukin-13 receptor complex
namespace: cellular_component
def: "A complex that binds interleukin-13; consists of two chains, interleukin-4 receptor alpha chain and interleukin-4 receptor alpha chain." [UniProtKB:P78552]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005899
name: insulin receptor complex
namespace: cellular_component
def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005900
name: oncostatin-M receptor complex
namespace: cellular_component
def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005901
name: caveola
namespace: cellular_component
def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the cell membrane formed during pinocytosis, that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544]
exact_synonym: "caveolae" []
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0005902
name: microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005903
name: brush border
namespace: cellular_component
def: "Dense covering of microvilli on the apical surface of epithelial cells in the intestine and kidney; the microvilli aid absorption by increasing the surface area of the cell." [ISBN:0815316194]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005904
name: plasma membrane lipid bilayer
namespace: cellular_component
def: "The phospholipid membrane surrounding a cell that separates the cell from its external environment, excluding intergral and associated proteins." [GOC:go_curators]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0005905
name: coated pit
namespace: cellular_component
def: "An invagination of the cell membrane of many eukaryotic cells, concerned in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane. During endocytosis it is converted into a coated vesicle. The coat is of clathrin." [ISBN:0198506732]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0005906
name: clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. To update annotations, use the cellular component term 'membrane coat adaptor complex ; GO:0030119'.
related_synonym: "adaptin" []
is_obsolete: true

[Term]
id: GO:0005907
name: HA1 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. To update annotations, consider the cellular component term 'AP-1 adaptor complex ; GO:0030121'.
related_synonym: "AP1" []
is_obsolete: true

[Term]
id: GO:0005908
name: HA2 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. To update annotations, consider the cellular component term 'AP-2 adaptor complex ; GO:0030122'.
related_synonym: "AP2" []
is_obsolete: true

[Term]
id: GO:0005909
name: coated vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was positioned incorrectly. To update annotations, use the cellular component term 'coated vesicle ; GO:0030135'.
is_obsolete: true

[Term]
id: GO:0005911
name: intercellular junction
namespace: cellular_component
def: "A specialized region of connection between two cells including but not limited to gap junctions, desmosomes, and tight junctions, but excluding direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb]
exact_synonym: "cell-cell junction" []
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0005912
name: adherens junction
namespace: cellular_component
def: "A cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [ISBN:0198506732]
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0005913
name: cell-cell adherens junction
namespace: cellular_component
def: "An adherens junction which connects two cells to each other." [GOC:hb]
is_a: GO:0005911 ! intercellular junction
is_a: GO:0005912 ! adherens junction

[Term]
id: GO:0005914
name: spot adherens junction
namespace: cellular_component
def: "A small junction assombled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298]
exact_synonym: "punctum adherens" []
broad_synonym: "dense plaque" []
is_a: GO:0005913 ! cell-cell adherens junction

[Term]
id: GO:0005915
name: zonula adherens
namespace: cellular_component
def: "Cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
exact_synonym: "belt desmosome" []
exact_synonym: "intermediate junction" []
is_a: GO:0005913 ! cell-cell adherens junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005916
name: fascia adherens
namespace: cellular_component
def: "A broad intercellular junction in the intercalated disk of cardiac muscle that anchors actin filaments." [http://cancerweb.ncl.ac.uk/cgi-bin/omd?fascia+adherens]
broad_synonym: "intercalated disc" []
is_a: GO:0005913 ! cell-cell adherens junction

[Term]
id: GO:0005917
name: nephrocyte junction
namespace: cellular_component
def: "A tissue-specific adherens junction found in kidney cells." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm]
is_a: GO:0005913 ! cell-cell adherens junction

[Term]
id: GO:0005918
name: septate junction
namespace: cellular_component
def: "Invertebrate-specific cell-cell junctions which form a band around the apical borders of epithelial cells and attach to actin filaments." [ISBN:0815316208]
related_synonym: "septate desmosome" []
is_a: GO:0005913 ! cell-cell adherens junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005919
name: pleated septate junction
namespace: cellular_component
def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
related_synonym: "pleated desmosome" []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005920
name: smooth septate junction
namespace: cellular_component
def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298]
exact_synonym: "zonula continua" []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005921
name: gap junction
namespace: cellular_component
def: "Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon." [ISBN:0198506732]
exact_synonym: "communicating junction" []
exact_synonym: "macula communicans" []
exact_synonym: "zonula communicans" []
is_a: GO:0005911 ! intercellular junction

[Term]
id: GO:0005922
name: connexon complex
namespace: cellular_component
def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005921 ! gap junction

[Term]
id: GO:0005923
name: tight junction
namespace: cellular_component
def: "A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia." [ISBN:0198506732]
exact_synonym: "zonula occludens" []
is_a: GO:0005911 ! intercellular junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005924
name: cell-substrate adherens junction
namespace: cellular_component
def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb]
is_a: GO:0005912 ! adherens junction
is_a: GO:0030055 ! cell-matrix junction

[Term]
id: GO:0005925
name: focal adhesion
namespace: cellular_component
alt_id: GO:0008357
def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that are points of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
exact_synonym: "focal contact" []
exact_synonym: "hemi-adherens junction" []
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005926
name: connecting hemi-adherens junction
namespace: cellular_component
def: "A hemiadherens junction (HAJ) that forms juctions such that HAJs in opposing cells are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm]
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005927
name: muscle tendon junction
namespace: cellular_component
def: "An adherens junctions formed between a muscle cell and a tendon cell; the muscle and tendon cytoplasmic faces are distinct." [PMID:12842007]
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005928
name: apical hemi-adherens junction
namespace: cellular_component
def: "An adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298]
exact_synonym: "apical dense plaque" []
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005929
name: cilium
namespace: cellular_component
def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kva, ISBN:0198547684]
subset: goslim_generic
is_a: GO:0042995 ! cell projection
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0005930
name: axoneme
namespace: cellular_component
def: "The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [ISBN:0198547684]
related_synonym: "axonemal motor activity" []
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0005931
name: nexin complex
namespace: cellular_component
def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [ISBN:0198506732]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0005932
name: basal body
namespace: cellular_component
def: "A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth." [GOC:clt]
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0044463 ! cell projection part

[Term]
id: GO:0005933
name: bud
namespace: cellular_component
def: "A daughter cell of an organism that reproduces by budding; formed by pinching off part of the parent cell." [GOC:mah]
subset: goslim_yeast
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005934
name: bud tip
namespace: cellular_component
def: "The end of a bud distal to the site of attachment to the mother cell." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! bud

[Term]
id: GO:0005935
name: bud neck
namespace: cellular_component
def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! bud

[Term]
id: GO:0005936
name: shmoo
namespace: cellular_component
def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc]
comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the cellular component terms 'mating projection ; GO:0005937' and 'mating projection base ; GO:0001400', or the Fungal Anatomy Ontology term 'shmoo ; FAO:0001023'.
exact_synonym: "mating projection" []
is_obsolete: true

[Term]
id: GO:0005937
name: mating projection
namespace: cellular_component
def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc]
narrow_synonym: "conjugation tube" []
narrow_synonym: "shmoo" []
narrow_synonym: "shmoo tip" []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_yeast
related_synonym: "cell periphery" []
related_synonym: "peripheral cytoplasm" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005940
name: septin ring
namespace: cellular_component
alt_id: GO:0030481
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244]
narrow_synonym: "septin ring (sensu Fungi)" []
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0005941
name: unlocalized protein complex
namespace: cellular_component
def: "Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma]
comment: See also the cellular component term 'cellular component unknown ; GO:0008372'.
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0005942
name: phosphoinositide 3-kinase complex
namespace: cellular_component
def: "A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K)." [GOC:bf]
exact_synonym: "1-phosphatidylinositol 3-kinase complex" []
exact_synonym: "PI3K complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005943
name: 1-phosphatidylinositol-4-phosphate kinase, class IA complex
namespace: cellular_component
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005944
name: 1-phosphatidylinositol-4-phosphate kinase, class IB complex
namespace: cellular_component
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005945
name: 6-phosphofructokinase complex
namespace: cellular_component
def: "A allosteric homotetrameric molecule with glycolytic activity." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005946
name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
namespace: cellular_component
def: "An enzyme complex that in yeast is composed of three or four polypeptides: TPS1, TPS2, TPS3 and TSL1. Catalyzes the formation of alpha,alpha-trehalose 6-phosphate and UDP from UDP-glucose and D-glucose 6-phosphate." [GOC:jl, SP:P38426]
comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'.
exact_synonym: "trehalose-6-phosphate synthase complex" []
exact_synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005947
name: alpha-ketoglutarate dehydrogenase complex (sensu Eukaryota)
namespace: cellular_component
def: "Complex that possesses alpha-ketoglutarate dehydrogenase activity. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
broad_synonym: "2-oxoglutarate dehydrogenase complex" []
is_a: GO:0030062 ! tricarboxylic acid cycle enzyme complex (sensu Eukaryota)
is_a: GO:0045240 ! alpha-ketoglutarate dehydrogenase complex

[Term]
id: GO:0005948
name: acetolactate synthase complex
namespace: cellular_component
def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, UniProt:P37252]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
subset: gosubset_prok
exact_synonym: "acetohydroxyacid synthase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005949
name: aminoadipate-semialdehyde dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31, UniProtKB:Q12572]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products.
is_obsolete: true

[Term]
id: GO:0005950
name: anthranilate synthase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, UniProtKB:P09785]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005951
name: carbamoyl-phosphate synthase complex
namespace: cellular_component
def: "An enzyme complex that exists in monomer, dimer, and higher oligomeric forms. Catalysis of the reaction: 2 ATP + L-glutamine + carbon dioxide (CO2) + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate." [PMID:2868386]
comment: Note that in eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005952
name: cAMP-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.1.37, ISBN:0198506732]
subset: gosubset_prok
related_synonym: "PKA" []
exact_synonym: "3',5' cAMP-dependent protein kinase complex" []
exact_synonym: "3',5'-cAMP-dependent protein kinase complex" []
exact_synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" []
exact_synonym: "cyclic AMP-dependent protein kinase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005953
name: CAAX-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874, UniProtKB:P53609]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005954
name: calcium- and calmodulin-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.1.123, UniProtKB:Q9UQM7]
related_synonym: "CaMKII" []
exact_synonym: "calcium/calmodulin-dependent protein kinase complex" []
exact_synonym: "CAMK2" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005955
name: calcineurin complex
namespace: cellular_component
def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951]
exact_synonym: "protein phosphatase type 2B complex" []
narrow_synonym: "calcium-dependent protein serine/threonine phosphatase complex" []
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005956
name: protein kinase CK2 complex
namespace: cellular_component
def: "Complex that possesses casein kinase activity, found in nearly every subcellular compartment. Protein kinase CK2 complexes are usually tetramers of two alpha and two beta subunits, and can phosphorylate many protein substrates in addition to casein." [EC:2.7.1.37, GOC:mah, PMID:10994779]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. One function possessed by this complex is represented by the molecular function term 'casein kinase II ; GO:0004682'.
exact_synonym: "casein kinase II complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005957
name: debranching enzyme
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. To update annotations, consider the cellular component term 'isoamylase complex ; GO:0043033'.
is_obsolete: true

[Term]
id: GO:0005958
name: DNA-dependent protein kinase complex
namespace: cellular_component
alt_id: GO:0005959
def: "A large protein complex which is involved in the repair of DNA double-strand breaks and V(D)J recombination events. In mammals, it consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer, Ku, the nuclear phosphoprotein XRCC4 and DNA ligase IV." [GOC:jl, PMID:10854421, PMID:12235392]
exact_synonym: "DNA-PK complex" []
narrow_synonym: "DNA-dependent protein kinase, DNA-end-binding complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005960
name: glycine cleavage complex
namespace: cellular_component
def: "A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase." [MetaCyc:GCVMULTI-CPLX]
subset: gosubset_prok
exact_synonym: "glycine cleavage system" []
exact_synonym: "glycine synthase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005961
name: glycine dehydrogenase complex (decarboxylating)
namespace: cellular_component
def: "A component, along with aminomethyltransferase, of the glycine cleavage system; it is found as a homodimer or as a tetramer with two alpha subunits and two beta subunits." [EC:1.4.4.2]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005960 ! glycine cleavage complex

[Term]
id: GO:0005962
name: isocitrate dehydrogenase complex (NAD+) (sensu Eukaryota)
namespace: cellular_component
def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'.
is_a: GO:0030062 ! tricarboxylic acid cycle enzyme complex (sensu Eukaryota)
is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)

[Term]
id: GO:0005963
name: magnesium-dependent protein serine/threonine phosphatase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005964
name: phosphorylase kinase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.1.38]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005965
name: protein farnesyltransferase complex
namespace: cellular_component
def: "A complex that possesses protein farnesyltransferase activity." [GOC:mah]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005966
name: photoreceptor cyclic-nucleotide phosphodiesterase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005967
name: pyruvate dehydrogenase complex (sensu Eukaryota)
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0471331309, ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
exact_synonym: "pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)" []
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045254 ! pyruvate dehydrogenase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005968
name: Rab-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl moiety from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217, UniProtKB:Q08602]
exact_synonym: "GGTase-II complex" []
exact_synonym: "Rab geranylgeranyltransferase complex" []
exact_synonym: "RAB-protein geranylgeranyltransferase complex" []
exact_synonym: "RabGGTase complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005969
name: serine-pyruvate aminotransferase, type 2B complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005970
name: serine-pyruvate aminotransferase, type 1 complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0005971
name: ribonucleoside-diphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin." [BRENDA:1.17.4.1]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005972
name: fibrinogen alpha chain
namespace: cellular_component
alt_id: GO:0008005
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component term 'fibrinogen complex ; GO:0005577'.
is_obsolete: true

[Term]
id: GO:0005973
name: fibrinogen beta chain
namespace: cellular_component
alt_id: GO:0008006
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component term 'fibrinogen complex ; GO:0005577'.
is_obsolete: true

[Term]
id: GO:0005974
name: fibrinogen gamma chain
namespace: cellular_component
alt_id: GO:0008007
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component term 'fibrinogen complex ; GO:0005577'.
is_obsolete: true

[Term]
id: GO:0008002
name: lamina lucida
namespace: cellular_component
def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008003
name: lamina densa
namespace: cellular_component
def: "The electron-dense layer of the basal lamina; lies just below the lamina lucida." [ISBN:0815316194]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008004
name: lamina reticularis
namespace: cellular_component
def: "A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008008
name: membrane attack complex protein beta2 chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'membrane attack complex ; GO:0005579'.
is_obsolete: true

[Term]
id: GO:0008021
name: synaptic vesicle
namespace: cellular_component
def: "Secretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0008023
name: transcription elongation factor complex
namespace: cellular_component
def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0008024
name: transcription elongation factor complex b
namespace: cellular_component
def: "A complex of cyclin T and a cyclin-dependent protein kinase, catalyst, that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme." [UniProtKB:O60563]
comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0008043
name: ferritin complex
namespace: cellular_component
def: "A iron-storing protein complex, which in humans has 24 subunits. There are two different ferritin subunits, the L (light) chain and H (heavy) chain." [GOC:jl, UniProtKB:P02792]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0008051
name: farnesyl-diphosphate farnesyl transferase complex
namespace: cellular_component
def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah]
comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer. To update annotations, consider the molecular function term 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310'.
is_obsolete: true

[Term]
id: GO:0008074
name: guanylate cyclase complex, soluble
namespace: cellular_component
def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]
comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'.
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0008076
name: voltage-gated potassium channel complex
namespace: cellular_component
subset: gosubset_prok
exact_synonym: "voltage gated potassium channel complex" []
exact_synonym: "voltage-dependent potassium channel complex" []
exact_synonym: "voltage-sensitive potassium channel complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008087
name: light-activated voltage-gated calcium channel complex
namespace: cellular_component
exact_synonym: "light-activated voltage gated calcium channel complex" []
exact_synonym: "light-activated voltage-dependent calcium channel complex" []
exact_synonym: "light-activated voltage-sensitive calcium channel complex" []
is_a: GO:0005891 ! voltage-gated calcium channel complex

[Term]
id: GO:0008091
name: spectrin
namespace: cellular_component
def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0008180
name: signalosome complex
namespace: cellular_component
def: "A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]
exact_synonym: "CSN" []
narrow_synonym: "COP9 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0008230
name: ecdysone receptor holocomplex
namespace: cellular_component
def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0008231
name: repressor ecdysone receptor holocomplex
namespace: cellular_component
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008232
name: activator ecdysone receptor holocomplex
namespace: cellular_component
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008245
name: lysosomal membrane hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created. To update annotations, consider the cellular component term 'lysosomal hydrogen-translocating V-type ATPase complex ; GO:0046611' and its children.
related_synonym: "V-ATPase" []
is_obsolete: true

[Term]
id: GO:0008247
name: 2-acetyl-1-alkylglycerophosphocholine esterase complex
namespace: cellular_component
def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206, UniProtKB:Q28017]
comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'.
subset: gosubset_prok
exact_synonym: "1-alkyl-2-acetylglycerophosphocholine esterase complex" []
exact_synonym: "platelet-activating factor acetylhydrolase complex" []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0008250
name: oligosaccharyl transferase complex
namespace: cellular_component
def: "A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast." [ISBN:0879695595]
exact_synonym: "OST complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0008274
name: gamma-tubulin ring complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075]
exact_synonym: "gammaTuRC" []
is_a: GO:0000930 ! gamma-tubulin complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0000242 ! pericentriolar material

[Term]
id: GO:0008275
name: gamma-tubulin small complex
namespace: cellular_component
def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075]
exact_synonym: "gammaTuSC" []
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0008278
name: cohesin complex
namespace: cellular_component
alt_id: GO:0008279
def: "A protein complex required for sister chromatid cohesion in eukaryotes." [PMID:9887095]
related_synonym: "SMC complex" []
narrow_synonym: "14S cohesin" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0008280
name: cohesin core heterodimer
namespace: cellular_component
def: "The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes." [GOC:jl]
narrow_synonym: "9S cohesin" []
narrow_synonym: "Smc1-Smc3 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0008278 ! cohesin complex

[Term]
id: GO:0008282
name: ATP-sensitive potassium channel complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008287
name: protein serine/threonine phosphatase complex
namespace: cellular_component
def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0008290
name: F-actin capping protein complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0008303
name: caspase complex
namespace: cellular_component
def: "A cytosolic endopeptidase with specificity for the hydrolysis of aspartyl bonds. Caspases are involved in apoptosis." [ISBN:0198506732]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0008304
name: eukaryotic translation initiation factor 4 complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created. To update annotations, use the cellular component term 'eukaryotic translation initiation factor 4F complex ; GO:0016281'.
exact_synonym: "eIF-4" []
is_obsolete: true

[Term]
id: GO:0008305
name: integrin complex
namespace: cellular_component
def: "Any member of a family of heterodimeric transmembrane receptors for cell-adhesion molecules. The alpha and beta subunits are noncovalently bonded." [ISBN:0198506732, ISBN:0721662544]
subset: gosubset_prok
related_synonym: "laminin receptor protein" []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008328
name: ionotropic glutamate receptor complex
namespace: cellular_component
def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the centre of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008352
name: katanin complex
namespace: cellular_component
def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'.
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0008370
name: obsolete cellular component
namespace: cellular_component
def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008385
name: IkappaB kinase complex
namespace: cellular_component
def: "A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role." [GOC:ma]
exact_synonym: "IKK complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0008537
name: proteasome activator complex
namespace: cellular_component
def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb]
narrow_synonym: "PA28" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0008540
name: proteasome regulatory particle, base subcomplex (sensu Eukaryota)
namespace: cellular_component
def: "Refers to the subunits of the regulatory particle that directly associates with the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005838 ! proteasome regulatory particle (sensu Eukaryota)

[Term]
id: GO:0008541
name: proteasome regulatory particle, lid subcomplex (sensu Eukaryota)
namespace: cellular_component
def: "Refers to the subunits of the regulatory particle that forms the peripheral lid, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005838 ! proteasome regulatory particle (sensu Eukaryota)

[Term]
id: GO:0008621
name: condensin core heterodimer
namespace: cellular_component
def: "OBSOLETE. The core heterodimer of a condensin complex; the Xenopus condensin core heterodimer is an 8S subcomplex (8SC)1 consisting of two structural maintenance of chromosomes (SMC) subunits (XCAP-C and -E)." [GOC:jl]
comment: This term was made obsolete because the definition is too specific; other organisms have condensins as well. To update annotations, use the cellular component term 'condensin core heterodimer ; GO:0000797'.
narrow_synonym: "8S condensin" []
is_obsolete: true

[Term]
id: GO:0008622
name: epsilon DNA polymerase complex
namespace: cellular_component
def: "A nuclear DNA polymerase with proofreading exonuclease activity. High processivity in the absence of PCNA. Also involved in nucleotide-excision repair and mismatch repair." [PMID:9745046]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000109 ! nucleotide-excision repair complex
relationship: part_of GO:0043601 ! replisome (sensu Eukaryota)

[Term]
id: GO:0008623
name: chromatin accessibility complex
namespace: cellular_component
alt_id: GO:0016588
def: "A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing." [GOC:bf, PMID:9252192]
exact_synonym: "CHRAC" []
narrow_synonym: "ISW2 complex" []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0009274
name: cell wall (sensu Bacteria)
namespace: cellular_component
def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan, a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids; also called murein. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
exact_synonym: "murein sacculus" []
narrow_synonym: "peptidoglycan" []
broad_synonym: "envelope (sensu Bacteria)" []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009275
name: cell wall (sensu Firmicutes)
namespace: cellular_component
def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (approximately 40 nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. As in but not restricted to the Gram-positive bacteria (Firmicutes, ncbi_taxonomy_id:1239)." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
exact_synonym: "cell wall (sensu Gram-positive bacteria)" []
exact_synonym: "murein sacculus" []
narrow_synonym: "peptidoglycan" []
is_a: GO:0009274 ! cell wall (sensu Bacteria)

[Term]
id: GO:0009276
name: cell wall (sensu Proteobacteria)
namespace: cellular_component
def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (approximately 2 nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. As in but not restricted to the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
exact_synonym: "cell wall (sensu Gram-negative bacteria)" []
exact_synonym: "cell wall inner membrane" []
exact_synonym: "murein sacculus" []
narrow_synonym: "peptidoglycan" []
is_a: GO:0009274 ! cell wall (sensu Bacteria)
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009277
name: cell wall (sensu Fungi)
namespace: cellular_component
def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis. Major components are glycoproteins and peptidoglycans including mannoproteins, glucans and sometimes chitin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [PMID:11283274, PMID:3319422]
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009278
name: murein sacculus
namespace: cellular_component
def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately. To update annotations, consider the cellular component term 'cell wall (sensu Proteobacteria) ; GO:0009276'.
broad_synonym: "capsule" []
is_obsolete: true

[Term]
id: GO:0009279
name: outer membrane (sensu Proteobacteria)
namespace: cellular_component
def: "A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [ISBN:0135712254]
subset: gosubset_prok
related_synonym: "outer membrane exporter porin" []
exact_synonym: "outer membrane (sensu Gram-negative bacteria)" []
is_a: GO:0019867 ! outer membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009280
name: cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately. To update annotations, consider the cellular component term 'cell wall (sensu Proteobacteria) ; GO:0009276'.
broad_synonym: "cytoplasmic membrane" []
is_obsolete: true

[Term]
id: GO:0009281
name: cytosolic ribosome (sensu Bacteria)
namespace: cellular_component
def: "The cytosolic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
narrow_synonym: "70S ribosome" []
is_a: GO:0005840 ! ribosome
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0009282
name: cytosolic large ribosomal subunit (sensu Bacteria)
namespace: cellular_component
alt_id: GO:0030498
def: "The large subunit of a ribosome; has a sedimentation coefficient of 50S. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
narrow_synonym: "50S ribosomal subunit" []
broad_synonym: "cytosolic large ribosomal subunit" []
broad_synonym: "prokaryotic large ribosomal subunit" []
is_a: GO:0015934 ! large ribosomal subunit
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0009281 ! cytosolic ribosome (sensu Bacteria)

[Term]
id: GO:0009283
name: cytosolic small ribosomal subunit (sensu Bacteria)
namespace: cellular_component
alt_id: GO:0030499
def: "The small subunit of a ribosome; has a sedimentation coefficient of 30S. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
broad_synonym: "30S ribosomal subunit" []
broad_synonym: "cytosolic small ribosomal subunit" []
broad_synonym: "prokaryotic small ribosomal subunit" []
is_a: GO:0015935 ! small ribosomal subunit
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0009281 ! cytosolic ribosome (sensu Bacteria)

[Term]
id: GO:0009288
name: flagellum (sensu Bacteria)
namespace: cellular_component
def: "A 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:ma, ISBN:0914826859]
subset: gosubset_prok
is_a: GO:0019861 ! flagellum

[Term]
id: GO:0009289
name: fimbrium
namespace: cellular_component
def: "A proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter." [ISBN:0598034692]
subset: gosubset_prok
exact_synonym: "fimbriae" []
broad_synonym: "fimbria" []
broad_synonym: "pilus" []
is_a: GO:0043232 ! intracellular non-membrane-bound organelle

[Term]
id: GO:0009295
name: nucleoid
namespace: cellular_component
def: "The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ma, ISBN:3540076689]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009316
name: 3-isopropylmalate dehydratase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, UniProtKB:Q8TW31]
comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'.
subset: gosubset_prok
exact_synonym: "isopropylmalate isomerase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0009317
name: acetyl-CoA carboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, UniProtKB:P24182]
subset: gosubset_prok
exact_synonym: "ACCase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009318
name: exodeoxyribonuclease VII complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6]
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009319
name: cytochrome o ubiquinol oxidase complex
namespace: cellular_component
def: "A bacterial heterooctameric enzyme composed of two A chains, two B chains, two C chains and two D chains. Possesses cytochrome o ubiquinol oxidase activity." [GOC:jl, UniProtKB:P0ABJ3]
comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016021 ! integral to membrane

[Term]
id: GO:0009320
name: phosphoribosylaminoimidazole carboxylase complex
namespace: cellular_component
def: "Complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah]
comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'.
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009321
name: alkyl hydroperoxide reductase complex
namespace: cellular_component
def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, UniProtKB:P0A0B5]
comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009322
name: trimethylamine-N-oxide reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009323
name: ribosomal-protein-alanine N-acetyltransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128]
is_a: GO:0031248 ! protein acetyltransferase complex

[Term]
id: GO:0009324
name: D-amino-acid dehydrogenase complex
namespace: cellular_component
def: "Complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah]
comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'.
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009325
name: nitrate reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4]
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009326
name: formate dehydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009327
name: NAD(P)+ transhydrogenase complex (AB-specific)
namespace: cellular_component
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009328
name: phenylalanine-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009329
name: acetate CoA-transferase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, UniProtKB:P08193]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex

[Term]
id: GO:0009330
name: DNA topoisomerase complex (ATP-hydrolyzing)
namespace: cellular_component
def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'.
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009331
name: glycerol-3-phosphate dehydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.99.5]
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009332
name: glutamate-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009333
name: cysteine synthase complex
namespace: cellular_component
def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009334
name: 3-phenylpropionate dioxygenase complex
namespace: cellular_component
def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, UniProtKB:P77650]
comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009335
name: holo-[acyl-carrier protein] synthase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term. To update annotations, consider the cellular component term 'fatty acid synthase complex ; GO:0005835'.
exact_synonym: "holo-ACP synthase complex" []
is_obsolete: true

[Term]
id: GO:0009336
name: sulfate adenylyltransferase complex (ATP)
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4]
exact_synonym: "sulphate adenylyltransferase complex (ATP)" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009337
name: sulfite reductase complex (NADPH)
namespace: cellular_component
def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyses the reduction of hydrogen sulfide to sulfide." [BRENDA:1.8.1.2, GOC:jl]
comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'.
subset: gosubset_prok
exact_synonym: "sulphite reductase complex (NADPH)" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009338
name: exodeoxyribonuclease V complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5]
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009339
name: glycolate oxidase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15]
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009340
name: DNA topoisomerase IV complex
namespace: cellular_component
def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, PARC and PARE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, UniProtKB:Q45066]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009341
name: beta-galactosidase complex
namespace: cellular_component
def: "A multimeric enzyme complex that in E. coli is an heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23, UniProtKB:P06864]
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009342
name: glutamate synthase complex (NADPH)
namespace: cellular_component
def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah]
subset: gosubset_prok
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0009343
name: biotin carboxylase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex

[Term]
id: GO:0009344
name: nitrite reductase complex [NAD(P)H]
namespace: cellular_component
def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah]
comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'.
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009345
name: glycine-tRNA ligase complex
namespace: cellular_component
def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, UniProtKB:Q10039, UniProtKB:Q8YVJ2]
subset: gosubset_prok
exact_synonym: "glycine-tRNA synthetase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009346
name: citrate lyase complex
namespace: cellular_component
def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009347
name: aspartate carbamoyltransferase complex
namespace: cellular_component
def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693]
comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009348
name: ornithine carbamoyltransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a carbamoyl to ornithine, forming citrulline." [EC:2.1.3.3]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009349
name: riboflavin synthase complex
namespace: cellular_component
def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009350
name: ethanolamine ammonia-lyase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009351
name: dihydrolipoamide S-acyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12]
comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide.
is_obsolete: true

[Term]
id: GO:0009352
name: dihydrolipoyl dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah]
comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself. To update annotations, consider the molecular function term 'dihydrolipoyl dehydrogenase activity ; GO:0004148' and the cellular component terms 'alpha-ketoglutarate dehydrogenase complex ; GO:0045240' and 'pyruvate dehydrogenase complex ; GO:0045254'.
exact_synonym: "dihydrolipoamide dehydrogenase complex" []
is_obsolete: true

[Term]
id: GO:0009353
name: oxoglutarate dehydrogenase complex (sensu Eukaryota)
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [UniProtKB:Q60597]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045252 ! oxoglutarate dehydrogenase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0009354
name: dihydrolipoamide S-succinyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61]
comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide. To update annotations, consider the cellular component term 'oxoglutarate dehydrogenase complex ; GO:0045252' and its children.
is_obsolete: true

[Term]
id: GO:0009355
name: DNA polymerase V complex
namespace: cellular_component
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009356
name: p-aminobenzoate synthetase complex
namespace: cellular_component
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009357
name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009358
name: polyphosphate kinase complex
namespace: cellular_component
def: "Complex that possesses polyphosphate kinase activity." [GOC:mah]
comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'.
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009359
name: Type II site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
exact_synonym: "Type II restriction enzyme complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009360
name: DNA polymerase III complex
namespace: cellular_component
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009361
name: succinate-CoA ligase complex (ADP-forming)
namespace: cellular_component
def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl]
is_a: GO:0042709 ! succinate-CoA ligase complex

[Term]
id: GO:0009365
name: protein histidine kinase complex
namespace: cellular_component
def: "A complex that possesses protein histidine kinase activity." [GOC:mah]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009366
name: enterobactin synthetase complex
namespace: cellular_component
def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [UniProtKB:P15048]
subset: gosubset_prok
exact_synonym: "enterochelin synthetase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009367
name: prepilin peptidase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0009368
name: endopeptidase Clp complex
namespace: cellular_component
def: "An enzymatically active or inactive multimeric complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits." [PMID:11352464]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009375
name: ferredoxin hydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.18.99.1]
subset: gosubset_prok
broad_synonym: "hydrogenase complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009376
name: HslUV protease complex
namespace: cellular_component
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009379
name: Holliday junction helicase complex
namespace: cellular_component
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009380
name: excinuclease ABC complex
namespace: cellular_component
subset: gosubset_prok
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009382
name: imidazoleglycerol-phosphate synthase complex
namespace: cellular_component
def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah]
comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'.
subset: gosubset_prok
exact_synonym: "imidazoleglycerol phosphate synthase complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009390
name: dimethyl sulfoxide reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188]
exact_synonym: "dimethyl sulphoxide reductase complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0009417
name: fimbrin
namespace: cellular_component
def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859]
comment: This term was made obsolete because it represents a class of gene products. To update annotations, use the cellular component term 'fimbrium ; GO:0009289'.
subset: gosubset_prok
is_obsolete: true

[Term]
id: GO:0009418
name: fimbrial shaft
namespace: cellular_component
def: "The long, slender, mid section of a fimbrium." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044443 ! fimbrial part

[Term]
id: GO:0009419
name: fimbrial tip
namespace: cellular_component
def: "The pointed extremity furthest from the cell of a fimbrium." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044443 ! fimbrial part

[Term]
id: GO:0009420
name: flagellar filament (sensu Bacteria)
namespace: cellular_component
def: "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)

[Term]
id: GO:0009421
name: flagellar filament cap (sensu Bacteria)
namespace: cellular_component
def: "The proteinaceous structure at the distal tip of the flagellar filament. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0009420 ! flagellar filament (sensu Bacteria)

[Term]
id: GO:0009422
name: flagellar hook-filament junction (sensu Bacteria)
namespace: cellular_component
def: "The region of the flagellum where the hook and filament meet. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah, PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)

[Term]
id: GO:0009424
name: flagellar hook (sensu Bacteria)
namespace: cellular_component
def: "The portion of the flagellum that connects the filament to the basal body. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)

[Term]
id: GO:0009425
name: flagellar basal body (sensu Bacteria)
namespace: cellular_component
def: "One of the three major substructures of the flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)

[Term]
id: GO:0009426
name: flagellar basal body, distal rod (sensu Bacteria)
namespace: cellular_component
def: "The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0030694 ! flagellar basal body, rod (sensu Bacteria)

[Term]
id: GO:0009427
name: flagellar basal body, distal rod, L ring (sensu Bacteria)
namespace: cellular_component
def: "One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0009426 ! flagellar basal body, distal rod (sensu Bacteria)

[Term]
id: GO:0009428
name: flagellar basal body, distal rod, P ring (sensu Bacteria)
namespace: cellular_component
def: "One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0009426 ! flagellar basal body, distal rod (sensu Bacteria)

[Term]
id: GO:0009429
name: flagellar basal body, proximal rod (sensu Bacteria)
namespace: cellular_component
def: "The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0030694 ! flagellar basal body, rod (sensu Bacteria)

[Term]
id: GO:0009431
name: flagellar basal body, MS ring (sensu Bacteria)
namespace: cellular_component
alt_id: GO:0009430
def: "One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
exact_synonym: "flagellar basal body, mounting plate (sensu Bacteria)" []
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0009425 ! flagellar basal body (sensu Bacteria)

[Term]
id: GO:0009433
name: flagellar basal body, C ring (sensu Bacteria)
namespace: cellular_component
def: "Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0009425 ! flagellar basal body (sensu Bacteria)

[Term]
id: GO:0009434
name: flagellum (sensu Eukaryota)
namespace: cellular_component
def: "A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0815316194]
comment: See also the cellular component term 'cilium ; GO:0005929'.
is_a: GO:0019861 ! flagellum
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0009501
name: amyloplast
namespace: cellular_component
def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009502
name: photosynthetic electron transport chain
namespace: cellular_component
def: "A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [ISBN:014051403]
subset: gosubset_prok
is_a: GO:0044436 ! thylakoid part

[Term]
id: GO:0009503
name: light-harvesting complex (sensu Viridiplantae)
namespace: cellular_component
def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [ISBN:0198547684]
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009535 ! thylakoid membrane (sensu Viridiplantae)

[Term]
id: GO:0009504
name: cell plate
namespace: cellular_component
def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009505
name: cell wall (sensu Magnoliophyta)
namespace: cellular_component
def: "A more or less rigid membrane enclosing the protoplast of a cell and composed of cellulose and other organic and inorganic substances. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [ISBN:0471245208]
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009506
name: plasmodesma
namespace: cellular_component
def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732]
exact_synonym: "plasmodesmata" []
is_a: GO:0005911 ! intercellular junction

[Term]
id: GO:0009507
name: chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009508
name: plastid chromosome
namespace: cellular_component
def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999]
is_a: GO:0005694 ! chromosome
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0042646 ! plastid nucleoid

[Term]
id: GO:0009509
name: chromoplast
namespace: cellular_component
def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009510
name: plasmodesmatal desmotubule
namespace: cellular_component
def: "A narrow cylindrical tubule that runs through the center of a plasmodesma connecting two cells. The latter appears to be continuous with elements of the endoplasmic reticulum membrane of the interconnected cells." [ISBN:0198506732]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009511
name: plasmodesmatal endoplasmic reticulum
namespace: cellular_component
def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai]
exact_synonym: "plasmodesmatal ER" []
is_a: GO:0005783 ! endoplasmic reticulum
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009510 ! plasmodesmatal desmotubule

[Term]
id: GO:0009512
name: cytochrome b6f complex
namespace: cellular_component
def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen." [ISBN:0943883999]
subset: gosubset_prok
exact_synonym: "cyt b(6)f complex" []
exact_synonym: "cyt b6-f complex" []
exact_synonym: "cyt b6/f complex" []
exact_synonym: "cyt b6f complex" []
exact_synonym: "cytochrome b(6)f complex" []
exact_synonym: "cytochrome b6-f complex" []
exact_synonym: "cytochrome b6/f complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009502 ! photosynthetic electron transport chain

[Term]
id: GO:0009513
name: etioplast
namespace: cellular_component
def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009514
name: glyoxysome
namespace: cellular_component
def: "A microbody that contains the enzymes of the glyoxylate pathway." [ISBN:0140514031]
is_a: GO:0042579 ! microbody

[Term]
id: GO:0009515
name: granal stacked thylakoid
namespace: cellular_component
def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr]
exact_synonym: "chloroplast stacked thylakoid" []
is_a: GO:0009534 ! thylakoid (sensu Viridiplantae)
relationship: part_of GO:0009542 ! granum

[Term]
id: GO:0009516
name: leucoplast
namespace: cellular_component
def: "Colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009517
name: PSII associated light-harvesting complex II
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089]
exact_synonym: "LHCII" []
is_a: GO:0009503 ! light-harvesting complex (sensu Viridiplantae)

[Term]
id: GO:0009518
name: PSI associated light-harvesting complex I
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem I." [GOC:lr]
exact_synonym: "LHCI" []
is_a: GO:0009503 ! light-harvesting complex (sensu Viridiplantae)

[Term]
id: GO:0009519
name: middle lamella
namespace: cellular_component
def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0009521
name: photosystem
namespace: cellular_component
def: "One of the photochemical systems containing photosynthetic and accessory pigments and electron carriers that operate in sequence to perform the two light reactions of photosynthesis." [ISBN:0140514031]
subset: gosubset_prok
is_a: GO:0044436 ! thylakoid part

[Term]
id: GO:0009522
name: photosystem I
namespace: cellular_component
def: "Photosystem that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin." [ISBN:0943088399]
subset: gosubset_prok
is_a: GO:0009521 ! photosystem
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0009523
name: photosystem II
namespace: cellular_component
def: "An integral membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [ISBN:0943088399]
subset: gosubset_prok
is_a: GO:0009521 ! photosystem
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0009524
name: phragmoplast
namespace: cellular_component
def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009525
name: phragmosome
namespace: cellular_component
def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009526
name: plastid envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy]
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0009527
name: plastid outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr]
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009528
name: plastid inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr]
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009529
name: plastid intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr]
exact_synonym: "plastid envelope lumen" []
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0009530
name: primary cell wall
namespace: cellular_component
def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0009505 ! cell wall (sensu Magnoliophyta)
is_a: GO:0048196 ! extracellular matrix (sensu Magnoliophyta)

[Term]
id: GO:0009531
name: secondary cell wall
namespace: cellular_component
def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0009505 ! cell wall (sensu Magnoliophyta)
is_a: GO:0048196 ! extracellular matrix (sensu Magnoliophyta)

[Term]
id: GO:0009532
name: plastid stroma
namespace: cellular_component
def: "The proteinaceous ground substance of plastids." [ISBN:047142520]
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0009533
name: chloroplast stromal thylakoid
namespace: cellular_component
def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999]
is_a: GO:0009534 ! thylakoid (sensu Viridiplantae)
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009534
name: thylakoid (sensu Viridiplantae)
namespace: cellular_component
def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [ISBN:0943883999]
exact_synonym: "chloroplast thylakoid" []
is_a: GO:0031976 ! plastid thylakoid
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009535
name: thylakoid membrane (sensu Viridiplantae)
namespace: cellular_component
def: "The pigmented membrane of a thylakoid. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [GOC:lr]
exact_synonym: "chloroplast thylakoid membrane" []
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009534 ! thylakoid (sensu Viridiplantae)

[Term]
id: GO:0009536
name: plastid
namespace: cellular_component
def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009537
name: proplastid
namespace: cellular_component
def: "The precursor of other plastids." [ISBN:0943883999]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009538
name: photosystem I reaction center
namespace: cellular_component
def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [ISBN:0943088399, UniProtKB:kd]
subset: gosubset_prok
exact_synonym: "photosystem I reaction centre" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009539
name: photosystem II reaction center
namespace: cellular_component
def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [ISBN:0943088399, UniProtKB:kd]
subset: gosubset_prok
exact_synonym: "photosystem II reaction centre" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009541
name: etioplast prolamellar body
namespace: cellular_component
def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031]
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009542
name: granum
namespace: cellular_component
def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403]
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009543
name: thylakoid lumen (sensu Viridiplantae)
namespace: cellular_component
def: "A cavity enclosed within the thylakoid membrane. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [ISBN:006501037]
is_a: GO:0031978 ! plastid thylakoid lumen
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009534 ! thylakoid (sensu Viridiplantae)

[Term]
id: GO:0009544
name: chloroplast ATP synthase complex
namespace: cellular_component
def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768]
is_a: GO:0043234 ! protein complex
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009535 ! thylakoid membrane (sensu Viridiplantae)

[Term]
id: GO:0009545
name: elaioplast
namespace: cellular_component
def: "A leucoplast in which oil is stored." [ISBN:0140514031]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009546
name: plasmodesmatal cytoplasmic sleeve
namespace: cellular_component
exact_synonym: "plasmodesmatal cytoplasmic annulus" []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009547
name: plastid ribosome
namespace: cellular_component
def: "A ribosome contained within a plastid." [GOC:tair_curators]
is_a: GO:0000313 ! organellar ribosome
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0009548
name: plasmodesmatal plasma membrane
namespace: cellular_component
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009549
name: cellulose microfibril
namespace: cellular_component
def: "Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the protoplast." [GOC:jic, http://cancerweb.ncl.ac.uk, ISBN:0943088399]
is_a: GO:0001527 ! microfibril
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0009550
name: primary plasmodesma
namespace: cellular_component
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009551
name: secondary plasmodesma
namespace: cellular_component
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009568
name: amyloplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
exact_synonym: "amyloplast starch granule" []
is_a: GO:0043036 ! starch grain
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0009569
name: chloroplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732]
exact_synonym: "chloroplast starch granule" []
is_a: GO:0043036 ! starch grain
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009570
name: chloroplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684]
is_a: GO:0009532 ! plastid stroma
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009571
name: proplastid stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a proplastid." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009537 ! proplastid

[Term]
id: GO:0009572
name: desmotubule central rod
namespace: cellular_component
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009510 ! plasmodesmatal desmotubule

[Term]
id: GO:0009573
name: ribulose bisphosphate carboxylase complex (sensu Magnoliophyta)
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:mlg]
exact_synonym: "RubisCO complex (sensu Magnoliophyta)" []
is_a: GO:0044434 ! chloroplast part
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009574
name: preprophase band
namespace: cellular_component
def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009575
name: chromoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009509 ! chromoplast

[Term]
id: GO:0009576
name: leucoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009516 ! leucoplast

[Term]
id: GO:0009577
name: elaioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009545 ! elaioplast

[Term]
id: GO:0009578
name: etioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009579
name: thylakoid
namespace: cellular_component
def: "A sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms. In prokaryotes the thylakoids are of various shapes and are attached to the plasma membrane. In eukaryotes they are flattened, membrane-bound disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
related_synonym: "photosynthetic membrane" []
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0009580
name: thylakoid (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific children exist. To update annotations, consider the cellular component terms 'thylakoid (sensu Cyanobacteria) ; GO:0030075' and 'chromatophore ; GO:0042716' and its children.
is_obsolete: true

[Term]
id: GO:0009654
name: oxygen evolving complex
namespace: cellular_component
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009655
name: PSII associated light-harvesting complex II, core complex
namespace: cellular_component
def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr]
narrow_synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" []
narrow_synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" []
narrow_synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009656
name: PSII associated light-harvesting complex II, peripheral complex
namespace: cellular_component
def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009705
name: vacuolar membrane (sensu Magnoliophyta)
namespace: cellular_component
def: "The lipid bilayer enclosing the vacuole; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [ISBN:0471245208]
exact_synonym: "tonoplast" []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000325 ! vacuole (sensu Magnoliophyta)

[Term]
id: GO:0009706
name: chloroplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb]
exact_synonym: "chloroplast inner envelope" []
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009707
name: chloroplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb]
exact_synonym: "chloroplast outer envelope" []
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009782
name: photosystem I antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009783
name: photosystem II antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009839
name: SCF complex substrate recognition subunit
namespace: cellular_component
def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use the cellular component term 'SCF ubiquitin ligase complex ; GO:0019005'.
is_obsolete: true

[Term]
id: GO:0009840
name: chloroplastic endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009841
name: mitochondrial endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0009842
name: cyanelle
namespace: cellular_component
def: "Plastid type found in Glaucophyta having unstacked thylakoid membranes bearing phycobilisomes; cyanelles are bound by a double membrane and a peptidoglycan layer." [ISBN:052131687]
subset: gosubset_prok
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009843
name: thylakoid (sensu Glaucocystophyceae)
namespace: cellular_component
def: "Photosynthetic membrane resembling that of cyanobacteria found in the cyanelles of certain algae. As in, but not restricted to, the glaucocystophytes (Glaucocystophyceae, ncbi_taxonomy_id:38254)." [GOC:lr]
subset: gosubset_prok
is_a: GO:0009579 ! thylakoid
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0009897
name: external side of plasma membrane
namespace: cellular_component
def: "The side of the plasma membrane that is opposite to the side that faces the cytoplasm." [GOC:tb]
subset: gosubset_prok
exact_synonym: "outer surface of cytoplasmic membrane" []
broad_synonym: "juxtamembrane" []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0009898
name: internal side of plasma membrane
namespace: cellular_component
def: "The side of the plasma membrane that faces the cytoplasm." [GOC:tb]
subset: gosubset_prok
broad_synonym: "juxtamembrane" []
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0009921
name: auxin efflux carrier complex
namespace: cellular_component
def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0009923
name: fatty acid elongase complex
namespace: cellular_component
def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb]
is_a: GO:0031373 ! cytosolic fatty acid synthase complex

[Term]
id: GO:0009925
name: basal plasma membrane
namespace: cellular_component
def: "Part of the plasma membrane at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016323 ! basolateral plasma membrane
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0009928
name: cell surface (sensu Magnoliophyta)
namespace: cellular_component
def: "The external part of the cell wall and/or plasma membrane. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:sm]
is_a: GO:0009986 ! cell surface

[Term]
id: GO:0009929
name: cell surface (sensu Magnoliophyta)
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it already exists. To update annotations, use the cellular component term 'cell surface (sensu Magnoliophyta) ; GO:0009928'.
is_obsolete: true

[Term]
id: GO:0009930
name: longitudinal side of cell surface (sensu Magnoliophyta)
namespace: cellular_component
def: "The side of the cell parallel to the zygotic axis. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:sm]
is_a: GO:0009928 ! cell surface (sensu Magnoliophyta)

[Term]
id: GO:0009941
name: chloroplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]
is_a: GO:0009526 ! plastid envelope
is_a: GO:0016020 ! membrane
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009986
name: cell surface
namespace: cellular_component
def: "The external part of the cell wall and/or cell membrane." [GOC:jl, GOC:sm]
comment: Note that this term is intended to annotate gene products that are attached to the plasma membrane or cell wall.
subset: goslim_goa
subset: gosubset_prok
exact_synonym: "cell associated" []
exact_synonym: "cell bound" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0010005
name: cortical microtubule (sensu Viridiplantae)
namespace: cellular_component
def: "Arrays of microtubules underlying and connected to the plasma membrane of plant cells, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell(and root). It influences the direction of cellulose microfibril deposition. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [ISBN:0943088399]
is_a: GO:0005874 ! microtubule
is_a: GO:0030981 ! cortical microtubule cytoskeleton

[Term]
id: GO:0010006
name: Toc complex
namespace: cellular_component
def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010007
name: magnesium chelatase complex
namespace: cellular_component
def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180]
is_a: GO:0043234 ! protein complex
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0010008
name: endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endosome." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0010009
name: external side of endosome membrane
namespace: cellular_component
def: "The external (cytoplasmic face) of an endosome membrane." [GOC:lr]
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0010168
name: ER body
namespace: cellular_component
def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182]
exact_synonym: "endoplasmic reticulum body" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0010169
name: myrosinase complex
namespace: cellular_component
def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349]
exact_synonym: "thioglucosidase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0010170
name: glucose-1-phosphate adenylyltransferase complex
namespace: cellular_component
def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0010240
name: pyruvate dehydrogenase complex (sensu Viridiplantae)
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [PMID:9393637]
is_a: GO:0044435 ! plastid part
is_a: GO:0045254 ! pyruvate dehydrogenase complex

[Term]
id: GO:0010278
name: chloroplast outer membrane translocon
namespace: cellular_component
def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010282
name: senescence associated vacuole
namespace: cellular_component
def: "Vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448]
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0010287
name: plastoglobule
namespace: cellular_component
def: "Plastoglobules (PG) are lipoprotein particles present in chloroplasts. They are rich in non-polar lipids (triacylglycerols, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:TAIR_curator, PMID:16461379]
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_yeast
is_a: GO:0016020 ! membrane

[Term]
id: GO:0012506
name: vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0012505 ! endomembrane system
relationship: part_of GO:0031988 ! membrane-bound vesicle

[Term]
id: GO:0012507
name: ER to Golgi transport vesicle membrane
namespace: cellular_component
alt_id: GO:0030664
def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai]
exact_synonym: "COPII coated vesicle membrane" []
exact_synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" []
exact_synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" []
exact_synonym: "ER-Golgi transport vesicle membrane" []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030134 ! ER to Golgi transport vesicle

[Term]
id: GO:0012508
name: Golgi to ER transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai]
exact_synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" []
exact_synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" []
exact_synonym: "Golgi-ER transport vesicle membrane" []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030663 ! COPI coated vesicle membrane
relationship: part_of GO:0030142 ! Golgi to ER transport vesicle

[Term]
id: GO:0012509
name: inter-Golgi transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030663 ! COPI coated vesicle membrane
relationship: part_of GO:0030143 ! inter-Golgi transport vesicle

[Term]
id: GO:0012510
name: trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai]
exact_synonym: "TGN transport vesicle membrane" []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030665 ! clathrin coated vesicle membrane
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0012511
name: lipid storage body (sensu Viridiplantae)
namespace: cellular_component
alt_id: GO:0009520
def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. A droplet of triacylglycerol surrounded by a monolayer of phospholipids, interacting with the triacylglycerols and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [ISBN:0943088372]
exact_synonym: "oil body" []
exact_synonym: "oleosome" []
exact_synonym: "spherosome" []
is_a: GO:0005811 ! lipid particle
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0014069
name: postsynaptic density
namespace: cellular_component
def: "The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases." [GOC:ef, GOC:jic, http://molneuro.kaist.ac.kr/psd, http://wikipedia.org, PMID:14532281]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0015030
name: Cajal body
namespace: cellular_component
def: "A class of nuclear body, first seen after silver staining by Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [http://genetics.cwru.edu/matera3.html, PMID:10944589, PMID:11031238, PMID:7559785]
exact_synonym: "coiled body" []
exact_synonym: "Gems" []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0015050
name: methane monooxygenase complex
namespace: cellular_component
def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0015627
name: type II protein secretion system complex
namespace: cellular_component
subset: gosubset_prok
exact_synonym: "type II protein (Sec) secretion system complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0015629
name: actin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0395825172]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015630
name: microtubule cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015934
name: large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005840 ! ribosome

[Term]
id: GO:0015935
name: small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a ribosome." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005840 ! ribosome

[Term]
id: GO:0016006
name: Nebenkern
namespace: cellular_component
def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
is_a: GO:0005739 ! mitochondrion

[Term]
id: GO:0016007
name: mitochondrial derivative
namespace: cellular_component
def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma]
is_a: GO:0005739 ! mitochondrion

[Term]
id: GO:0016008
name: major mitochondrial derivative
namespace: cellular_component
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016009
name: minor mitochondrial derivative
namespace: cellular_component
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016010
name: dystrophin-associated glycoprotein complex
namespace: cellular_component
def: "A multiprotein complex that forms the critical link between the cytoskeleton and extracellular matrix; typical of, but not confined, to muscle cells. The constituents of the complex are somewhat tissue specific. The rod-like dystrophin forms a link between the actin cytoskeleton and the plasma membrane; links between dystrophin and the extracellular matrix are provided by the sarcoglycan complex." [http://www.dmd.nl/dap.html#dg]
exact_synonym: "DGC complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0016011
name: dystroglycan complex
namespace: cellular_component
def: "Includes alpha- and beta-dystroglycan; alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [http://www.dmd.nl/dap.html#dg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016012
name: sarcoglycan complex
namespace: cellular_component
def: "Formed of five N-glycosylated sarcoglycans: alpha-, beta-, gamma-, delta-, and epsilon sarcoglycan, single-pass transmembrane proteins that form a complex which is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [http://www.dmd.nl/dap.html#dg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016011 ! dystroglycan complex

[Term]
id: GO:0016013
name: syntrophin complex
namespace: cellular_component
def: "Includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/dap.html#dg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016014
name: dystrobrevin complex
namespace: cellular_component
def: "A complex of alpha- and beta-dystrobrevin." [http://www.dmd.nl/dap.html#dg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_goa
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0016021
name: integral to membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]
subset: gosubset_prok
exact_synonym: "transmembrane" []
is_a: GO:0031224 ! intrinsic to membrane

[Term]
id: GO:0016022
name: endoplasmic reticulum cisterna
namespace: cellular_component
def: "The flattened sac-like space enclosed between paired membrane of the endoplasmic reticulum." [ISBN:0198506732]
exact_synonym: "ER cisterna" []
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0016023
name: cytoplasmic membrane-bound vesicle
namespace: cellular_component
def: "A membrane-bound vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
exact_synonym: "cytoplasmic membrane bound vesicle" []
is_a: GO:0031410 ! cytoplasmic vesicle
is_a: GO:0031988 ! membrane-bound vesicle
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0016027
name: inaD signaling complex
namespace: cellular_component
def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [FB:FBrf0105321, GOC:hb, PMID:9010208]
exact_synonym: "inaD signalling complex" []
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0016028
name: rhabdomere
namespace: cellular_component
def: "The specialized microvillar organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, PMID:8646774]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016029
name: subrhabdomeral cisterna
namespace: cellular_component
def: "The internal stores of calcium found at the base of the rhabdomere." [PMID:8646774]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0016035
name: zeta DNA polymerase complex
namespace: cellular_component
def: "A low fidelity DNA-directed DNA polymerase that functions during replication, to promote the extension of forks whose progression is stopped for any reason; a non-processive enzyme with no 3'-5' exonuclease activity; possesses deoxycytidyl transferase activity, incorporating deoxycytidyl opposite abasic sites. Functions during DNA repair and mutagenesis. Composed of two subunits." [PMID:11205328]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016190
name: clathrin coat
namespace: cellular_component
def: "OBSOLETE. The coat of coated vesicles, coated pits and synaptic vesicles, a polyhedral lattice of subunits; each subunit, or clathrin triskelion, consists of three clathrin heavy chains and three clathrin light chains." [ISBN:0198547684]
comment: This term was made obsolete because it was defined incorrectly. To update annotations, use the cellular component term 'clathrin coat ; GO:0030118'.
is_obsolete: true

[Term]
id: GO:0016222
name: procollagen-proline, 2-oxoglutarate-4-dioxygenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate." [EC:1.14.11.2]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0016234
name: inclusion body
namespace: cellular_component
def: "Intracellular foci at which aggregated proteins have been sequestered." [PMID:11121744]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0016235
name: aggresome
namespace: cellular_component
def: "An inclusion body resulting from dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744]
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0016272
name: prefoldin complex
namespace: cellular_component
def: "A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, UniProtKB:O15212]
subset: gosubset_prok
narrow_synonym: "GIM complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0016281
name: eukaryotic translation initiation factor 4F complex
namespace: cellular_component
def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, UniProtKB:P41110]
exact_synonym: "eIF-4F" []
broad_synonym: "eukaryotic translation initiation factor 4 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0016282
name: eukaryotic 43S preinitiation complex
namespace: cellular_component
def: "The 43S preinitiation complex is the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound to the initiator tRNA." [GOC:hb]
exact_synonym: "eukaryotic 43S pre-initiation complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0016283
name: eukaryotic 48S initiation complex
namespace: cellular_component
def: "The 48S initiation complex is composed of the 40S ribosomal subunit, the initiator tRNA, and the mRNA." [GOC:hb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0016323
name: basolateral plasma membrane
namespace: cellular_component
def: "Part of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016324
name: apical plasma membrane
namespace: cellular_component
def: "Part of the plasma membrane at the apical end of the cell." [GOC:curators]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0016327
name: apicolateral plasma membrane
namespace: cellular_component
def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
subset: gosubset_prok
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016328
name: lateral plasma membrane
namespace: cellular_component
def: "The membranes on the sides of epithelial cells which lie at the interface of adjacent cells." [GOC:hb]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016341
name: other collagen
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term. To update annotations, use the cellular component term 'collagen ; GO:0005581'.
is_obsolete: true

[Term]
id: GO:0016342
name: catenin complex
namespace: cellular_component
def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0016363
name: nuclear matrix
namespace: cellular_component
def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0016442
name: RNA-induced silencing complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
exact_synonym: "RISC complex" []
is_a: GO:0031332 ! RNAi effector complex

[Term]
id: GO:0016456
name: dosage compensation complex (sensu Insecta)
namespace: cellular_component
def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:ma]
is_a: GO:0046536 ! dosage compensation complex

[Term]
id: GO:0016459
name: myosin complex
namespace: cellular_component
def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0016460
name: myosin II complex
namespace: cellular_component
def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
related_synonym: "conventional myosin" []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016461
name: unconventional myosin complex
namespace: cellular_component
alt_id: GO:0005860
def: "A portmanteau term for myosins other than myosin II." [GOC:ma]
comment: Note that this term is retained because it is widely used by biologists.
related_synonym: "non-muscle myosin" []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016465
name: chaperonin ATPase complex
namespace: cellular_component
def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0016469
name: proton-transporting two-sector ATPase complex
namespace: cellular_component
def: "A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F0, V0, A0) and a cytoplasmic compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archebacterial) enzymes have a similar structure but, under physiological conditions, they pump hydrogen ion rather than synthesize ATP." [EC:3.6.3.14]
subset: gosubset_prok
related_synonym: "vacuolar hydrogen-transporting ATPase" []
exact_synonym: "hydrogen-transporting two-sector ATPase complex" []
is_a: GO:0016021 ! integral to membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0016471
name: hydrogen-translocating V-type ATPase complex
namespace: cellular_component
def: "Complex composed of a V1 and a V0 domain to form an active V-type ATPase that functions as a proton pump." [GOC:rb, PMID:10224039, TC:3.A.2.-.-]
comment: See also the cellular component terms 'hydrogen-transporting ATPase V1 domain ; GO:0000221' and 'hydrogen-transporting ATPase V0 domain ; GO:0000220' and the molecular function term 'hydrogen-transporting ATPase activity, rotational mechanism ; GO:0046961'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0016472
name: sodium-transporting two-sector ATPase complex
namespace: cellular_component
def: "A multisubunit non-phosphorylated ATPase that is involved in the transport of ions." [EC:3.6.3.15]
is_a: GO:0016021 ! integral to membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0016473
name: sodium-translocating F-type ATPase complex
namespace: cellular_component
is_a: GO:0016472 ! sodium-transporting two-sector ATPase complex

[Term]
id: GO:0016474
name: sodium-translocating V-type ATPase complex
namespace: cellular_component
is_a: GO:0016472 ! sodium-transporting two-sector ATPase complex

[Term]
id: GO:0016507
name: fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]
related_synonym: "trifunctional enzyme" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0016513
name: core-binding factor complex
namespace: cellular_component
def: "A heterodimer with alpha- and beta-subunits that binds the core site 5'-PYGPYGGT-3' of several enhancers and promoters; the beta-subunit enhances the DNA binding of the alpha-subunit." [UniProtKB:Q08024]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0016514
name: SWI/SNF complex
namespace: cellular_component
def: "Any of a family of protein complexes that regulate transcription by remodeling chromatin. Swi/Snf complexes comprise nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components." [GOC:mah, PMID:12672490]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0016516
name: interleukin-4 receptor complex
namespace: cellular_component
def: "Complexes that bind interleukin-4; consist of alpha, beta, and gamma chains and exist in three forms, one containing extracellular transmembrane and cytoplasmic domains, one lacking the cytoplasmic domain and a third that is secreted." [UniProtKB:P16382]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0016528
name: sarcoplasm
namespace: cellular_component
def: "The cytoplasm of a muscle fiber; includes the sarcoplasmic reticulum." [ISBN:0198547684]
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0016529
name: sarcoplasmic reticulum
namespace: cellular_component
alt_id: GO:0008221
def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle fiber; continuous over large portions of the cell and with the nuclear envelope; an endoplasmic reticulum specialized for the sequestration of calcium ions." [ISBN:0124325653, ISBN:0198547684]
comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'.
is_a: GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0016533
name: cyclin-dependent protein kinase 5 activator complex
namespace: cellular_component
def: "Activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [UniProtKB:Q62938]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0016580
name: Sin3 complex
namespace: cellular_component
def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422]
is_a: GO:0000118 ! histone deacetylase complex

[Term]
id: GO:0016581
name: NuRD complex
namespace: cellular_component
def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in both vertebrates and invertebrates. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021]
exact_synonym: "Mi-2 complex" []
exact_synonym: "NRD complex" []
exact_synonym: "nucleosome remodeling and histone deacetylation complex" []
is_a: GO:0000118 ! histone deacetylase complex

[Term]
id: GO:0016585
name: chromatin remodeling complex
namespace: cellular_component
alt_id: GO:0005679
def: "Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah]
exact_synonym: "chromatin remodelling complex" []
exact_synonym: "nucleosome remodeling complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016586
name: RSC complex
namespace: cellular_component
def: "A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [PMID:11937489, PMID:12672490, PMID:15870268, PMID:8980231]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0016587
name: ISW1 complex
namespace: cellular_component
def: "A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure." [GOC:mah, PMID:15020051]
is_a: GO:0031010 ! ISWI complex

[Term]
id: GO:0016589
name: NURF complex
namespace: cellular_component
def: "A four subunit ISWI-containing protein complex that facilitates nucleosome mobility and transcriptional activation in an ATP-dependent manner. In contrast to other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones." [GOC:bf, PMID:10779516, PMID:11279013]
exact_synonym: "nucleosome remodeling factor complex" []
is_a: GO:0031010 ! ISWI complex

[Term]
id: GO:0016590
name: ACF complex
namespace: cellular_component
def: "A chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. In Drosophila, the complex comprises ACF1 and ISWI." [GOC:bf, PMID:12192034]
exact_synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" []
is_a: GO:0005678 ! chromatin assembly complex

[Term]
id: GO:0016591
name: DNA-directed RNA polymerase II, holoenzyme
namespace: cellular_component
def: "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, http://en.wikipedia.org/, PMID:15196470]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016592
name: Srb-mediator complex
namespace: cellular_component
def: "A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins." [PMID:9396788]
is_a: GO:0000119 ! mediator complex

[Term]
id: GO:0016593
name: Cdc73/Paf1 complex
namespace: cellular_component
def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Hpr1p, Ccr4p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]
is_a: GO:0008023 ! transcription elongation factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0016599
name: caveolar membrane
namespace: cellular_component
def: "The membrane area of caveolae, the small pits, depressions, or invaginations found in the plasma membrane of cells. Caveolar membrane is characterized by the presence of caveolins, which constitute the major protein component of caveolar membrane in vivo." [PMID:11551396, PMID:12217512]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0016600
name: flotillin complex
namespace: cellular_component
def: "A heteromeric complex of flotillin 1, flotillin 2, caveolin 1 and caveolin 2 within the caveolar membrane." [UniProtKB:O61491]
comment: See also the cellular component term 'caveolar membrane ; GO:0016599'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016599 ! caveolar membrane

[Term]
id: GO:0016602
name: CCAAT-binding factor complex
namespace: cellular_component
def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [PMID:7828851]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0016604
name: nuclear body
namespace: cellular_component
def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016605
name: PML body
namespace: cellular_component
def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585]
related_synonym: "nuclear dot" []
exact_synonym: "ND10" []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016606
name: Lands
namespace: cellular_component
def: "A class of nuclear body (Lands = LYSP100-associated nuclear domains); they are globular, electron-dense structures that may traffic between the nucleus and cytoplasm; they react against SP140 auto-antibodies." [UniProtKB:Q13342]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016607
name: nuclear speck
namespace: cellular_component
def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
related_synonym: "speckle focus" []
exact_synonym: "nuclear speckle" []
exact_synonym: "nuclear speckles" []
exact_synonym: "splicing speckle" []
narrow_synonym: "speckle domain" []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016610
name: nitrogenase complex
namespace: cellular_component
def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0016611
name: iron-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850]
comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells.
subset: gosubset_prok
related_synonym: "iron-iron nitrogenase activity" []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016612
name: molybdenum-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1]
subset: gosubset_prok
related_synonym: "molybdenum-iron nitrogenase activity" []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016613
name: vanadium-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027]
subset: gosubset_prok
related_synonym: "vanadium-iron nitrogenase activity" []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016914
name: follicle-stimulating hormone complex
namespace: cellular_component
def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0016935
name: glycine-gated chloride channel complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0016938
name: kinesin I complex
namespace: cellular_component
def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016939
name: kinesin II complex
namespace: cellular_component
def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016942
name: insulin-like growth factor binding protein complex
namespace: cellular_component
def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl]
exact_synonym: "IGF binding protein complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0017023
name: myosin phosphatase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex

[Term]
id: GO:0017052
name: insulin-like growth factor binding protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component term 'insulin-like growth factor binding protein complex ; GO:0016942' and its children.
is_obsolete: true

[Term]
id: GO:0017053
name: transcriptional repressor complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0017054
name: negative cofactor 2 complex
namespace: cellular_component
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0017059
name: serine C-palmitoyltransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0017071
name: intracellular cyclic nucleotide activated cation channel complex
namespace: cellular_component
is_a: GO:0016021 ! integral to membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0017086
name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex
namespace: cellular_component
alt_id: GO:0031212
def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamin diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4]
exact_synonym: "BCADH" []
exact_synonym: "branched-chain alpha-ketoacid dehydrogenase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017087
name: mitochondrial processing peptidase complex
namespace: cellular_component
def: "This enzyme complex catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [EC:3.4.24.64]
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017090
name: meprin A complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18]
is_a: GO:0016021 ! integral to membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0017101
name: aminoacyl-tRNA synthetase multienzyme complex
namespace: cellular_component
def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]
exact_synonym: "aminoacyl-tRNA synthetase complex" []
exact_synonym: "multisynthetase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0017102
name: methionyl glutamyl tRNA synthetase complex
namespace: cellular_component
def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0017109
name: glutamate-cysteine ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0017117
name: single-stranded DNA-dependent ATP-dependent DNA helicase complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0017119
name: Golgi transport complex
namespace: cellular_component
def: "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665]
exact_synonym: "COG complex" []
exact_synonym: "conserved oligomeric Golgi complex" []
narrow_synonym: "Sec34/35 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0017122
name: UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase complex
namespace: cellular_component
def: "Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide." [UniProtKB:O15294]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0017133
name: electron transfer flavoprotein complex (sensu Eukaryota)
namespace: cellular_component
def: "A protein complex found in eukaryotes containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [ISBN:0198506732]
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045251 ! electron transfer flavoprotein complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017146
name: N-methyl-D-aspartate selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the centre of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
exact_synonym: "NMDA-selective glutamate receptor " []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0017177
name: alpha-glucosidase II complex
namespace: cellular_component
def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]
comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term.
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0018444
name: translation release factor complex
namespace: cellular_component
def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
exact_synonym: "eukaryotic peptide chain release factor" []
broad_synonym: "peptide chain release factor" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0018994
name: polar granule
namespace: cellular_component
def: "A small protein-containing electron dense organelle, not surrounded by a membrane, that induces the formation of and becomes incorporated into germ cells." [GOC:bf, http://cancerweb.ncl.ac.uk/]
exact_synonym: "germline granule" []
broad_synonym: "nuage" []
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0045495 ! pole plasm

[Term]
id: GO:0018995
name: host
namespace: cellular_component
def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732]
exact_synonym: "host organism" []
is_a: GO:0043245 ! extraorganismal space

[Term]
id: GO:0018998
name: metaxin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider the cellular component term 'mitochondrial outer membrane ; GO:0005741'.
is_obsolete: true

[Term]
id: GO:0019005
name: SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
exact_synonym: "CDL1 complex" []
exact_synonym: "CRL1 complex" []
exact_synonym: "Cul1-RING ubiquitin ligase complex" []
exact_synonym: "cullin-RING ligase 1" []
exact_synonym: "SCF complex" []
exact_synonym: "Skp1/Cul1/F-box protein complex" []
narrow_synonym: "SCF complex substrate recognition subunit" []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0019008
name: molybdopterin synthase complex
namespace: cellular_component
alt_id: GO:0019009
def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772]
subset: gosubset_prok
exact_synonym: "molybdopterin converting factor complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0019012
name: virion
namespace: cellular_component
def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325]
exact_synonym: "complete virus particle" []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0019013
name: viral nucleocapsid
namespace: cellular_component
alt_id: GO:0019014
def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
exact_synonym: "nucleocapsid" []
broad_synonym: "core" []
is_a: GO:0044423 ! virion part
relationship: part_of GO:0046728 ! viral capsid (sensu Retroviridae)

[Term]
id: GO:0019015
name: viral genome
namespace: cellular_component
def: "The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019016
name: non-segmented viral genome
namespace: cellular_component
def: "A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019017
name: segmented viral genome
namespace: cellular_component
def: "A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019018
name: bipartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019019
name: tripartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019020
name: multipartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019021
name: DNA viral genome
namespace: cellular_component
def: "A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019022
name: RNA viral genome
namespace: cellular_component
def: "A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019023
name: dsRNA viral genome
namespace: cellular_component
def: "A viral genome composed of double stranded RNA." [ISBN:0121585336]
is_a: GO:0019022 ! RNA viral genome

[Term]
id: GO:0019024
name: ssRNA viral genome
namespace: cellular_component
def: "A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336]
is_a: GO:0019022 ! RNA viral genome

[Term]
id: GO:0019025
name: positive sense viral genome
namespace: cellular_component
def: "A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019026
name: negative sense viral genome
namespace: cellular_component
def: "A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019027
name: ambisense viral genome
namespace: cellular_component
def: "A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019028
name: viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [ISBN:0198506732]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019029
name: helical viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X]
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019030
name: icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Tobacco satellite necrosis virus has such a capsid structure." [ISBN:0198506732, ISBN:071673706X]
exact_synonym: "quasispherical viral capsid" []
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019031
name: viral envelope
namespace: cellular_component
def: "The lipid bilayer and associated glycoproteins that surround many types of virus particle." [ISBN:0781718325]
related_synonym: "viral glycoprotein" []
exact_synonym: "viral membrane" []
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019032
name: viral glycoprotein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a type of gene product and not a location or complex. To update annotations, consider the cellular component term 'viral envelope ; GO:0019031'.
is_obsolete: true

[Term]
id: GO:0019033
name: viral tegument
namespace: cellular_component
def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019034
name: viral replication complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019035
name: viral integration complex
namespace: cellular_component
def: "Virus-specific complex of protein required for integrating viral genomes into the host genome." [ISBN:0781718325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019036
name: viral transcriptional complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019037
name: viral assembly intermediate
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019038
name: provirus
namespace: cellular_component
def: "The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0019183
name: histamine-gated chloride channel complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0019185
name: snRNA-activating protein complex
namespace: cellular_component
def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788]
exact_synonym: "SNAPc" []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0019197
name: phosphoenolpyruvate-dependent sugar phosphotransferase complex
namespace: cellular_component
def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019717
name: synaptosome
namespace: cellular_component
def: "Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0019718
name: rough microsome
namespace: cellular_component
def: "Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005792 ! microsome

[Term]
id: GO:0019719
name: smooth microsome
namespace: cellular_component
def: "Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005792 ! microsome

[Term]
id: GO:0019773
name: proteasome core complex, alpha-subunit complex (sensu Eukaryota)
namespace: cellular_component
def: "Refers to the subunits that constitute the outer rings of the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jl, GOC:rb, PMID:10854779]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005839 ! proteasome core complex (sensu Eukaryota)

[Term]
id: GO:0019774
name: proteasome core complex, beta-subunit complex (sensu Eukaryota)
namespace: cellular_component
def: "Refers to the subunits that constitute the inner rings of the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jl, GOC:rb, PMID:10854779]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005839 ! proteasome core complex (sensu Eukaryota)

[Term]
id: GO:0019804
name: quinolinate synthetase complex
namespace: cellular_component
def: "A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902]
comment: See also the molecular function term 'L-aspartate oxidase activity ; GO:0008734'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019812
name: Type I site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748]
subset: gosubset_prok
exact_synonym: "Type I restriction enzyme complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019813
name: Type III site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
exact_synonym: "Type III restriction enzyme complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019814
name: immunoglobulin complex
namespace: cellular_component
def: "A multiprotein complex that functions as an antibody. Immunoglobulins (Igs) are composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. The classes of Ig are IgA, IgD, IgE, IgG and IgM; they may be embedded in the plasma membrane or circulate in the blood or lymph." [GOC:jl, ISBN:0140512713]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0019815
name: B cell receptor complex
namespace: cellular_component
alt_id: GO:0042570
def: "A membrane-bound antigen receptor complex consisting in its basic form of an antigen-binding subunit (the membrane immunoglobulin or mIg), comprised of two identical heavy chains and two identical light chains held together by disulfide bonds, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [ISBN:0781735149]
related_synonym: "B cell receptor accessory molecule complex" []
related_synonym: "BCR" []
exact_synonym: "B lymphocyte receptor complex" []
exact_synonym: "B-cell receptor complex" []
exact_synonym: "B-lymphocyte receptor complex" []
exact_synonym: "immunoglobulin complex, membrane bound" []
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0001772 ! immunological synapse

[Term]
id: GO:0019816
name: B cell receptor accessory molecule complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecule and not a location or complex. To update annotations, consider the cellular component term 'B cell receptor complex ; GO:0019815'.
is_obsolete: true

[Term]
id: GO:0019819
name: P1 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
broad_synonym: "peroxisome vesicle" []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019820
name: P2 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
broad_synonym: "peroxisome vesicle" []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019821
name: P3 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
broad_synonym: "peroxisome vesicle" []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019822
name: P4 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
broad_synonym: "peroxisome vesicle" []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019823
name: P5 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'.
broad_synonym: "peroxisome vesicle" []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019824
name: P6 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'.
broad_synonym: "peroxisome vesicle" []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019861
name: flagellum
namespace: cellular_component
alt_id: GO:0008223
def: "Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [http://haven.isb-sib.ch/spdocann//dicterms.txt, UniProtKB:kwdictionary]
subset: gosubset_prok
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0019866
name: organelle inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah]
comment: See also the cellular component term 'outer membrane ; GO:0019867'.
subset: gosubset_prok
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0019867
name: outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [http://haven.isb-sib.ch/spdocann//dicterms.txt, UniProtKB:kwdictionary]
subset: gosubset_prok
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0019897
name: extrinsic to plasma membrane
namespace: cellular_component
alt_id: GO:0000157
def: "Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
exact_synonym: "peripheral plasma membrane protein" []
broad_synonym: "juxtamembrane" []
is_a: GO:0019898 ! extrinsic to membrane
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0019898
name: extrinsic to membrane
namespace: cellular_component
alt_id: GO:0030396
def: "Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/]
comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
subset: gosubset_prok
related_synonym: "GPI-anchored membrane-bound receptor" []
exact_synonym: "peripheral membrane protein" []
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0019907
name: cyclin-dependent protein kinase activating kinase holoenzyme complex
namespace: cellular_component
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019908
name: nuclear cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc]
broad_synonym: "CDK holoenzyme" []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019910
name: pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Eukaryota)
namespace: cellular_component
def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [UniProtKB:P35816]
comment: See also the cellular component term 'pyruvate dehydrogenase complex (sensu Eukaryota) ; GO:0005967'.
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0020002
name: host cell plasma membrane
namespace: cellular_component
def: "The plasma membrane surrounding a host cell." [GOC:mb]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0043657 ! host cell

[Term]
id: GO:0020003
name: parasitophorous vacuole
namespace: cellular_component
def: "Vacuole within a host cell in which a parasite resides." [GOC:mb]
is_a: GO:0005773 ! vacuole
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0043656 ! intracellular region of host

[Term]
id: GO:0020004
name: parasitophorous vacuolar space
namespace: cellular_component
def: "Space between a parasite plasma membrane and the parasitophorous vacuolar membrane." [GOC:mb]
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0020003 ! parasitophorous vacuole

[Term]
id: GO:0020005
name: parasitophorous vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a parasitophorous vacuole." [GOC:mb]
is_a: GO:0005774 ! vacuolar membrane
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0020003 ! parasitophorous vacuole

[Term]
id: GO:0020006
name: parasitophorous vacuolar membrane network
namespace: cellular_component
def: "Tubular network of extensions from the parasitophorous vacuolar membrane that protrude into the host cytoplasm." [PMID:3528173]
narrow_synonym: "tubulovesicular network" []
is_a: GO:0005774 ! vacuolar membrane
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0020005 ! parasitophorous vacuolar membrane

[Term]
id: GO:0020007
name: apical complex
namespace: cellular_component
def: "Protruding complex at the anterior end of some life cycle stages of all apicomplexan parasites, involved in both the attachment and penetration of the host cell by the parasite." [GOC:mb]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0020008
name: rhoptry
namespace: cellular_component
def: "The tubular or sacular organelle of an apical complex." [ISBN:0521664470]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020009
name: microneme
namespace: cellular_component
def: "Elongated tubular organelle arranged longitudinally in the apical complex of an apicomplexan parasite." [ISBN:0521664470]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020010
name: conoid
namespace: cellular_component
def: "Coiled microtubules within both the polar and basal rings of the apical complex of an apicomplexan parasite." [ISBN:0521664470]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020031 ! polar ring of apical complex
relationship: part_of GO:0020032 ! basal ring of apical complex

[Term]
id: GO:0020011
name: apicoplast
namespace: cellular_component
def: "The plastid organelle found in apicomplexans." [ISBN:0521664470]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0020015
name: glycosome
namespace: cellular_component
def: "Membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb]
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0020016
name: flagellar pocket
namespace: cellular_component
def: "Invagination of the plasma membrane from which a flagellum protrudes." [GOC:mb]
is_a: GO:0044442 ! flagellar part (sensu Eukaryota)

[Term]
id: GO:0020017
name: flagellar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the flagellum; continuous with the plasma membrane." [GOC:mb]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044442 ! flagellar part (sensu Eukaryota)
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0020018
name: flagellar pocket membrane
namespace: cellular_component
def: "That part of the plasma membrane found in the flagellar pocket." [GOC:mb]
is_a: GO:0020017 ! flagellar membrane
relationship: part_of GO:0020016 ! flagellar pocket

[Term]
id: GO:0020020
name: food vacuole
namespace: cellular_component
alt_id: GO:0005772
def: "Vacuole within a parasite used for digestion of the host cell cytoplasm." [GOC:mb]
exact_synonym: "digestive vacuole" []
exact_synonym: "food vacuole (sensu Apicomplexa)" []
is_a: GO:0032010 ! phagolysosome

[Term]
id: GO:0020022
name: acidocalcisome
namespace: cellular_component
def: "An electron-dense acidic organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0020023
name: kinetoplast
namespace: cellular_component
def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb]
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0020025
name: subpellicular microtubule
namespace: cellular_component
def: "Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid." [GOC:mb]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020026
name: dense granule (sensu Apicomplexa)
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell. As in, but not restricted to, the apicomplexans (Apicomplexa, ncbi_taxonomy_id:5794)." [GOC:mb]
exact_synonym: "dense body" []
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0020030
name: infected host cell surface knob
namespace: cellular_component
def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte." [GOC:mb]
exact_synonym: "knob (sensu Plasmodium)" []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0030430 ! host cell cytoplasm

[Term]
id: GO:0020031
name: polar ring of apical complex
namespace: cellular_component
def: "Electron dense ring at the most anterior position of an invasive life cycle stage of an apicomplexan parasite." [GOC:mb]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020032
name: basal ring of apical complex
namespace: cellular_component
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020036
name: Maurer's cleft
namespace: cellular_component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0030430 ! host cell cytoplasm

[Term]
id: GO:0020038
name: subpellicular network
namespace: cellular_component
def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0020039
name: pellicle
namespace: cellular_component
def: "The cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mb]
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0030008
name: TRAPP complex
namespace: cellular_component
def: "A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion." [PMID:9564032]
exact_synonym: "transport protein particle" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0005801 ! Golgi cis face

[Term]
id: GO:0030014
name: CCR4-NOT complex
namespace: cellular_component
def: "A large multimeric transcription factor complex that can regulate transcription positively or negatively; consists of a core complex plus additional proteins; may interact with other proteins to control initiation of transcription. In Saccharomyces the core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p; Caf4p, Caf16p, and several less well characterized proteins." [PMID:11113136]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0030015
name: CCR4-NOT core complex
namespace: cellular_component
def: "The core of the CCR4-NOT transcription factor complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p." [PMID:11113136]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0030014 ! CCR4-NOT complex

[Term]
id: GO:0030016
name: myofibril
namespace: cellular_component
def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
exact_synonym: "striated muscle fiber" []
exact_synonym: "striated muscle fibre" []
is_a: GO:0043292 ! contractile fiber

[Term]
id: GO:0030017
name: sarcomere
namespace: cellular_component
def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0030018
name: Z disc
namespace: cellular_component
def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [ISBN:0815316194]
exact_synonym: "Z line" []
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0030027
name: lamellipodium
namespace: cellular_component
def: "A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [ISBN:0815316194]
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031252 ! leading edge

[Term]
id: GO:0030054
name: cell junction
namespace: cellular_component
def: "A specialized region of connection between two cells or between a cell and the extracellular matrix." [ISBN:0198506732]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0030055
name: cell-matrix junction
namespace: cellular_component
def: "A specialized region of connection between a cell and the extracellular matrix." [GOC:hb]
is_a: GO:0030054 ! cell junction
relationship: part_of GO:0016323 ! basolateral plasma membrane

[Term]
id: GO:0030056
name: hemidesmosome
namespace: cellular_component
def: "Point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments." [ISBN:0815316208]
is_a: GO:0030055 ! cell-matrix junction
relationship: part_of GO:0009925 ! basal plasma membrane

[Term]
id: GO:0030057
name: desmosome
namespace: cellular_component
def: "Button-like point of intercellular contact through which the intermediate filaments of adjacent cells are connected indirectly." [ISBN:0815316208]
exact_synonym: "macula adherens" []
exact_synonym: "spot desmosome" []
is_a: GO:0005911 ! intercellular junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0030061
name: mitochondrial crista
namespace: cellular_component
def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
exact_synonym: "mitochondrial cristae" []
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0030062
name: tricarboxylic acid cycle enzyme complex (sensu Eukaryota)
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
exact_synonym: "TCA cycle enzyme complex (sensu Eukaryota)" []
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0030063
name: murein sacculus
namespace: cellular_component
def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891]
comment: This term was made obsolete because it was defined inaccurately. To update annotations, consider the cellular component term 'cell wall (sensu Proteobacteria) ; GO:0009276'.
exact_synonym: "peptidoglycan layer" []
is_obsolete: true

[Term]
id: GO:0030064
name: cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254]
comment: This term was made obsolete because it was defined inaccurately. To update annotations, consider the cellular component term 'cell wall (sensu Proteobacteria) ; GO:0009276'.
is_obsolete: true

[Term]
id: GO:0030074
name: thylakoid (sensu Proteobacteria)
namespace: cellular_component
def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria. To update annotations, consider the biological process term 'chromatophore ; GO:0042716' and its children.
is_obsolete: true

[Term]
id: GO:0030075
name: thylakoid (sensu Cyanobacteria)
namespace: cellular_component
def: "A thylakoid; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117)." [GOC:mah]
subset: gosubset_prok
broad_synonym: "thylakoid (sensu Bacteria)" []
is_a: GO:0009579 ! thylakoid
is_a: GO:0042716 ! chromatophore
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0030076
name: light-harvesting complex
namespace: cellular_component
def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr]
subset: gosubset_prok
related_synonym: "antenna complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030077
name: light-harvesting complex (sensu Proteobacteria)
namespace: cellular_component
def: "A light-harvesting complex; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
subset: gosubset_prok
exact_synonym: "light-harvesting complex (sensu Gram-negative bacteria)" []
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0042716 ! chromatophore

[Term]
id: GO:0030078
name: light-harvesting complex, core complex
namespace: cellular_component
def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr]
is_a: GO:0030077 ! light-harvesting complex (sensu Proteobacteria)

[Term]
id: GO:0030079
name: light-harvesting complex, peripheral complex
namespace: cellular_component
def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr]
is_a: GO:0030077 ! light-harvesting complex (sensu Proteobacteria)

[Term]
id: GO:0030080
name: B875 antenna complex
namespace: cellular_component
def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [UniProtKB:kd]
exact_synonym: "LH1 complex" []
exact_synonym: "light harvesting complex I" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030078 ! light-harvesting complex, core complex

[Term]
id: GO:0030081
name: B800-820 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:lr, UniProtKB:kd]
exact_synonym: "LH3 complex" []
exact_synonym: "light harvesting complex III" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030082
name: B800-850 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:lr, UniProtKB:kd]
exact_synonym: "LH2 complex" []
exact_synonym: "light harvesting complex II" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030083
name: PSI associated light-harvesting complex I, LHCIa subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030084
name: PSI associated light-harvesting complex I, LHCIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030085
name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex

[Term]
id: GO:0030086
name: PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. To update annotations, use the cellular component term 'PSII associated light-harvesting complex II, core complex ; GO:0009655'.
is_obsolete: true

[Term]
id: GO:0030087
name: PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. To update annotations, use the cellular component term 'PSII associated light-harvesting complex II, core complex ; GO:0009655'.
is_obsolete: true

[Term]
id: GO:0030088
name: PSII associated light-harvesting complex II, core complex, LHCIId subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. To update annotations, use the cellular component term 'PSII associated light-harvesting complex II, core complex ; GO:0009655'.
is_obsolete: true

[Term]
id: GO:0030089
name: phycobilisome
namespace: cellular_component
def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [ISBN:0198506732]
subset: gosubset_prok
exact_synonym: "cyanosome" []
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044435 ! plastid part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009843 ! thylakoid (sensu Glaucocystophyceae)
relationship: part_of GO:0030075 ! thylakoid (sensu Cyanobacteria)

[Term]
id: GO:0030090
name: reaction center (sensu Proteobacteria)
namespace: cellular_component
def: "A complex of photosynthetic and accessory pigments and electron carriers that operate in sequence to perform the two light reactions of photosynthesis. As in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
subset: gosubset_prok
exact_synonym: "reaction center (sensu Gram-negative bacteria)" []
exact_synonym: "reaction centre (sensu Gram-negative bacteria)" []
exact_synonym: "reaction centre (sensu Proteobacteria)" []
is_a: GO:0009521 ! photosystem

[Term]
id: GO:0030093
name: photosystem I (sensu Viridiplantae)
namespace: cellular_component
def: "Photosystem I; as in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [GOC:jic]
is_a: GO:0009522 ! photosystem I
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009535 ! thylakoid membrane (sensu Viridiplantae)

[Term]
id: GO:0030094
name: photosystem I (sensu Cyanobacteria)
namespace: cellular_component
def: "Photosystem I; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117)." [GOC:jic]
subset: gosubset_prok
is_a: GO:0009522 ! photosystem I
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044435 ! plastid part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009843 ! thylakoid (sensu Glaucocystophyceae)
relationship: part_of GO:0030075 ! thylakoid (sensu Cyanobacteria)

[Term]
id: GO:0030095
name: photosystem II (sensu Viridiplantae)
namespace: cellular_component
def: "Photosystem II; as in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [GOC:jic]
is_a: GO:0009523 ! photosystem II
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009535 ! thylakoid membrane (sensu Viridiplantae)

[Term]
id: GO:0030096
name: photosystem II (sensu Cyanobacteria)
namespace: cellular_component
def: "Photosystem II; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117)." [GOC:jic]
subset: gosubset_prok
is_a: GO:0009523 ! photosystem II
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044435 ! plastid part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009843 ! thylakoid (sensu Glaucocystophyceae)
relationship: part_of GO:0030075 ! thylakoid (sensu Cyanobacteria)

[Term]
id: GO:0030112
name: glycocalyx
namespace: cellular_component
def: "The outermost external structures which surround a bacterial cell." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030113
name: capsule (sensu Bacteria)
namespace: cellular_component
def: "A protective structure surrounding some cells attached externally to the cell wall, often, but not always, constructed of polysaccharides. Capsules play an important role in pathogenicity, preventing phagocytosis by eukaryotic cells. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
is_a: GO:0030112 ! glycocalyx
is_a: GO:0042603 ! capsule

[Term]
id: GO:0030114
name: slime layer
namespace: cellular_component
def: "A protective structure surrounding some bacteria, usually composed of polysaccharides." [GOC:mlg, ISBN:0815108893]
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0030115
name: S-layer
namespace: cellular_component
def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0030117
name: membrane coat
namespace: cellular_component
def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
is_a: GO:0044425 ! membrane part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0048475 ! coated membrane

[Term]
id: GO:0030118
name: clathrin coat
namespace: cellular_component
def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]
exact_synonym: "clathrin cage" []
is_a: GO:0030117 ! membrane coat

[Term]
id: GO:0030119
name: membrane coat adaptor complex
namespace: cellular_component
def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles." [GOC:mah, PMID:10611976]
related_synonym: "clathrin adaptor" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0030117 ! membrane coat

[Term]
id: GO:0030120
name: vesicle coat
namespace: cellular_component
def: "A membrane coat found on a coated vesicle." [GOC:mah]
is_a: GO:0030117 ! membrane coat
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030662 ! coated vesicle membrane

[Term]
id: GO:0030121
name: AP-1 adaptor complex
namespace: cellular_component
def: "An adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network." [GOC:mah, PMID:10611976]
exact_synonym: "HA1" []
exact_synonym: "HA1 clathrin adaptor" []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle

[Term]
id: GO:0030122
name: AP-2 adaptor complex
namespace: cellular_component
def: "An adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles." [GOC:mah, PMID:10611976]
exact_synonym: "HA2" []
exact_synonym: "HA2 clathrin adaptor" []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle
relationship: part_of GO:0030132 ! clathrin coat of coated pit

[Term]
id: GO:0030123
name: AP-3 adaptor complex
namespace: cellular_component
def: "An adaptor complex found associated with endosomal membranes; it is not clear whether AP-3 forms clathrin coats in vivo." [GOC:mah, PMID:10611976]
is_a: GO:0030119 ! membrane coat adaptor complex

[Term]
id: GO:0030124
name: AP-4 adaptor complex
namespace: cellular_component
def: "An adaptor complex found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976]
is_a: GO:0030119 ! membrane coat adaptor complex

[Term]
id: GO:0030125
name: clathrin vesicle coat
namespace: cellular_component
def: "A clathrin coat found on a vesicle." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0030120 ! vesicle coat
relationship: part_of GO:0030665 ! clathrin coated vesicle membrane

[Term]
id: GO:0030126
name: COPI vesicle coat
namespace: cellular_component
alt_id: GO:0017167
def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]
exact_synonym: "coatomer" []
is_a: GO:0030120 ! vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0030663 ! COPI coated vesicle membrane

[Term]
id: GO:0030127
name: COPII vesicle coat
namespace: cellular_component
def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:mah, PMID:11252894]
is_a: GO:0030120 ! vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane

[Term]
id: GO:0030128
name: clathrin coat of endocytic vesicle
namespace: cellular_component
def: "A clathrin coat found on an endocytic vesicle." [GOC:mah]
exact_synonym: "clathrin coat of endocytotic vesicle" []
is_a: GO:0030125 ! clathrin vesicle coat
relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane

[Term]
id: GO:0030129
name: clathrin coat of synaptic vesicle
namespace: cellular_component
def: "A clathrin coat found on a synaptic vesicle." [GOC:mah]
is_a: GO:0030125 ! clathrin vesicle coat
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0030130
name: clathrin coat of trans-Golgi network vesicle
namespace: cellular_component
def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
exact_synonym: "clathrin coat of TGN vesicle" []
is_a: GO:0030125 ! clathrin vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane

[Term]
id: GO:0030131
name: clathrin adaptor complex
namespace: cellular_component
def: "A membrane adaptor complex that links clathrin to a membrane." [GOC:mah]
is_a: GO:0030119 ! membrane coat adaptor complex
relationship: part_of GO:0030118 ! clathrin coat

[Term]
id: GO:0030132
name: clathrin coat of coated pit
namespace: cellular_component
def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005905 ! coated pit

[Term]
id: GO:0030133
name: transport vesicle
namespace: cellular_component
def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, and to destinations within or outside the cell." [GOC:mah]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
narrow_synonym: "Golgi to plasma membrane transport vesicle" []
narrow_synonym: "Golgi to vacuole transport vesicle" []
narrow_synonym: "Golgi-plasma membrane transport vesicle" []
narrow_synonym: "Golgi-vacuole transport vesicle" []
broad_synonym: "secretory vesicle" []
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0030134
name: ER to Golgi transport vesicle
namespace: cellular_component
alt_id: GO:0030138
def: "A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport." [GOC:mah, PMID:11252894]
related_synonym: "COPII vesicle" []
exact_synonym: "COPII-coated vesicle" []
exact_synonym: "endoplasmic reticulum to Golgi transport vesicle" []
exact_synonym: "endoplasmic reticulum-Golgi transport vesicle" []
exact_synonym: "ER-Golgi transport vesicle" []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030135
name: coated vesicle
namespace: cellular_component
def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0030136
name: clathrin-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030137
name: COPI-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894]
related_synonym: "coatomer" []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030139
name: endocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]
exact_synonym: "endocytotic transport vesicle" []
exact_synonym: "endocytotic vesicle" []
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0030140
name: trans-Golgi network transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]
exact_synonym: "TGN transport vesicle" []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030141
name: secretory granule
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a single-layered membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
broad_synonym: "secretory vesicle" []
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0030142
name: Golgi to ER transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah]
exact_synonym: "Golgi to endoplasmic reticulum transport vesicle" []
exact_synonym: "Golgi-endoplasmic reticulum transport vesicle" []
exact_synonym: "Golgi-ER transport vesicle" []
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030143
name: inter-Golgi transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030173
name: integral to Golgi membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
exact_synonym: "Golgi integral membrane protein" []
is_a: GO:0031228 ! intrinsic to Golgi membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0030175
name: filopodium
namespace: cellular_component
alt_id: GO:0030028
def: "Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:mah, ISBN:0815316194]
exact_synonym: "microspike" []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0030176
name: integral to endoplasmic reticulum membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
exact_synonym: "ER integral membrane protein" []
exact_synonym: "integral to ER membrane" []
is_a: GO:0031227 ! intrinsic to endoplasmic reticulum membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0030232
name: insulin control element activator complex
namespace: cellular_component
def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390]
exact_synonym: "ICE activator complex" []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0030256
name: type I protein secretion system complex
namespace: cellular_component
def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0030257
name: type III protein secretion system complex
namespace: cellular_component
def: "A complex of approximately 20 proteins, most of which are located in the inner membrane that carries out protein secretion in the type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0030285
name: integral to synaptic vesicle membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
is_a: GO:0016021 ! integral to membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0030286
name: dynein complex
namespace: cellular_component
def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0030287
name: periplasmic space (sensu Fungi)
namespace: cellular_component
def: "The region between the plasma membrane and the cell wall. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mah, ISBN:0198547684]
broad_synonym: "periplasmic space" []
is_a: GO:0042597 ! periplasmic space

[Term]
id: GO:0030288
name: periplasmic space (sensu Proteobacteria)
namespace: cellular_component
def: "The region between the inner (cytoplasmic) membrane and outer membrane. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mlg]
subset: gosubset_prok
exact_synonym: "periplasmic space (sensu Gram-negative bacteria)" []
broad_synonym: "periplasm" []
broad_synonym: "periplasmic space" []
is_a: GO:0042597 ! periplasmic space
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0030289
name: protein phosphatase 4 complex
namespace: cellular_component
def: "The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit." [PMID:10026142]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:go_curators]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030313
name: cell envelope
namespace: cellular_component
def: "Everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl, http://pathmicro.med.sc.edu/fox/cell_envelope.htm]
subset: goslim_generic
subset: gosubset_prok
is_a: GO:0030312 ! external encapsulating structure
is_a: GO:0031975 ! envelope

[Term]
id: GO:0030314
name: junctional membrane complex
namespace: cellular_component
def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]
broad_synonym: "triad junction" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0030315
name: T-tubule
namespace: cellular_component
def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [ISBN:0815316194]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0030386
name: ferredoxin:thioredoxin reductase complex
namespace: cellular_component
def: "Complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0030424
name: axon
namespace: cellular_component
def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0030425
name: dendrite
namespace: cellular_component
def: "A branching protoplasmic process of a neuron that receive and integrate signals coming from axons of other neurons, and convey the resulting signal to the body of the cell." [GOC:nln, ISBN:0198506732]
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0030426
name: growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0030427
name: site of polarized growth
namespace: cellular_component
alt_id: GO:0000134
alt_id: GO:0030483
def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah]
subset: goslim_yeast
exact_synonym: "site of polarized growth (sensu Fungi)" []
exact_synonym: "site of polarized growth (sensu Saccharomyces)" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030428
name: cell septum
namespace: cellular_component
def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526]
subset: gosubset_prok
exact_synonym: "cross wall" []
broad_synonym: "septum" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030430
name: host cell cytoplasm
namespace: cellular_component
def: "The cytoplasm of a host cell." [GOC:mah]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0043656 ! intracellular region of host

[Term]
id: GO:0030445
name: yeast-form cell wall
namespace: cellular_component
def: "The cell wall surrounding a fungal cell in the single-cell, or yeast, form." [GOC:mah]
comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'.
is_a: GO:0009277 ! cell wall (sensu Fungi)

[Term]
id: GO:0030446
name: hyphal cell wall
namespace: cellular_component
def: "The cell wall surrounding a fungal hypha." [GOC:mah]
comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'.
is_a: GO:0009277 ! cell wall (sensu Fungi)

[Term]
id: GO:0030478
name: actin cap
namespace: cellular_component
alt_id: GO:0000143
def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell." [GOC:mah, ISBN:10652251]
exact_synonym: "actin cap (sensu Fungi)" []
narrow_synonym: "actin cap (sensu Saccharomyces)" []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030479
name: actin cortical patch
namespace: cellular_component
alt_id: GO:0005857
def: "Discrete actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mah, ISBN:0879693568, ISBN:0879693649, Sanger:wv]
exact_synonym: "actin cortical patch (sensu Fungi)" []
exact_synonym: "actin patch" []
narrow_synonym: "actin cortical patch (sensu Saccharomyces)" []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030482
name: actin cable
namespace: cellular_component
alt_id: GO:0000141
def: "A long bundle of actin filaments, comprising filamentous actin and associated proteins, found in cells." [ISBN:0879693649]
exact_synonym: "actin cable (sensu Fungi)" []
exact_synonym: "actin cable (sensu Saccharomyces)" []
is_a: GO:0032432 ! actin filament bundle

[Term]
id: GO:0030484
name: muscle fiber
namespace: cellular_component
def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194]
comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, use the cellular component term 'contractile fiber ; GO:0043292'.
exact_synonym: "muscle fibre" []
is_obsolete: true

[Term]
id: GO:0030485
name: smooth muscle contractile fiber
namespace: cellular_component
def: "The contractile fiber of smooth muscle cells." [GOC:mah]
exact_synonym: "smooth muscle fibre" []
broad_synonym: "smooth muscle fiber" []
is_a: GO:0043292 ! contractile fiber
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0030486
name: smooth muscle dense body
namespace: cellular_component
def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030485 ! smooth muscle contractile fiber

[Term]
id: GO:0030496
name: midbody
namespace: cellular_component
def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030526
name: granulocyte macrophage colony-stimulating factor receptor complex
namespace: cellular_component
def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0030529
name: ribonucleoprotein complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
subset: gosubset_prok
exact_synonym: "ribonucleoprotein" []
exact_synonym: "RNP" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030530
name: heterogeneous nuclear ribonucleoprotein complex
namespace: cellular_component
def: "Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732]
exact_synonym: "heterogeneous nuclear ribonucleoprotein" []
exact_synonym: "hnRNP" []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030531
name: small cytoplasmic ribonucleoprotein complex
namespace: cellular_component
def: "A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah]
exact_synonym: "scRNP" []
exact_synonym: "small cytoplasmic ribonucleoprotein" []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030532
name: small nuclear ribonucleoprotein complex
namespace: cellular_component
def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
exact_synonym: "small nuclear ribonucleoprotein" []
exact_synonym: "snRNP" []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030615
name: spindle pole
namespace: cellular_component
def: "OBSOLETE. One of the pair of centrosomes in a cell undergoing mitosis. Microtubules radiating from these centrosomes form the mitotic spindle." [http://www.cytokinetics.com]
comment: This term was made obsolete because the original definition was too narrow. To update annotations, use the cellular component term 'spindle pole ; GO:0000922'.
is_obsolete: true

[Term]
id: GO:0030658
name: transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah]
broad_synonym: "secretory vesicle membrane" []
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030659 ! cytoplasmic vesicle membrane

[Term]
id: GO:0030659
name: cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
is_a: GO:0012506 ! vesicle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0030660
name: Golgi-associated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]
related_synonym: "Golgi vesicle membrane" []
is_a: GO:0000139 ! Golgi membrane
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0030661
name: chitosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chitosome." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0045009 ! chitosome

[Term]
id: GO:0030662
name: coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0030135 ! coated vesicle

[Term]
id: GO:0030663
name: COPI coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah]
is_a: GO:0030662 ! coated vesicle membrane
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030665
name: clathrin coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030666
name: endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0030139 ! endocytic vesicle

[Term]
id: GO:0030667
name: secretory granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a secretory granule." [GOC:mah]
broad_synonym: "secretory vesicle membrane" []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0030668
name: dense granule membrane (sensu Apicomplexa)
namespace: cellular_component
def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites. As in, but not restricted to, the apicomplexans (Apicomplexa, ncbi_taxonomy_id:5794)." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0020026 ! dense granule (sensu Apicomplexa)

[Term]
id: GO:0030669
name: clathrin-coated endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah]
is_a: GO:0030665 ! clathrin coated vesicle membrane
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle

[Term]
id: GO:0030670
name: phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah]
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0030671
name: clathrin-coated phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah]
is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle

[Term]
id: GO:0030672
name: synaptic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]
is_a: GO:0012506 ! vesicle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0030673
name: axolemma
namespace: cellular_component
def: "The plasma membrane of an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653]
is_a: GO:0016020 ! membrane
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0030677
name: ribonuclease P complex
namespace: cellular_component
def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]
comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA.
subset: gosubset_prok
exact_synonym: "RNase P complex" []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0030678
name: mitochondrial ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094]
exact_synonym: "mitochondrial RNase P complex" []
is_a: GO:0030677 ! ribonuclease P complex
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0030679
name: cyanelle ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
exact_synonym: "cyanelle RNase P complex" []
is_a: GO:0030681 ! multimeric ribonuclease P complex
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0030680
name: dimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule." [GOC:mah, PMID:12045094]
subset: gosubset_prok
exact_synonym: "dimeric RNase P complex" []
narrow_synonym: "ribonuclease P complex (sensu Bacteria)" []
narrow_synonym: "RNase P complex (sensu Bacteria)" []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030681
name: multimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules." [GOC:mah, PMID:11142368, PMID:12045094]
exact_synonym: "multimeric RNase P complex" []
narrow_synonym: "ribonuclease P complex (sensu Archaea" []
narrow_synonym: "RNase P complex (sensu Archaea)" []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030684
name: preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030685
name: nucleolar preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516]
is_a: GO:0030684 ! preribosome
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0030686
name: 90S preribosome
namespace: cellular_component
def: "A preribosomal complex consisting of the 35S pre-rRNA, the 5S rRNA, early-associating ribosomal proteins, and associated proteins." [PMID:10567516]
is_a: GO:0030685 ! nucleolar preribosome

[Term]
id: GO:0030687
name: nucleolar preribosome, large subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 66S in Saccharomyces.
narrow_synonym: "66S preribosome" []
is_a: GO:0030685 ! nucleolar preribosome

[Term]
id: GO:0030688
name: nucleolar preribosome, small subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 43S in Saccharomyces.
narrow_synonym: "43S preribosome" []
is_a: GO:0030685 ! nucleolar preribosome

[Term]
id: GO:0030689
name: Noc complex
namespace: cellular_component
def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671]
comment: Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found.
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030690
name: Noc1p-Noc2p complex
namespace: cellular_component
def: "A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030687 ! nucleolar preribosome, large subunit precursor

[Term]
id: GO:0030691
name: Noc2p-Noc3p complex
namespace: cellular_component
def: "A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030687 ! nucleolar preribosome, large subunit precursor

[Term]
id: GO:0030692
name: Noc4p-Nop14p complex
namespace: cellular_component
def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030688 ! nucleolar preribosome, small subunit precursor

[Term]
id: GO:0030694
name: flagellar basal body, rod (sensu Bacteria)
namespace: cellular_component
def: "The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
is_a: GO:0044461 ! flagellar part (sensu Bacteria)
relationship: part_of GO:0009425 ! flagellar basal body (sensu Bacteria)

[Term]
id: GO:0030700
name: glycine reductase complex
namespace: cellular_component
def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030849
name: autosome
namespace: cellular_component
def: "Any chromosome other than a sex chromosome." [GOC:mah]
comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism.
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0030863
name: cortical cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0030864
name: cortical actin cytoskeleton
namespace: cellular_component
def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0030867
name: rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah]
exact_synonym: "rough ER membrane" []
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0030868
name: smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah]
exact_synonym: "smooth ER membrane" []
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0030869
name: RENT complex
namespace: cellular_component
def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389]
is_a: GO:0005677 ! chromatin silencing complex

[Term]
id: GO:0030870
name: Mre11 complex
namespace: cellular_component
def: "Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [GOC:mah, PMID:11988766]
exact_synonym: "MRN complex" []
exact_synonym: "MRX complex" []
exact_synonym: "Rad50 complex" []
exact_synonym: "Rad50-Rad32-Nbs1 complex" []
exact_synonym: "RMX complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030871
name: cytosolic ribosome (sensu Archaea)
namespace: cellular_component
def: "The ribosome of an archaeal cell; the archael ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit. As in, but not restricted to, the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [GOC:mlg]
is_a: GO:0005840 ! ribosome

[Term]
id: GO:0030872
name: cytosolic large ribosomal subunit (sensu Archaea)
namespace: cellular_component
def: "The large subunit of an archaeal ribosome; has a sedimentation coefficient of 50S. As in, but not restricted to, the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [GOC:mlg]
is_a: GO:0015934 ! large ribosomal subunit
relationship: part_of GO:0030871 ! cytosolic ribosome (sensu Archaea)

[Term]
id: GO:0030873
name: cytosolic small ribosomal subunit (sensu Archaea)
namespace: cellular_component
def: "The small subunit of an archaeal ribosome; has a sedimentation coefficient of 30S. As in, but not restricted to, the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [GOC:mlg]
is_a: GO:0015935 ! small ribosomal subunit
relationship: part_of GO:0030871 ! cytosolic ribosome (sensu Archaea)

[Term]
id: GO:0030874
name: nucleolar chromatin
namespace: cellular_component
def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah]
is_a: GO:0044452 ! nucleolar part
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0030875
name: rDNA protrusion
namespace: cellular_component
def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244]
comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern.
exact_synonym: "ribosomal DNA protrusion" []
is_a: GO:0044452 ! nucleolar part
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0030874 ! nucleolar chromatin

[Term]
id: GO:0030876
name: interleukin-20 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-20; comprises an alpha and a beta subunit." [GOC:mah]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0030877
name: beta-catenin destruction complex
namespace: cellular_component
def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]
exact_synonym: "beta-catenin degradation complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030880
name: RNA polymerase complex
namespace: cellular_component
def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030891
name: VCB complex
namespace: cellular_component
def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071]
exact_synonym: "pVHL-elongin C-elongin B complex" []
exact_synonym: "VHL complex" []
exact_synonym: "von Hippel-Lindau tumor suppressor complex" []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex

[Term]
id: GO:0030892
name: mitotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522]
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030893
name: meiotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522]
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030894
name: replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0030895
name: apolipoprotein B mRNA editing enzyme complex
namespace: cellular_component
def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591]
exact_synonym: "apoB mRNA editing enzyme complex" []
exact_synonym: "APOBEC" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030896
name: checkpoint clamp complex
namespace: cellular_component
def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]
comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p.
exact_synonym: "CCC" []
exact_synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0030897
name: HOPS complex
namespace: cellular_component
def: "A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:10944212]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0030904
name: retromer complex
namespace: cellular_component
def: "A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700147]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030905
name: retromer complex, outer shell
namespace: cellular_component
def: "One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer." [PMID:9700147]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030906
name: retromer complex, inner shell
namespace: cellular_component
def: "One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p." [PMID:9700147]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030907
name: MBF transcription complex
namespace: cellular_component
def: "A complex of two or three proteins that binds to the Mlu1 cell cycle box (MCB) promoter element and is involved in cell cycle-dependent regulation of transcription. In Saccharomyces the complex consists of Mbp1p and Swi6p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [PMID:9343385]
exact_synonym: "DSC1 transcription factor complex" []
exact_synonym: "MBF" []
exact_synonym: "Mlu1-box binding factor" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0005667 ! transcription factor complex

[Term]
id: GO:0030914
name: STAGA complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0030915
name: Smc5-Smc6 complex
namespace: cellular_component
def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5 and Smc6, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S.cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0030929
name: ADPG pyrophosphorylase complex
namespace: cellular_component
def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030930
name: ADPG pyrophosphorylase complex (sensu Bacteria)
namespace: cellular_component
def: "A homotetrameric that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030931
name: ADPG pyrophosphorylase complex (sensu Eukaryota)
namespace: cellular_component
def: "A heterotetrameric that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030932
name: amyloplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0030933
name: chloroplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0030934
name: anchoring collagen
namespace: cellular_component
def: "Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976]
exact_synonym: "connecting collagen" [ISBN:0721639976]
exact_synonym: "linking collagen" [ISBN:0721639976]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0030935
name: sheet-forming collagen
namespace: cellular_component
def: "Any collagen polymer in which collagen triple helices associate to form sheet-like networks." [ISBN:0721639976]
exact_synonym: "network-forming collagen" [ISBN:0815316194]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0030936
name: transmembrane collagen
namespace: cellular_component
def: "Any collagen polymer that passes through a lipid bilayer membrane." [ISBN:0721639976]
exact_synonym: "MACIT" [ISBN:0198599587]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0030937
name: collagen type XVII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina." [ISBN:0721639976]
is_a: GO:0030936 ! transmembrane collagen

[Term]
id: GO:0030938
name: collagen type XVIII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0030956
name: glutamyl-tRNA(Gln) amidotransferase complex
namespace: cellular_component
def: "Complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutamyl-tRNA(Gln) amidotransferase activity ; GO:0017068'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030958
name: RITS complex
namespace: cellular_component
def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433]
is_a: GO:0031332 ! RNAi effector complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0005720 ! nuclear heterochromatin

[Term]
id: GO:0030964
name: NADH dehydrogenase complex (quinone)
namespace: cellular_component
def: "Complex that possesses NADH dehydrogenase (quinone) activity." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0030966
name: NADH dehydrogenase complex (quinone) (sensu Bacteria)
namespace: cellular_component
def: "Complex that possesses NADH dehydrogenase (quinone) activity, as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030964 ! NADH dehydrogenase complex (quinone)
is_a: GO:0044424 ! intracellular part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0045272 ! respiratory chain complex I (sensu Bacteria)

[Term]
id: GO:0030981
name: cortical microtubule cytoskeleton
namespace: cellular_component
def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton

[Term]
id: GO:0030988
name: high molecular weight kininogen receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0030990
name: intraflagellar transport particle
namespace: cellular_component
def: "A nonmembrane-bound oliogmeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:kva, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0030991
name: intraflagellar transport particle A
namespace: cellular_component
def: "The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:kva, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0030990 ! intraflagellar transport particle

[Term]
id: GO:0030992
name: intraflagellar transport particle B
namespace: cellular_component
def: "The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:kva, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0030990 ! intraflagellar transport particle

[Term]
id: GO:0030993
name: axonemal heterotrimeric kinesin-II complex
namespace: cellular_component
def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kva, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0030998
name: linear element
namespace: cellular_component
def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [Sanger:jb "Jurg Bahler"]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0031002
name: actin rod
namespace: cellular_component
def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum." [GOC:kp]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0031003
name: actin tubule
namespace: cellular_component
def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0031002 ! actin rod

[Term]
id: GO:0031004
name: potassium ion-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497]
exact_synonym: "Kdp system complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031009
name: plastid ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah]
is_a: GO:0030931 ! ADPG pyrophosphorylase complex (sensu Eukaryota)
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0031010
name: ISWI complex
namespace: cellular_component
def: "Any chromatin remodeling complex that contains an ATPase subunit of the ISWI family." [GOC:mah, PMID:15020051]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0031011
name: INO80 complex
namespace: cellular_component
def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0031012
name: extracellular matrix
namespace: cellular_component
def: "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0031015
name: karyopherin docking complex
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357]
narrow_synonym: "Asm4p-containing complex" []
broad_synonym: "nuclear pore subcomplex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0031019
name: mitochondrial mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607]
exact_synonym: "mitochondrial editosome" []
is_a: GO:0045293 ! mRNA editing complex

[Term]
id: GO:0031020
name: plastid mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in a plastid." [GOC:mah]
exact_synonym: "plastid editosome" []
is_a: GO:0045293 ! mRNA editing complex

[Term]
id: GO:0031021
name: interphase microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790]
exact_synonym: "iMTOC" []
exact_synonym: "interphase microtubule organising center" []
exact_synonym: "interphase MTOC" []
is_a: GO:0005815 ! microtubule organizing center

[Term]
id: GO:0031026
name: glutamate synthase complex
namespace: cellular_component
def: "A complex that possesses glutamate synthase activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031027
name: glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0031039
name: macronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [TGD:ns]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031040
name: micronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [TGD:ns]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031045
name: dense core granule
namespace: cellular_component
def: "Electron-dense organelle found in ciliates, with a granular internal matrix; contains proteins destined to be secreted." [PMID:14690495]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031074
name: nucleocytoplasmic shuttling complex
namespace: cellular_component
def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031080
name: Nup107-160 complex
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p." [PMID:10747086, PMID:11823431, PMID:15226438]
exact_synonym: "Nup107-120 complex" []
exact_synonym: "Nup84 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0031082
name: BLOC complex
namespace: cellular_component
def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031083
name: BLOC-1 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complx contains the Pallidin, Muted, Cappuccino, Dysbindin, Sapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031084
name: BLOC-2 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031085
name: BLOC-3 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031088
name: platelet dense granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031089
name: platelet dense granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031090
name: organelle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an organelle." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016020 ! membrane
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0043227 ! membrane-bound organelle

[Term]
id: GO:0031091
name: platelet alpha granule
namespace: cellular_component
def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233]
exact_synonym: "platelet alpha-granule" []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031092
name: platelet alpha granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233]
exact_synonym: "platelet alpha-granule membrane" []
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031093
name: platelet alpha granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233]
exact_synonym: "platelet alpha-granule lumen" []
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031094
name: platelet dense tubular network
namespace: cellular_component
def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202]
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0031095
name: platelet dense tubular network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031096
name: platelet dense tubular network lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031097
name: medial ring
namespace: cellular_component
def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning." [GOC:vw, PMID:15572668]
related_synonym: "medial cortex" []
is_a: GO:0032155 ! cell division site part
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0031105
name: septin complex
namespace: cellular_component
def: "Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0031143
name: pseudopodium
namespace: cellular_component
def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732]
exact_synonym: "pseudopod" []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0031160
name: spore wall
namespace: cellular_component
def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]
exact_synonym: "spore coat" []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0031164
name: contractile vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000331 ! contractile vacuole

[Term]
id: GO:0031165
name: integral to contractile vacuolar membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:pg]
is_a: GO:0031166 ! integral to vacuolar membrane
is_a: GO:0031311 ! intrinsic to contractile vacuolar membrane

[Term]
id: GO:0031166
name: integral to vacuolar membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031310 ! intrinsic to vacuolar membrane

[Term]
id: GO:0031201
name: SNARE complex
namespace: cellular_component
def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [PMID:10872468]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0031205
name: Sec complex (sensu Eukaryota)
namespace: cellular_component
def: "A membrane associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [PMID:12158317, PMID:14617809]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0031206
name: Sec complex-associated translocon complex
namespace: cellular_component
def: "A translocon complex physically associated with a Sec complex." [GOC:mah, PMID:12518317, PMID:14617809]
is_a: GO:0005784 ! translocon complex
relationship: part_of GO:0031205 ! Sec complex (sensu Eukaryota)

[Term]
id: GO:0031207
name: Sec62/Sec63 complex
namespace: cellular_component
def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809]
exact_synonym: "ER protein translocation subcomplex " []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031205 ! Sec complex (sensu Eukaryota)

[Term]
id: GO:0031209
name: SCAR complex
namespace: cellular_component
def: "A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
exact_synonym: "WAVE complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031211
name: palmitoyltransferase complex
namespace: cellular_component
def: "A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031213
name: RSF complex
namespace: cellular_component
def: "A chromatin remodeling complex that mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In humans, the complex is composed of the ATPase hSNF2H and the HBXAP protein (RSF-1)." [PMID:12972596]
exact_synonym: "remodeling and spacing factor complex " []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0031224
name: intrinsic to membrane
namespace: cellular_component
def: "Located in a membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.
subset: gosubset_prok
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0031225
name: anchored to membrane
namespace: cellular_component
def: "Tethered to a membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane." [GOC:mah]
is_a: GO:0031224 ! intrinsic to membrane

[Term]
id: GO:0031226
name: intrinsic to plasma membrane
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031224 ! intrinsic to membrane
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031227
name: intrinsic to endoplasmic reticulum membrane
namespace: cellular_component
def: "Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031228
name: intrinsic to Golgi membrane
namespace: cellular_component
def: "Located in the Golgi membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0031229
name: intrinsic to nuclear inner membrane
namespace: cellular_component
def: "Located in the nuclear inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005637 ! nuclear inner membrane

[Term]
id: GO:0031230
name: intrinsic to outer membrane (sensu Proteobacteria)
namespace: cellular_component
def: "Located in the outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
subset: gosubset_prok
exact_synonym: "intrinsic to outer membrane (sensu Gram-negative bacteria)" []
is_a: GO:0031224 ! intrinsic to membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! outer membrane (sensu Proteobacteria)

[Term]
id: GO:0031231
name: intrinsic to peroxisomal membrane
namespace: cellular_component
def: "Located in the peroxisomal membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044439 ! peroxisomal part
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0031232
name: extrinsic to external side of plasma membrane
namespace: cellular_component
def: "Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0019897 ! extrinsic to plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031233
name: intrinsic to external side of plasma membrane
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm." [GOC:mah]
is_a: GO:0031226 ! intrinsic to plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031234
name: extrinsic to internal side of plasma membrane
namespace: cellular_component
def: "Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0009898 ! internal side of plasma membrane

[Term]
id: GO:0031235
name: intrinsic to internal side of plasma membrane
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm." [GOC:mah]
is_a: GO:0031226 ! intrinsic to plasma membrane
relationship: part_of GO:0009898 ! internal side of plasma membrane

[Term]
id: GO:0031236
name: extrinsic to external side of plasma membrane, in periplasmic space
namespace: cellular_component
def: "Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031232 ! extrinsic to external side of plasma membrane
relationship: part_of GO:0042597 ! periplasmic space

[Term]
id: GO:0031237
name: intrinsic to external side of plasma membrane, in periplasmic space
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space." [GOC:mah]
is_a: GO:0031233 ! intrinsic to external side of plasma membrane
relationship: part_of GO:0042597 ! periplasmic space

[Term]
id: GO:0031238
name: extrinsic to external side of plasma membrane, in periplasmic space (sensu Proteobacteria)
namespace: cellular_component
def: "Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
exact_synonym: "extrinsic to external side of plasma membrane, in periplasmic space (sensu Gram-negative bacteria)" []
is_a: GO:0031236 ! extrinsic to external side of plasma membrane, in periplasmic space
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030288 ! periplasmic space (sensu Proteobacteria)

[Term]
id: GO:0031239
name: intrinsic to external side of plasma membrane, in periplasmic space (sensu Proteobacteria)
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
exact_synonym: "intrinsic to external side of plasma membrane, in periplasmic space (sensu Gram-negative bacteria)" []
is_a: GO:0031237 ! intrinsic to external side of plasma membrane, in periplasmic space
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030288 ! periplasmic space (sensu Proteobacteria)

[Term]
id: GO:0031240
name: external side of outer membrane
namespace: cellular_component
def: "The side of the outer membrane that is opposite to the side that faces the periplasm." [GOC:mlg]
is_a: GO:0044425 ! membrane part
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! outer membrane (sensu Proteobacteria)

[Term]
id: GO:0031241
name: internal side of outer membrane
namespace: cellular_component
def: "The side of the outer membrane that faces the periplasm." [GOC:mlg]
is_a: GO:0044425 ! membrane part
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! outer membrane (sensu Proteobacteria)

[Term]
id: GO:0031242
name: extrinsic to external side of outer membrane
namespace: cellular_component
def: "Loosely bound to the surface of the outer membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031244 ! extrinsic to outer membrane (sensu Proteobacteria)
relationship: part_of GO:0031240 ! external side of outer membrane

[Term]
id: GO:0031243
name: intrinsic to external side of outer membrane
namespace: cellular_component
def: "Located in the outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the periplasm." [GOC:mah]
is_a: GO:0031230 ! intrinsic to outer membrane (sensu Proteobacteria)
relationship: part_of GO:0031240 ! external side of outer membrane

[Term]
id: GO:0031244
name: extrinsic to outer membrane (sensu Proteobacteria)
namespace: cellular_component
def: "Loosely bound to one surface of the outer membrane, but not integrated into the hydrophobic region. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
exact_synonym: "extrinsic to outer membrane (sensu Gram-negative bacteria)" []
is_a: GO:0019898 ! extrinsic to membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! outer membrane (sensu Proteobacteria)

[Term]
id: GO:0031245
name: extrinsic to internal side of outer membrane
namespace: cellular_component
def: "Loosely bound to the surface of the outer membrane that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031244 ! extrinsic to outer membrane (sensu Proteobacteria)
relationship: part_of GO:0031241 ! internal side of outer membrane

[Term]
id: GO:0031246
name: intrinsic to internal side of outer membrane
namespace: cellular_component
def: "Located in the outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the periplasm." [GOC:mah]
is_a: GO:0031230 ! intrinsic to outer membrane (sensu Proteobacteria)
relationship: part_of GO:0031241 ! internal side of outer membrane

[Term]
id: GO:0031248
name: protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyses the transfer of an acetyl group to a protein acceptor molecule." [UniProtKB:bf]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031250
name: anaerobic ribonucleoside-triphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031251
name: PAN complex
namespace: cellular_component
def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]
exact_synonym: "poly(A) nuclease complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031252
name: leading edge
namespace: cellular_component
def: "The area of a motile cell closest to the direction of movement." [GOC:pg]
exact_synonym: "front of cell" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031253
name: cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cell surface projection." [GOC:mah]
related_synonym: "membrane extension" []
related_synonym: "membrane projection" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0044463 ! cell projection part

[Term]
id: GO:0031254
name: trailing edge
namespace: cellular_component
def: "The area of a motile cell opposite to the direction of movement." [GOC:pg]
exact_synonym: "back of cell" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031255
name: lateral part of motile cell
namespace: cellular_component
def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031256
name: leading edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031252 ! leading edge

[Term]
id: GO:0031257
name: trailing edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031254 ! trailing edge

[Term]
id: GO:0031258
name: lamellipodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0030027 ! lamellipodium

[Term]
id: GO:0031259
name: uropod membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031257 ! trailing edge membrane
relationship: part_of GO:0001931 ! uropod

[Term]
id: GO:0031260
name: pseudopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0031143 ! pseudopodium

[Term]
id: GO:0031261
name: DNA replication preinitiation complex
namespace: cellular_component
def: "A multiprotein complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dbp11p, DNA polymerases, and others." [PMID:12694535, PMID:15194812]
exact_synonym: "pre-IC" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0031262
name: Ndc80 complex
namespace: cellular_component
def: "A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore." [PMID:15509863, PMID:15661517]
exact_synonym: "Nuf2-Ndc80 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0031264
name: death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
exact_synonym: "death-inducing signalling complex" []
exact_synonym: "DISC" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031265
name: CD95 death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
exact_synonym: "CD95 death-inducing signalling complex" []
exact_synonym: "CD95 DISC" []
exact_synonym: "Fas death-inducing signaling complex" []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031266
name: TRAIL death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
exact_synonym: "TRAIL death-inducing signalling complex" []
exact_synonym: "TRAIL DISC" []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031298
name: replication fork protection complex
namespace: cellular_component
def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656]
narrow_synonym: "Swi1-Swi3 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043596 ! replication fork (sensu Eukaryota)

[Term]
id: GO:0031300
name: intrinsic to organelle membrane
namespace: cellular_component
def: "Located in an organelle membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031224 ! intrinsic to membrane
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0031301
name: integral to organelle membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0016021 ! integral to membrane
is_a: GO:0031300 ! intrinsic to organelle membrane

[Term]
id: GO:0031302
name: intrinsic to endosome membrane
namespace: cellular_component
def: "Located in the endosome membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031303
name: integral to endosome membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031302 ! intrinsic to endosome membrane

[Term]
id: GO:0031304
name: intrinsic to mitochondrial inner membrane
namespace: cellular_component
def: "Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031305
name: integral to mitochondrial inner membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031304 ! intrinsic to mitochondrial inner membrane

[Term]
id: GO:0031306
name: intrinsic to mitochondrial outer membrane
namespace: cellular_component
def: "Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0031307
name: integral to mitochondrial outer membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031306 ! intrinsic to mitochondrial outer membrane

[Term]
id: GO:0031308
name: intrinsic to nuclear outer membrane
namespace: cellular_component
def: "Located in the nuclear outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031309
name: integral to nuclear outer membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031308 ! intrinsic to nuclear outer membrane

[Term]
id: GO:0031310
name: intrinsic to vacuolar membrane
namespace: cellular_component
def: "Located in the vacuolar membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0031311
name: intrinsic to contractile vacuolar membrane
namespace: cellular_component
def: "Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031310 ! intrinsic to vacuolar membrane
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031312
name: extrinsic to organelle membrane
namespace: cellular_component
def: "Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0019898 ! extrinsic to membrane
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0031313
name: extrinsic to endosome membrane
namespace: cellular_component
def: "Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031314
name: extrinsic to mitochondrial inner membrane
namespace: cellular_component
def: "Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031315
name: extrinsic to mitochondrial outer membrane
namespace: cellular_component
def: "Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0031316
name: extrinsic to nuclear outer membrane
namespace: cellular_component
def: "Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031317
name: tripartite ATP-independent periplasmic transporter complex
namespace: cellular_component
def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using enery from ion gradients." [GOC:mlg]
exact_synonym: "TRAP transporter complex" []
exact_synonym: "TRAP-T transporter complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031332
name: RNAi effector complex
namespace: cellular_component
def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031350
name: intrinsic to plastid membrane
namespace: cellular_component
def: "Located in a plastid membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0042170 ! plastid membrane

[Term]
id: GO:0031351
name: integral to plastid membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0042170 ! plastid membrane

[Term]
id: GO:0031352
name: intrinsic to plastid inner membrane
namespace: cellular_component
def: "Located in a plastid inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031350 ! intrinsic to plastid membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0031353
name: integral to plastid inner membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031351 ! integral to plastid membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0031354
name: intrinsic to plastid outer membrane
namespace: cellular_component
def: "Located in a plastid outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031350 ! intrinsic to plastid membrane
relationship: part_of GO:0009527 ! plastid outer membrane

[Term]
id: GO:0031355
name: integral to plastid outer membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031351 ! integral to plastid membrane
relationship: part_of GO:0009527 ! plastid outer membrane

[Term]
id: GO:0031356
name: intrinsic to chloroplast inner membrane
namespace: cellular_component
def: "Located in the chloroplast inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031352 ! intrinsic to plastid inner membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031357
name: integral to chloroplast inner membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031353 ! integral to plastid inner membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031358
name: intrinsic to chloroplast outer membrane
namespace: cellular_component
def: "Located in the chloroplast outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031354 ! intrinsic to plastid outer membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0031359
name: integral to chloroplast outer membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031355 ! integral to plastid outer membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0031360
name: intrinsic to thylakoid membrane
namespace: cellular_component
def: "Located in a thylakoid membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0031361
name: integral to thylakoid membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0031362
name: anchored to external side of plasma membrane
namespace: cellular_component
def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah]
is_a: GO:0031233 ! intrinsic to external side of plasma membrane
is_a: GO:0046658 ! anchored to plasma membrane

[Term]
id: GO:0031371
name: ubiquitin conjugating enzyme complex
namespace: cellular_component
def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah]
related_synonym: "E2 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031372
name: UBC13-MMS2 complex
namespace: cellular_component
def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086]
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex

[Term]
id: GO:0031373
name: cytosolic fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex located in the cytosol." [GOC:mah]
is_a: GO:0005835 ! fatty acid synthase complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031374
name: cytosolic type I fatty acid synthase complex
namespace: cellular_component
def: "A cytosolic fatty acid synthase complex in which each polypeptide chain contains several different catalytic sites." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
is_a: GO:0031373 ! cytosolic fatty acid synthase complex

[Term]
id: GO:0031375
name: type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
is_a: GO:0005835 ! fatty acid synthase complex

[Term]
id: GO:0031376
name: cytosolic type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
is_a: GO:0031373 ! cytosolic fatty acid synthase complex
is_a: GO:0031375 ! type II fatty acid synthase complex

[Term]
id: GO:0031377
name: mitochondrial type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
is_a: GO:0031375 ! type II fatty acid synthase complex
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0031378
name: plastid type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
is_a: GO:0031375 ! type II fatty acid synthase complex
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0031379
name: RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0031380
name: nuclear RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]
exact_synonym: "RDRC" []
narrow_synonym: "Rdr1 complex" []
is_a: GO:0031379 ! RNA-directed RNA polymerase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031381
name: viral RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301]
is_a: GO:0031379 ! RNA-directed RNA polymerase complex

[Term]
id: GO:0031387
name: MPF complex
namespace: cellular_component
def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13p. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0031389
name: Rad17 RFC-like complex
namespace: cellular_component
def: "A pentameric complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Saccharomyces the subunits are known as Rad17p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842]
exact_synonym: "Rad17-RFC" []
exact_synonym: "Rad17-RLC" []
exact_synonym: "RFC (Rad17)" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031390
name: Ctf18 RFC-like complex
namespace: cellular_component
def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842]
exact_synonym: "Ctf18-RFC" []
exact_synonym: "Ctf18-RLC" []
exact_synonym: "RFC (Ctf18)" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031391
name: Elg1 RFC-like complex
namespace: cellular_component
def: "A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842]
exact_synonym: "Elg1-RFC" []
exact_synonym: "Elg1-RLC" []
exact_synonym: "RFC (Elg1)" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031395
name: bursicon neuropeptide hormone complex
namespace: cellular_component
def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [FB:rc]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0031410
name: cytoplasmic vesicle
namespace: cellular_component
def: "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031982 ! vesicle
is_a: GO:0043229 ! intracellular organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031411
name: gas vesicle
namespace: cellular_component
def: "A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations." [PMID:8177173]
subset: gosubset_prok
is_a: GO:0031410 ! cytoplasmic vesicle
is_a: GO:0043232 ! intracellular non-membrane-bound organelle

[Term]
id: GO:0031414
name: N-terminal protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah]
exact_synonym: "NAT complex" []
is_a: GO:0031248 ! protein acetyltransferase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031415
name: NatA complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471]
exact_synonym: "N-terminal acetyltransferase A complex" []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031416
name: NatB complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]
exact_synonym: "N-terminal acetyltransferase B complex" []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031417
name: NatC complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]
exact_synonym: "N-terminal acetyltransferase C complex" []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031421
name: invertasome
namespace: cellular_component
def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031422
name: RecQ helicase-Topo III complex
namespace: cellular_component
def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139]
narrow_synonym: "Sgs1-Top3 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031428
name: box C/D snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type." [ISBN:0879695897]
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex

[Term]
id: GO:0031429
name: box H/ACA snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type." [ISBN:0879695897]
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex

[Term]
id: GO:0031430
name: M line
namespace: cellular_component
def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link adjacent thick filaments to each other." [ISBN:0198506732, ISBN:0815316194]
exact_synonym: "M disc" []
exact_synonym: "mesophragma" []
broad_synonym: "midline" []
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031673 ! H zone

[Term]
id: GO:0031431
name: Dbf4-dependent protein kinase complex
namespace: cellular_component
def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100]
exact_synonym: "DDK" []
narrow_synonym: "Cdc7-Dbf4 complex" []
narrow_synonym: "Hsk1-Dfp1 kinase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031436
name: BRCA1-BARD1 complex
namespace: cellular_component
def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0031461
name: cullin-RING ubiquitin ligase complex
namespace: cellular_component
def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]
exact_synonym: "CRL complex" []
exact_synonym: "cullin complex" []
exact_synonym: "cullin-RING ligase" []
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:0031462
name: Cul2-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
related_synonym: "SCF2 complex" []
exact_synonym: "CDL2 complex" []
exact_synonym: "CRL2 complex" []
exact_synonym: "cullin-RING ligase 2" []
narrow_synonym: "VBC complex" []
broad_synonym: "CBC complex" []
broad_synonym: "EC2S complex" []
broad_synonym: "ECS complex" []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031463
name: Cul3-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]
related_synonym: "SCF3 complex" []
exact_synonym: "BC3B complex" []
exact_synonym: "BCR3 complex" []
exact_synonym: "CDL3 complex" []
exact_synonym: "CRL3 complex" []
exact_synonym: "cullin-RING ligase 3" []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031464
name: Cul4A-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]
related_synonym: "SCF4 complex" []
exact_synonym: "CDL4 complex" []
exact_synonym: "CRL4 complex" []
exact_synonym: "cullin-RING ligase 4A" []
exact_synonym: "DCX complex" []
narrow_synonym: "VDC complex" []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031465
name: Cul4B-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063]
exact_synonym: "cullin-RING ligase 4B" []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031466
name: Cul5-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
related_synonym: "SCF5 complex" []
exact_synonym: "CDL5 complex" []
exact_synonym: "CRL5 complex" []
exact_synonym: "cullin-RING ligase 5" []
broad_synonym: "EC2S complex" []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031467
name: Cul7-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063]
exact_synonym: "CDL7 complex" []
exact_synonym: "CRL7 complex" []
exact_synonym: "cullin-RING ligase 7" []
exact_synonym: "SCF7 complex" []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031469
name: polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle

[Term]
id: GO:0031470
name: carboxysome
namespace: cellular_component
def: "An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708]
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031471
name: ethanolamine degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753]
exact_synonym: "ethanolamine metabolosome" []
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031472
name: propanediol degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031474
name: myosin IV complex
namespace: cellular_component
def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031475
name: myosin V complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localisation and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031476
name: myosin VI complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031477
name: myosin VII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031478
name: myosin VIII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031479
name: myosin IX complex
namespace: cellular_component
def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031480
name: myosin X complex
namespace: cellular_component
def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031481
name: myosin XI complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031482
name: myosin XII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031483
name: myosin XIII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031484
name: myosin XIV complex
namespace: cellular_component
def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031485
name: myosin XV complex
namespace: cellular_component
def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031486
name: myosin XVI complex
namespace: cellular_component
def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031487
name: myosin XVII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031488
name: myosin XVIII complex
namespace: cellular_component
def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031499
name: TRAMP complex
namespace: cellular_component
def: "A multiprotein complex, which in yeast consists of Trf4p, Air1p or Air2p and Mtr4p. This nuclear RNA surveillance and quality control complex is involved in the distributive polyadenylation of substrates that include: hypomodified and incorrectly folded tRNAs, snoRNA precursors and rRNA precursors. It is also required for the degradative activity of the nuclear exosome in vivo." [PMID:15828860, PMID:15935758]
exact_synonym: "Trf4 complex" []
exact_synonym: "Trf4 poly(A) polymerase complex" []
exact_synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031500
name: Tea1 cell-end complex
namespace: cellular_component
def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270]
is_a: GO:0005875 ! microtubule associated complex
relationship: part_of GO:0000133 ! polarisome

[Term]
id: GO:0031501
name: mannosyltransferase complex
namespace: cellular_component
def: "A complex that posseses mannosyltransferase activity." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031502
name: dolichyl-phosphate-mannose-protein mannosyltransferase complex
namespace: cellular_component
def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, PMID:15948957]
related_synonym: "PMT family mannosyltransferase complex" []
exact_synonym: "protein O-mannosyltransferase complex" []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031510
name: SUMO activating enzyme complex
namespace: cellular_component
def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841]
exact_synonym: "SAE" []
exact_synonym: "SUMO E1 activator enzyme complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0031511
name: Mis6-Sim4 complex
namespace: cellular_component
def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182]
exact_synonym: "Sim4 complex" []
narrow_synonym: "Mis6 centromere subcomplex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000939 ! inner kinetochore of condensed chromosome

[Term]
id: GO:0031512
name: motile primary cilium
namespace: cellular_component
def: "A specialized primary cilium that contains a 9 + 0 arrangement of microtubules, radial spokes, and a dynein apparatus, but no inner doublet microtubules. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface." [GOC:kva]
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031513
name: nonmotile primary cilium
namespace: cellular_component
def: "An immotile primary cilium that may be missing the central pair of microtubules, or the central pair of microtubules and outer dynein arms. Some primary cilia also have altered arrangements of outer microtubules (fewer than nine and/or not always present as doublets). Nonmotile primary cilia typically function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kna]
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031514
name: motile secondary cilium
namespace: cellular_component
def: "A cilium that consists of a 9 + 2 arrangement of microtubules, radial spokes, and a dynein apparatus. Motile cilia, found on cells that line the lumenal ducts of various tissues, beat with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface." [GOC:kva]
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031515
name: tRNA (m1A) methyltransferase complex
namespace: cellular_component
def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0031518
name: CBF3 complex
namespace: cellular_component
def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, pericentric region

[Term]
id: GO:0031519
name: PcG protein complex
namespace: cellular_component
def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]
exact_synonym: "Polycomb Group protein complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031520
name: plasma membrane of cell tip
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0031521
name: spitzenkorper
namespace: cellular_component
def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0001411 ! hyphal tip

[Term]
id: GO:0031522
name: Sec complex (sensu Bacteria)
namespace: cellular_component
def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type I, II, IV, or V secretion systems. Sec complex components include SecA,D,E,F,G,Y and YajC. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:15223057]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031523
name: Myb complex
namespace: cellular_component
def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
exact_synonym: "Myeloblastosis proto-oncogene protein complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031526
name: brush border membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005903 ! brush border

[Term]
id: GO:0031527
name: filopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0031528
name: microvillus membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005902 ! microvillus

[Term]
id: GO:0031533
name: mRNA capping enzyme complex
namespace: cellular_component
def: "A protein complex that possesses RNA (guanine-N7) methyltransferase activity and carries out mRNA capping. The fungal mRNA capping apparatus consists of three subunits, a RNA 5' triphosphatase RNA guanyl transferase and mRNA (guanine-N7) methyltransferase activities (Cet1p, Ceg1, and Abd1p in S. cerevisiae). In mammalian sytems Cet1 and Ceg1 are replaced by a bifunctional triphosphatase/guanyltransferase." [GOC:vw, PMID:10347220]
exact_synonym: "mRNA (guanine-N7) methyltransferase complex" []
exact_synonym: "mRNA cap methyltransferase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031560
name: bud neck polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0005935 ! bud neck

[Term]
id: GO:0031561
name: bud tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0005934 ! bud tip

[Term]
id: GO:0031562
name: hyphal tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0001411 ! hyphal tip

[Term]
id: GO:0031563
name: mating projection tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532]
is_a: GO:0000133 ! polarisome
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0043332 ! mating projection tip

[Term]
id: GO:0031588
name: AMP-activated protein kinase complex
namespace: cellular_component
def: "A protein complex that possesses AMP-dependent protein kinase activity." [GOC:mah]
exact_synonym: "5'-AMP-activated protein kinase complex" []
narrow_synonym: "Snf1 kinase complex" []
narrow_synonym: "Snf1 serine/threonine protein kinase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031592
name: centrosomal corona
namespace: cellular_component
def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah]
comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material.
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0031594
name: neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction." [GOC:nln]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0031595
name: nuclear proteasome complex
namespace: cellular_component
def: "A proteasome found in the nucleus of a cell." [GOC:mah]
is_a: GO:0000502 ! proteasome complex (sensu Eukaryota)
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031596
name: ER proteasome complex
namespace: cellular_component
def: "A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0000502 ! proteasome complex (sensu Eukaryota)
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0031597
name: cytosolic proteasome complex (sensu Eukaryota)
namespace: cellular_component
def: "A proteasome found in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0000502 ! proteasome complex (sensu Eukaryota)
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031598
name: nuclear proteasome regulatory particle
namespace: cellular_component
def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005838 ! proteasome regulatory particle (sensu Eukaryota)
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031599
name: ER proteasome regulatory particle
namespace: cellular_component
def: "The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0005838 ! proteasome regulatory particle (sensu Eukaryota)
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031596 ! ER proteasome complex

[Term]
id: GO:0031600
name: cytosolic proteasome regulatory particle (sensu Eukaryota)
namespace: cellular_component
def: "The regulatory subcomplex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0005838 ! proteasome regulatory particle (sensu Eukaryota)
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031597 ! cytosolic proteasome complex (sensu Eukaryota)

[Term]
id: GO:0031601
name: nuclear proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005839 ! proteasome core complex (sensu Eukaryota)
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031602
name: ER proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0005839 ! proteasome core complex (sensu Eukaryota)
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031596 ! ER proteasome complex

[Term]
id: GO:0031603
name: cytosolic proteasome core complex (sensu Eukaryota)
namespace: cellular_component
def: "The core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0005839 ! proteasome core complex (sensu Eukaryota)
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031597 ! cytosolic proteasome complex (sensu Eukaryota)

[Term]
id: GO:0031604
name: nuclear proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex (sensu Eukaryota)
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031605
name: ER proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex (sensu Eukaryota)
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031602 ! ER proteasome core complex

[Term]
id: GO:0031606
name: cytosolic proteasome core complex, alpha-subunit complex (sensu Eukaryota)
namespace: cellular_component
def: "The subunits forming the outer ring of the core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex (sensu Eukaryota)
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031603 ! cytosolic proteasome core complex (sensu Eukaryota)

[Term]
id: GO:0031607
name: nuclear proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex (sensu Eukaryota)
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031608
name: ER proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex (sensu Eukaryota)
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031602 ! ER proteasome core complex

[Term]
id: GO:0031609
name: cytosolic proteasome core complex, beta-subunit complex (sensu Eukaryota)
namespace: cellular_component
def: "The subunits forming the inner ring of the core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex (sensu Eukaryota)
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031603 ! cytosolic proteasome core complex (sensu Eukaryota)

[Term]
id: GO:0031610
name: nuclear proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex (sensu Eukaryota)
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031611
name: ER proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex (sensu Eukaryota)
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031599 ! ER proteasome regulatory particle

[Term]
id: GO:0031612
name: cytosolic proteasome regulatory particle, base subcomplex (sensu Eukaryota)
namespace: cellular_component
def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex (sensu Eukaryota)
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle (sensu Eukaryota)

[Term]
id: GO:0031613
name: nuclear proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex (sensu Eukaryota)
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031614
name: ER proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex (sensu Eukaryota)
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031599 ! ER proteasome regulatory particle

[Term]
id: GO:0031615
name: cytosolic proteasome regulatory particle, lid subcomplex (sensu Eukaryota)
namespace: cellular_component
def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex (sensu Eukaryota)
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle (sensu Eukaryota)

[Term]
id: GO:0031616
name: spindle pole centrosome
namespace: cellular_component
def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]
is_a: GO:0005813 ! centrosome
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0031617
name: NMS complex
namespace: cellular_component
def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914]
exact_synonym: "Ndc80-MIND-Spc7 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0031618
name: nuclear centric heterochromatin
namespace: cellular_component
def: "Chromatin located near the centromere of a chromosome in the nucleus." [GOC:mah]
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:0005721 ! centric heterochromatin

[Term]
id: GO:0031633
name: xanthophore
namespace: cellular_component
def: "A chromatophore containing yellow pigment." [ISBN:0395825172]
comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells.
is_a: GO:0042716 ! chromatophore

[Term]
id: GO:0031672
name: A band
namespace: cellular_component
def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131]
exact_synonym: "A disc" []
exact_synonym: "anisotropic disc" []
exact_synonym: "Q disc" []
exact_synonym: "transverse disc" []
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031673
name: H zone
namespace: cellular_component
def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [ISBN:0321204131]
exact_synonym: "H band" []
exact_synonym: "H disc" []
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0031674
name: I band
namespace: cellular_component
def: "A region of a sarcomere that appears as a light band on each side of the Z line, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131]
exact_synonym: "I disc" []
exact_synonym: "isotropic disc" []
exact_synonym: "J disc" []
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031675
name: NADH dehydrogenase complex (plastoquinone)
namespace: cellular_component
alt_id: GO:0030025
def: "Complex that possesses NADH dehydrogenase (plastoquinone) activity." [GOC:mah]
exact_synonym: "NADH:plastoquinone reductase complex" []
is_a: GO:0030964 ! NADH dehydrogenase complex (quinone)
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0031676
name: thylakoid membrane (sensu Cyanobacteria)
namespace: cellular_component
def: "The pigmented membrane of a thylakoid. As in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117)." [GOC:mah]
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030075 ! thylakoid (sensu Cyanobacteria)

[Term]
id: GO:0031677
name: plastid NADH dehydrogenase complex (plastoquinone)
namespace: cellular_component
def: "A NADH dehydrogenase complex (plastoquinone) complex found in a plastid." [GOC:mah]
is_a: GO:0031675 ! NADH dehydrogenase complex (plastoquinone)
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009535 ! thylakoid membrane (sensu Viridiplantae)

[Term]
id: GO:0031678
name: NADH dehydrogenase complex (plastoquinone) (sensu Cyanobacteria)
namespace: cellular_component
def: "Complex that possesses NADH dehydrogenase (plastoquinone) activity, as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117)." [GOC:mah]
is_a: GO:0031675 ! NADH dehydrogenase complex (plastoquinone)
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031676 ! thylakoid membrane (sensu Cyanobacteria)

[Term]
id: GO:0031680
name: G-protein beta/gamma-subunit complex
namespace: cellular_component
def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
exact_synonym: "G-beta/G-gamma complex" []
narrow_synonym: "heterotrimeric G-protein GTPase, alpha-subunit" []
narrow_synonym: "heterotrimeric G-protein GTPase, beta-subunit" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0031838
name: haptoglobin-hemoglobin complex
namespace: cellular_component
def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah]
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0031897
name: Tic complex
namespace: cellular_component
def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016]
exact_synonym: "chloroplast inner membrane translocase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031898
name: chromoplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz]
is_a: GO:0009509 ! chromoplast
is_a: GO:0009526 ! plastid envelope

[Term]
id: GO:0031899
name: chromoplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031900
name: chromoplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz]
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031901
name: early endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an early endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031902
name: late endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a late endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031903
name: microbody membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a microbody." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0042579 ! microbody

[Term]
id: GO:0031904
name: endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of an endosome." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0031905
name: early endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of an early endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031906
name: late endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a late endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031907
name: microbody lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a microbody." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044438 ! microbody part

[Term]
id: GO:0031908
name: glyoxysomal lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah]
is_a: GO:0031907 ! microbody lumen
relationship: part_of GO:0009514 ! glyoxysome

[Term]
id: GO:0031909
name: peroxisomal lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a peroxisome." [GOC:mah]
is_a: GO:0031907 ! microbody lumen
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0031910
name: cytostome
namespace: cellular_component
def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031911
name: cytoproct
namespace: cellular_component
def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031912
name: oral apparatus
namespace: cellular_component
def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189]
comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals.
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0031913
name: contractile vacuole pore
namespace: cellular_component
def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044437 ! vacuolar part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005884 ! actin filament
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031931
name: TORC 1 complex
namespace: cellular_component
def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy." [GOC:jh, PMID:15780592]
exact_synonym: "nutrient sensitive complex" []
exact_synonym: "TOR complex 1" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031932
name: TORC 2 complex
namespace: cellular_component
def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization." [GOC:jh, PMID:15780592]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031933
name: telomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0031934
name: mating-type region heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0031941
name: filamentous actin
namespace: cellular_component
def: "A two-stranded helical polymer of the protein actin." [GOC:mah]
comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'.
exact_synonym: "F-actin" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005884 ! actin filament

[Term]
id: GO:0031942
name: i-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274]
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031965
name: nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0031966
name: mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0031967
name: organelle envelope
namespace: cellular_component
def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]
subset: gosubset_prok
is_a: GO:0031975 ! envelope
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0043227 ! membrane-bound organelle

[Term]
id: GO:0031968
name: organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of an organelle envelope." [GOC:mah]
is_a: GO:0019867 ! outer membrane
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031969
name: chloroplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz]
is_a: GO:0042170 ! plastid membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031970
name: organelle envelope lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah]
exact_synonym: "organelle intermembrane space" []
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031972
name: chloroplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah]
exact_synonym: "chloroplast envelope lumen" []
is_a: GO:0009529 ! plastid intermembrane space
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031973
name: chromoplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah]
exact_synonym: "chromoplast envelope lumen" []
is_a: GO:0009529 ! plastid intermembrane space
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0031974
name: membrane-enclosed lumen
namespace: cellular_component
def: "The enclosed volume within a sealed membrane or between two sealed membranes." [GOC:add]
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0031975
name: envelope
namespace: cellular_component
def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer, also includes the space between layers." [GOC:mah, GOC:pz]
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0031976
name: plastid thylakoid
namespace: cellular_component
def: "Any thylakoid within a plastid." [GOC:pz]
is_a: GO:0009579 ! thylakoid
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0031977
name: thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044436 ! thylakoid part

[Term]
id: GO:0031978
name: plastid thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0031979
name: thylakoid lumen (sensu Cyanobacteria)
namespace: cellular_component
def: "The volume enclosed by a thylakoid membrane; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117)." [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030075 ! thylakoid (sensu Cyanobacteria)

[Term]
id: GO:0031980
name: mitochondrial lumen
namespace: cellular_component
def: "The volume enclosed by the mitochondrial inner membrane." [GOC:mah, GOC:pz]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0031981
name: nuclear lumen
namespace: cellular_component
def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031982
name: vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
subset: gosubset_prok
is_a: GO:0043226 ! organelle

[Term]
id: GO:0031983
name: vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
relationship: part_of GO:0031988 ! membrane-bound vesicle

[Term]
id: GO:0031984
name: organelle subcompartment
namespace: cellular_component
def: "A membrane-enclosed compartment that is a part of an organelle." [GOC:pz]
exact_synonym: "suborganelle compartment" []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0043227 ! membrane-bound organelle

[Term]
id: GO:0031985
name: Golgi cisterna
namespace: cellular_component
def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]
is_a: GO:0005795 ! Golgi stack
is_a: GO:0031984 ! organelle subcompartment

[Term]
id: GO:0031986
name: proteinoplast
namespace: cellular_component
def: "A leucoplast in which protein is stored." [GOC:pz]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0031988
name: membrane-bound vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031982 ! vesicle

[Term]
id: GO:0032002
name: interleukin-28 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta." [UniProtKB:rh]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0032009
name: early phagosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753]
exact_synonym: "early phagocytic vesicle" []
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032010
name: phagolysosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753]
related_synonym: "late phagocytic vesicle" []
related_synonym: "late phagosome" []
is_a: GO:0005767 ! secondary lysosome
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032019
name: mitochondrial cloud
namespace: cellular_component
def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166]
exact_synonym: "Balbiani body" []
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032021
name: NELF complex
namespace: cellular_component
def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062]
exact_synonym: "negative elongation factor complex" []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032039
name: integrator complex
namespace: cellular_component
def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0032040
name: small subunit processome
namespace: cellular_component
def: "A large ribonuclear protein complex containing the U3 snoRNA and associated proteins (28 in S. cerevisiae) that is involved in processing of the pre-18S rRNA to form the small ribosomal subunit." [PMID:12068309]
exact_synonym: "SSU processome" []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0032044
name: DSIF complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788]
exact_synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" []
exact_synonym: "DRB sensitivity inducing factor complex" []
exact_synonym: "Spt4-Spt5 complex" []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032045
name: guanyl-nucleotide exchange factor complex
namespace: cellular_component
def: "A protein complex that stimulates the exchange of guanyl nucleotides by a GTPase." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032046
name: micropexophagy-specific membrane apparatus
namespace: cellular_component
def: "A membrane-bound flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611]
exact_synonym: "micropexophagic apparatus" []
exact_synonym: "MIPA" []
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044437 ! vacuolar part

[Term]
id: GO:0032047
name: mitosome
namespace: cellular_component
def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria." [PMID:10361303, PMID:14614504]
exact_synonym: "crypton" []
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032059
name: bleb
namespace: cellular_component
def: "A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0032068
name: Type IV site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995]
exact_synonym: "Type IV restriction enzyme complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032116
name: cohesin loading complex
namespace: cellular_component
def: "A complex required for the loading of cohesin onto DNA prior to the establishment of cohesion. Appears to be eukaryotically conserved." [GOC:vw, PMID:10882066]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032117
name: horsetail-astral microtubule array
namespace: cellular_component
def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942]
exact_synonym: "HAA" []
is_a: GO:0005818 ! aster

[Term]
id: GO:0032123
name: deep fiber
namespace: cellular_component
def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189]
exact_synonym: "deep fibre" []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0031912 ! oral apparatus

[Term]
id: GO:0032126
name: eisosome
namespace: cellular_component
def: "Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p." [PMID:16496001]
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0032127
name: dense core granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense core granule." [GOC:mah]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031045 ! dense core granule

[Term]
id: GO:0032133
name: chromosome passenger complex
namespace: cellular_component
def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger comples coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain containing protein survivin, aurora kinase and INCENP." [GOC:vw, PMID:16824200]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0032144
name: 4-aminobutyrate transaminase complex
namespace: cellular_component
def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998]
exact_synonym: "ABAT complex" []
exact_synonym: "GABA transaminase complex" []
exact_synonym: "GABA-T complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032151
name: mitotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032152
name: meiotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032153
name: cell division site
namespace: cellular_component
def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane." [GOC:krc, PMID:12101122, PMID:15380095, TGD:ns]
exact_synonym: "cell division plane" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032154
name: cleavage furrow
namespace: cellular_component
def: "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin, is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
is_a: GO:0032155 ! cell division site part

[Term]
id: GO:0032155
name: cell division site part
namespace: cellular_component
def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah]
exact_synonym: "cell division plane part" []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0032156
name: septin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0032157
name: prospore contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555]
related_synonym: "meiotic contractile ring" []
broad_synonym: "actomyosin ring (sensu Saccharomyces)" []
broad_synonym: "cytokinetic ring (sensu Saccharomyces)" []
is_a: GO:0005826 ! contractile ring
relationship: part_of GO:0042764 ! prospore

[Term]
id: GO:0032158
name: septin band
namespace: cellular_component
def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032159
name: septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032160
name: septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244]
related_synonym: "septin bar" []
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032161
name: cleavage apparatus septin structure
namespace: cellular_component
def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555]
is_a: GO:0032155 ! cell division site part
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032162
name: mating projection septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0032158 ! septin band

[Term]
id: GO:0032163
name: hyphal septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:16151244, GOC:krc, GOC:mah]
is_a: GO:0032158 ! septin band

[Term]
id: GO:0032164
name: hyphal septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap

[Term]
id: GO:0032165
name: prospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032166
name: chlamydospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032167
name: septin patch
namespace: cellular_component
def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555]
comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure.
is_obsolete: true

[Term]
id: GO:0032168
name: hyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032169
name: prospore septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
relationship: part_of GO:0042764 ! prospore

[Term]
id: GO:0032170
name: pseudohyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032171
name: germ tube septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap

[Term]
id: GO:0032172
name: germ tube septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244]
is_a: GO:0005940 ! septin ring
relationship: part_of GO:0032179 ! germ tube

[Term]
id: GO:0032173
name: septin collar
namespace: cellular_component
def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032174
name: bud neck septin collar
namespace: cellular_component
def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032173 ! septin collar

[Term]
id: GO:0032175
name: mating projection septin ring
namespace: cellular_component
def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032176
name: split septin rings
namespace: cellular_component
def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032177
name: bud neck split septin rings
namespace: cellular_component
def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032176 ! split septin rings

[Term]
id: GO:0032178
name: medial membrane band
namespace: cellular_component
def: "A sterol rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003]
related_synonym: "sterol-rich membrane band" []
is_a: GO:0032155 ! cell division site part

[Term]
id: GO:0032179
name: germ tube
namespace: cellular_component
def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032195
name: post-lysosomal vacuole
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012]
is_a: GO:0005773 ! vacuole
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0032221
name: Clr6 histone deacetylase complex
namespace: cellular_component
def: "A eukaryotically conserved histone deacetylse complex composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; homologs thereof in other species)." [PMID:12773392]
is_a: GO:0000118 ! histone deacetylase complex

[Term]
id: GO:0032279
name: asymmetric synapse
namespace: cellular_component
def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density." [GOC:dgh, GOC:ef]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0032280
name: symmetric synapse
namespace: cellular_component
def: "A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density." [GOC:dgh, GOC:ef]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0032281
name: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the centre of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef]
related_synonym: "AMPA receptor " []
exact_synonym: "AMPA-selective glutamate receptor complex" []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0032282
name: plastid acetyl-CoA carboxylase complex
namespace: cellular_component
def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah]
exact_synonym: "plastid ACCase complex" []
is_a: GO:0009317 ! acetyl-CoA carboxylase complex
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0032283
name: plastid acetate CoA-transferase complex
namespace: cellular_component
def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah]
is_a: GO:0009329 ! acetate CoA-transferase complex
relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex

[Term]
id: GO:0032284
name: plastid biotin carboxylase complex
namespace: cellular_component
def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah]
is_a: GO:0009343 ! biotin carboxylase complex
relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex

[Term]
id: GO:0032299
name: ribonuclease H2 complex
namespace: cellular_component
def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815]
exact_synonym: "RNase H2 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032300
name: mismatch repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032301
name: MutSalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803]
exact_synonym: "MSH2/MSH6 complex" []
broad_synonym: "MMR complex" []
is_a: GO:0032300 ! mismatch repair complex

[Term]
id: GO:0032302
name: MutSbeta complex
namespace: cellular_component
def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803]
exact_synonym: "MSH2/MSH3 complex" []
broad_synonym: "MMR complex" []
is_a: GO:0032300 ! mismatch repair complex

[Term]
id: GO:0032311
name: angiogenin-PRI complex
namespace: cellular_component
def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787]
exact_synonym: "angiogenin-placental ribonuclease inhibitor complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0032389
name: MutLalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk]
exact_synonym: "MLH1/PMS2 complex" []
broad_synonym: "MMR complex" []
is_a: GO:0032300 ! mismatch repair complex

[Term]
id: GO:0032390
name: MutLbeta complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk]
exact_synonym: "MLH1/PMS1 complex" []
broad_synonym: "MMR complex" []
is_a: GO:0032300 ! mismatch repair complex

[Term]
id: GO:0032391
name: photoreceptor connecting cilium
namespace: cellular_component
def: "A 9+0 cilium that forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments." [PMID:15917207, PMID:8718680]
related_synonym: "photoreceptor cilium" []
is_a: GO:0031513 ! nonmotile primary cilium

[Term]
id: GO:0032398
name: MHC class Ib protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0032419
name: extrinsic to lysosome membrane
namespace: cellular_component
def: "Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region." [GOC:mah]
exact_synonym: "extrinsic to lysosomal membrane" []
is_a: GO:0000306 ! extrinsic to vacuolar membrane
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0032420
name: stereocilium
namespace: cellular_component
def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0032421
name: stereocilium bundle
namespace: cellular_component
def: "An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137]
exact_synonym: "stereocilia bundle" []
is_a: GO:0043232 ! intracellular non-membrane-bound organelle

[Term]
id: GO:0032426
name: stereocilium bundle tip
namespace: cellular_component
def: "The end of a stereocilium bundle, distal to the site of the bundle's attachment to the apical cell surface." [GOC:ecd, PMID:17021180]
related_synonym: "stereocilium tip" []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0032421 ! stereocilium bundle

[Term]
id: GO:0032432
name: actin filament bundle
namespace: cellular_component
def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0032433
name: filopodium tip
namespace: cellular_component
def: "The end of a filopodium distal to the body of the cell." [GOC:mah]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0032437
name: cuticular plate
namespace: cellular_component
def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0032444
name: activin responsive factor complex
namespace: cellular_component
def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972]
comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor).
exact_synonym: "ARF complex" []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0032449
name: CBM complex
namespace: cellular_component
def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454]
exact_synonym: "CARMA1-BCL10-Malt1 complex" []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0032473
name: external side of mitochondrial outer membrane
namespace: cellular_component
def: "The external (cytoplasmic face) of the mitochondrial outer membrane." [GOC:mah]
related_synonym: "external side of mitochondrial envelope" []
exact_synonym: "cytosolic side of mitochondrial outer membrane" []
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0032476
name: decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0032477
name: homodimeric decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123]
is_a: GO:0032476 ! decaprenyl diphosphate synthase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032478
name: heterotetrameric decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123]
is_a: GO:0032476 ! decaprenyl diphosphate synthase complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0035003
name: subapical complex
namespace: cellular_component
def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
broad_synonym: "SAC" []
is_a: GO:0005911 ! intercellular junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0035012
name: polytene chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a polytene chromosome." [GOC:bf]
is_a: GO:0000781 ! chromosome, telomeric region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0035030
name: phosphoinositide 3-kinase complex, class IA
namespace: cellular_component
def: "A complex containing a heterodimer of a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit bound to a SH2 domain-containing regulatory (adaptor) subunit. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [GOC:bf, PMID:9255069]
exact_synonym: "class IA PI3K complex" []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0035031
name: phosphoinositide 3-kinase complex, class IB
namespace: cellular_component
def: "A complex containing a heterodimer of a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [GOC:bf, PMID:9255069]
exact_synonym: "class IB PI3K complex" []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0035032
name: phosphoinositide 3-kinase complex, class III
namespace: cellular_component
def: "A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069]
exact_synonym: "class III PI3K complex" []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0035059
name: RCAF complex
namespace: cellular_component
def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219]
exact_synonym: "replication-coupling assembly factor complex" []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0035060
name: brahma complex
namespace: cellular_component
def: "A multi-subunit ATP-dependent chromatin remodeling complex, a counterpart of the SWI/SNF complex that contains the ATPase product of the Drosophila brahma gene." [GOC:bf, PMID:10809665, PMID:12482982]
exact_synonym: "BRM complex" []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0035061
name: interchromatin granule
namespace: cellular_component
def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
exact_synonym: "ICG" []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0035062
name: omega speckle
namespace: cellular_component
def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
is_a: GO:0016607 ! nuclear speck

[Term]
id: GO:0035068
name: micro-ribonucleoprotein complex
namespace: cellular_component
def: "A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA." [GOC:bf, PMID:14559182]
exact_synonym: "miRNP complex" []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0035085
name: cilium axoneme
namespace: cellular_component
def: "The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684]
is_a: GO:0005930 ! axoneme
is_a: GO:0044441 ! cilium part

[Term]
id: GO:0035086
name: flagellar axoneme
namespace: cellular_component
def: "The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684]
is_a: GO:0005930 ! axoneme
is_a: GO:0044442 ! flagellar part (sensu Eukaryota)

[Term]
id: GO:0035097
name: histone methyltransferase complex
namespace: cellular_component
def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0035098
name: ESC/E(Z) complex
namespace: cellular_component
def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12." [GOC:bf, PMID:12408863, PMID:12408864]
exact_synonym: "Extra Sex Combs/Enhancer of Zeste complex" []
is_a: GO:0031519 ! PcG protein complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0035101
name: FACT complex
namespace: cellular_component
def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108]
exact_synonym: "Facilitates chromatin transcription complex" []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0035102
name: PRC1 complex
namespace: cellular_component
def: "An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays." [GOC:bf, PMID:10412979]
exact_synonym: "Polycomb repressive complex 1" []
is_a: GO:0031519 ! PcG protein complex

[Term]
id: GO:0035145
name: exon-exon junction complex
namespace: cellular_component
def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]
exact_synonym: "EJC" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0035182
name: ring canal outer rim
namespace: cellular_component
def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006]
comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'.
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0045172 ! ring canal (sensu Insecta)

[Term]
id: GO:0035183
name: ring canal inner rim
namespace: cellular_component
def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858]
comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'.
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0045172 ! ring canal (sensu Insecta)

[Term]
id: GO:0035189
name: Rb-E2F complex
namespace: cellular_component
def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073]
exact_synonym: "retinoblastoma-E2F complex" []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0035230
name: cytoneme
namespace: cellular_component
def: "A long, thin and polarized actin-based extension that projects from a cell and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0035253
name: ciliary rootlet
namespace: cellular_component
def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [PMID:12427867]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044441 ! cilium part

[Term]
id: GO:0035267
name: TIP60 histone acetyltransferase complex
namespace: cellular_component
def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A." [GOC:ecd, PMID:10966108]
exact_synonym: "TIP60 histone acetylase complex" []
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0035301
name: Hedgehog signaling complex
namespace: cellular_component
def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936]
exact_synonym: "HSC" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0042022
name: interleukin-12 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-12; comprises an alpha and a beta subunit." [GOC:mah, PMID:10971505]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0042025
name: host cell nucleus
namespace: cellular_component
def: "The nucleus of a host cell." [GOC:jl]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0043656 ! intracellular region of host

[Term]
id: GO:0042101
name: T cell receptor complex
namespace: cellular_component
def: "A receptor complex usually consisting of a TCR- (T cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T cell activation." [GOC:jl, ISBN:0120781859]
exact_synonym: "T cell receptor complex" []
exact_synonym: "T lymphocyte receptor complex" []
exact_synonym: "T-lymphocyte receptor complex" []
exact_synonym: "TCR" []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0001772 ! immunological synapse

[Term]
id: GO:0042105
name: alpha-beta T cell receptor complex
namespace: cellular_component
exact_synonym: "alpha-beta T lymphocyte receptor complex" []
exact_synonym: "alpha-beta T-cell receptor complex" []
exact_synonym: "alpha-beta T-lymphocyte receptor complex" []
exact_synonym: "alpha-beta TCR complex" []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042106
name: gamma-delta T cell receptor complex
namespace: cellular_component
exact_synonym: "gamma-delta T lymphocyte receptor complex" []
exact_synonym: "gamma-delta T-cell receptor complex" []
exact_synonym: "gamma-delta T-lymphocyte receptor complex" []
exact_synonym: "gamma-delta TCR complex" []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042151
name: nematocyst
namespace: cellular_component
def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [GOC:jl, UniProtKB:P01533]
exact_synonym: "cnidocyst" []
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0042170
name: plastid membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0042175
name: nuclear envelope-endoplasmic reticulum network
namespace: cellular_component
def: "The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum." [GOC:jl]
exact_synonym: "NE-ER continuum" []
exact_synonym: "NE-ER network" []
exact_synonym: "nuclear envelope-endoplasmic reticulum continuum" []
exact_synonym: "nuclear envelope-ER network" []
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0042272
name: nuclear RNA export factor complex
namespace: cellular_component
def: "A complex of NXF1 and NXF2 required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [UniProtKB:Q9U1H9]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0042382
name: paraspeckles
namespace: cellular_component
def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0042383
name: sarcolemma
namespace: cellular_component
def: "The outer membrane of a muscle fiber, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]
is_a: GO:0005886 ! plasma membrane

[Term]
id: GO:0042385
name: myosin III complex
namespace: cellular_component
def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0042405
name: nuclear inclusion body
namespace: cellular_component
def: "Intranuclear foci at which aggregated proteins have been sequestered." [GOC:jl]
is_a: GO:0016234 ! inclusion body
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0042406
name: extrinsic to endoplasmic reticulum membrane
namespace: cellular_component
def: "Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/]
exact_synonym: "extrinsic to ER membrane" []
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0042470
name: melanosome
namespace: cellular_component
def: "A tissue-specific, membrane bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0042555
name: MCM complex
namespace: cellular_component
def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]
exact_synonym: "mini-chromosome maintenance complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043596 ! replication fork (sensu Eukaryota)

[Term]
id: GO:0042563
name: importin alpha-subunit nuclear export complex
namespace: cellular_component
def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042564
name: NLS-dependent protein nuclear import complex
namespace: cellular_component
def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042565
name: RNA nuclear export complex
namespace: cellular_component
def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042566
name: hydrogenosome
namespace: cellular_component
def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569]
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042567
name: insulin-like growth factor ternary complex
namespace: cellular_component
def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
exact_synonym: "IGF ternary complex" []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042568
name: insulin-like growth factor binary complex
namespace: cellular_component
def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
exact_synonym: "IGF binary complex" []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042571
name: immunoglobulin complex, circulating
namespace: cellular_component
def: "A multi-subunit complex that functions as an antibody and circulates in the blood, lymph, mucosal areas, and other fluids of the body. In its basic form, circulating immunoglobulin is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [ISBN:0781735149]
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0042575
name: DNA polymerase complex
namespace: cellular_component
def: "Any of the multimeric enzyme complexes involved in template directed synthesis of DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0042579
name: microbody
namespace: cellular_component
def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732]
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042580
name: mannosome
namespace: cellular_component
def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531]
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0042581
name: specific granule
namespace: cellular_component
def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544, PMID:7334549]
exact_synonym: "secondary granule" []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042582
name: azurophil granule
namespace: cellular_component
def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, http://cancerweb.ncl.ac.uk/]
exact_synonym: "primary granule" []
is_a: GO:0005766 ! primary lysosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042583
name: chromaffin granule
namespace: cellular_component
def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042584
name: chromaffin granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042583 ! chromaffin granule

[Term]
id: GO:0042585
name: germinal vesicle
namespace: cellular_component
def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0001674 ! female germ cell nucleus

[Term]
id: GO:0042587
name: glycogen granule
namespace: cellular_component
def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957]
exact_synonym: "glycogen particle" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042588
name: zymogen granule
namespace: cellular_component
def: "A membrane-bound, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042589
name: zymogen granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042588 ! zymogen granule

[Term]
id: GO:0042597
name: periplasmic space
namespace: cellular_component
def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative bacteria) or inner membrane and cell wall (fungi)." [GOC:go_curators]
subset: gosubset_prok
exact_synonym: "periplasm" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042598
name: vesicular fraction
namespace: cellular_component
def: "Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: gosubset_prok
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0042599
name: lamellar body
namespace: cellular_component
def: "A membrane bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:jl, PMID:12243725]
exact_synonym: "keratinosome" []
exact_synonym: "lamellar granule" []
exact_synonym: "membrane-coating granule" []
exact_synonym: "Odland body" []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042600
name: chorion
namespace: cellular_component
def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544]
comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO.
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0042601
name: forespore (sensu Bacteria)
namespace: cellular_component
def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:jl, ISBN:0697286029]
is_a: GO:0042763 ! immature spore

[Term]
id: GO:0042603
name: capsule
namespace: cellular_component
def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules play an important role in pathogenicity, preventing phagocytosis by eukaryotic cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0042604
name: capsule (sensu Fungi)
namespace: cellular_component
def: "A protective structure attached externally to the cell wall and composed primarily of polysaccharides. Capsules play an important role in pathogenicity, preventing phagocytosis by eukaryotic cells. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:jl]
is_a: GO:0042603 ! capsule

[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen" [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0042612
name: MHC class I protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]
comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'.
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042622
name: photoreceptor outer segment membrane
namespace: cellular_component
def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl]
is_a: GO:0016020 ! membrane
is_a: GO:0044441 ! cilium part
relationship: part_of GO:0001750 ! photoreceptor outer segment

[Term]
id: GO:0042627
name: chylomicron
namespace: cellular_component
def: "A particle composed of a central core of triglycerides surrounded by a protein-phospholipid coating. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html, http://cancerweb.ncl.ac.uk/]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0042629
name: mast cell granule
namespace: cellular_component
def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0042641
name: actomyosin
namespace: cellular_component
def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0042642
name: actomyosin, myosin complex part
namespace: cellular_component
def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0016459 ! myosin complex
relationship: part_of GO:0042641 ! actomyosin

[Term]
id: GO:0042643
name: actomyosin, actin part
namespace: cellular_component
def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0005884 ! actin filament
relationship: part_of GO:0042641 ! actomyosin

[Term]
id: GO:0042644
name: chloroplast nucleoid
namespace: cellular_component
def: "The region of a chloroplast to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0042645
name: mitochondrial nucleoid
namespace: cellular_component
def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0042646
name: plastid nucleoid
namespace: cellular_component
def: "The region of a plastid to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0042647
name: proplastid nucleoid
namespace: cellular_component
def: "The region of a proplastid to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
relationship: part_of GO:0009571 ! proplastid stroma

[Term]
id: GO:0042648
name: chloroplast chromosome
namespace: cellular_component
def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl]
is_a: GO:0009508 ! plastid chromosome
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0042644 ! chloroplast nucleoid

[Term]
id: GO:0042649
name: prothylakoid
namespace: cellular_component
def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175]
is_a: GO:0009579 ! thylakoid
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0042650
name: prothylakoid membrane
namespace: cellular_component
def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175]
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0042649 ! prothylakoid

[Term]
id: GO:0042651
name: thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of any thylakoid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044436 ! thylakoid part

[Term]
id: GO:0042652
name: respiratory chain complex I, peripheral segment (sensu Eukaryota)
namespace: cellular_component
def: "The peripheral segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jic, ISBN:0716749556]
exact_synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment (sensu Eukaryota)" []
exact_synonym: "NADH-Q oxidoreductase complex, peripheral segment (sensu Eukaryota)" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005747 ! respiratory chain complex I (sensu Eukaryota)

[Term]
id: GO:0042653
name: respiratory chain complex I, membrane segment (sensu Eukaryota)
namespace: cellular_component
def: "The membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jic, ISBN:0716749556]
exact_synonym: "NADH-Q oxidoreductase complex, membrane segment (sensu Eukaryota)" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005747 ! respiratory chain complex I (sensu Eukaryota)

[Term]
id: GO:0042709
name: succinate-CoA ligase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl]
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0042716
name: chromatophore
namespace: cellular_component
def: "A pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria which is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle." [GOC:jl, ISBN:0395825172, PMID:11867431]
comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin.
subset: gosubset_prok
related_synonym: "thylakoid (sensu Bacteria)" []
related_synonym: "thylakoid (sensu Proteobacteria)" []
exact_synonym: "chromatophore vesicle" []
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0042717
name: chromatophore membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chromatophore, a pigment-bearing vesicle found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0042716 ! chromatophore

[Term]
id: GO:0042718
name: yolk granule
namespace: cellular_component
def: "Discrete structures that partition the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042719
name: mitochondrial intermembrane space protein transporter complex
namespace: cellular_component
def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]
narrow_synonym: "Tim9-Tim10 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005758 ! mitochondrial intermembrane space

[Term]
id: GO:0042720
name: mitochondrial inner membrane peptidase complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]
narrow_synonym: "IMP" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0042721
name: mitochondrial inner membrane protein insertion complex
namespace: cellular_component
def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765]
narrow_synonym: "Tim22 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0042729
name: DASH complex
namespace: cellular_component
def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role chromosome segregation and spindle stability." [GOC:jl, PMID:11782438, PMID:11799062]
comment: Note that although this complex has so far only been described in Saccharomyces, it is likely to be conserved in other eukaryotes.
exact_synonym: "Dam1 complex" []
exact_synonym: "DDD complex" []
exact_synonym: "Duo1p-Dam1p-Dad1p complex" []
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore
relationship: part_of GO:0005828 ! kinetochore microtubule

[Term]
id: GO:0042734
name: presynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0016020 ! membrane
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0042735
name: protein body
namespace: cellular_component
def: "Membrane-bound plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047]
is_a: GO:0043231 ! intracellular membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042757
name: giant axon
namespace: cellular_component
def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030424 ! axon

[Term]
id: GO:0042763
name: immature spore
namespace: cellular_component
def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172]
related_synonym: "forespore" []
related_synonym: "prospore" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042764
name: prospore
namespace: cellular_component
def: "A spore, of the type seen in some species of fungi and protist, undergoing development, usually consisting of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s)." [GOC:go_curators]
exact_synonym: "forespore (sensu Fungi)" []
is_a: GO:0042763 ! immature spore

[Term]
id: GO:0042765
name: GPI-anchor transamidase complex
namespace: cellular_component
def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity.
exact_synonym: "GPIT complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane

[Term]
id: GO:0042788
name: polysomal ribosome
namespace: cellular_component
def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl]
broad_synonym: "active ribosome" []
is_a: GO:0005840 ! ribosome
relationship: part_of GO:0005844 ! polysome

[Term]
id: GO:0042807
name: central vacuole
namespace: cellular_component
def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [http://www.wikipedia.org/]
is_a: GO:0000325 ! vacuole (sensu Magnoliophyta)

[Term]
id: GO:0042824
name: MHC class I peptide loading complex
namespace: cellular_component
def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934]
comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0042825
name: TAP complex
namespace: cellular_component
def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934]
exact_synonym: "transporter associated with antigen presentation" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0042824 ! MHC class I peptide loading complex

[Term]
id: GO:0042827
name: platelet dense granule
namespace: cellular_component
def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. Contain a highly condensed core consisting of serotonin, calcium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682]
exact_synonym: "bull's eye body" []
exact_synonym: "platelet dense body" []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042995
name: cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043005
name: neuron projection
namespace: cellular_component
def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
exact_synonym: "neuronal cell projection" []
narrow_synonym: "neurite" []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0043020
name: NADPH oxidase complex
namespace: cellular_component
def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]
related_synonym: "respiratory-burst oxidase" []
narrow_synonym: "flavocytochrome b558" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0043025
name: cell soma
namespace: cellular_component
def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
exact_synonym: "cell body" []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043033
name: isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591]
broad_synonym: "debranching enzyme" []
broad_synonym: "debranching enzyme complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043034
name: costamere
namespace: cellular_component
def: "Vinculin-containing myofibril attachment site which connects the Z-discs to the sarcolemma." [GOC:jl, ISBN:0198506732]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0043036
name: starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
exact_synonym: "starch granule" []
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0043073
name: germ cell nucleus
namespace: cellular_component
def: "The nucleus of a germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:go_curators, http://cancerweb.ncl.ac.uk]
exact_synonym: "germ-cell nucleus" []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043074
name: microsporocyte nucleus
namespace: cellular_component
def: "OBSOLETE. The nucleus of the cell in which meiosis will occur, resulting in four microspores called pollen mother cell or microsporocyte." [GOC:jl, http://www.bio.uu.nl/~palaeo/glossary/index.htm]
comment: This term was made obsolete because it was wrongly defined. To update annotations, consider the cellular component term 'microsporocyte nucleus ; GO:0048556'.
related_synonym: "pollen mother cell nucleus" []
is_obsolete: true

[Term]
id: GO:0043075
name: sperm cell nucleus (sensu Magnoliophyta)
namespace: cellular_component
def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl]
comment: This term was made obsolete because the definition was incorrect. To update annotations, consider the cellular component term 'generative cell nucleus ; GO:0048555'.
exact_synonym: "pollen germ cell nucleus" []
exact_synonym: "pollen germ-cell nucleus" []
is_obsolete: true

[Term]
id: GO:0043076
name: megasporocyte nucleus
namespace: cellular_component
def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153]
exact_synonym: "megaspore mother cell nucleus" []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043078
name: polar nucleus
namespace: cellular_component
def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043079
name: antipodal cell nucleus
namespace: cellular_component
def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [GOC:jl, http://cancerweb.ncl.ac.uk]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043080
name: female germ cell nucleus (sensu Metazoa)
namespace: cellular_component
def: "The nucleus of the female germ cell, a cell specialized to produce haploid gametes, and its descendents. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:jl]
exact_synonym: "female germ-cell nucleus (sensu Animalia)" []
is_a: GO:0001674 ! female germ cell nucleus

[Term]
id: GO:0043081
name: male germ cell nucleus (sensu Metazoa)
namespace: cellular_component
def: "The nucleus of the male germ cell, a cell specialized to produce haploid gametes, and its descendents. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:jl]
exact_synonym: "male germ-cell nucleus (sensu Metazoa)" []
is_a: GO:0001673 ! male germ cell nucleus

[Term]
id: GO:0043082
name: egg cell nucleus (sensu Viridiplantae)
namespace: cellular_component
def: "The nucleus of a plant egg cell, the female gamete, at the micropylar end of the embryo and its descendents. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [GOC:jl]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043083
name: synaptic cleft
namespace: cellular_component
def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0043159
name: acrosomal matrix
namespace: cellular_component
def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729]
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0001669 ! acrosome

[Term]
id: GO:0043160
name: acrosomal lumen
namespace: cellular_component
def: "The volume enclosed within the acrosome membrane." [GOC:go_curators]
is_a: GO:0043202 ! lysosomal lumen
relationship: part_of GO:0001669 ! acrosome

[Term]
id: GO:0043186
name: P granule
namespace: cellular_component
def: "A small protein and RNA containing electron dense organelle, not surrounded by a membrane, that is associated with germ nuclei in the gonad and localized to germ cells and their precursors throughout development." [GOC:kva, PMID:11262230]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0045495 ! pole plasm

[Term]
id: GO:0043187
name: cell septum surface
namespace: cellular_component
def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators]
broad_synonym: "septum surface" []
is_a: GO:0044457 ! cell septum part

[Term]
id: GO:0043188
name: cell septum edging
namespace: cellular_component
def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw]
exact_synonym: "septum edging (sensu Fungi)" []
broad_synonym: "septum edging" []
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! cell wall (sensu Fungi)

[Term]
id: GO:0043189
name: H4/H2A histone acetyltransferase complex
namespace: cellular_component
def: "A multisubunit complex responsible for acetylation of histones H4 and H2A. In yeast, the complex has 12 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:jl, PMID:14966270]
exact_synonym: "H4/H2A HAT complex" []
narrow_synonym: "NuA4" []
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0043190
name: ATP-binding cassette (ABC) transporter complex
namespace: cellular_component
def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In bacteria and archaebacteria, ABC transporters also recruit substrate binding proteins to bind substrate external to the cell and deliver it to the transporter." [GOC:jl, PMID:11421269, PMID:15111107]
subset: gosubset_prok
narrow_synonym: "ABC-type efflux permease activity" []
narrow_synonym: "ABC-type efflux porter activity" []
narrow_synonym: "ABC-type uptake permease activity" []
narrow_synonym: "ATP-binding cassette (ABC) transporter activity" []
narrow_synonym: "mating pheromone exporter" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043191
name: ATP-binding cassette (ABC) transporter complex (sensu Eukaryota)
namespace: cellular_component
def: "ATP-binding cassette (ABC) transporter complex (sensu Eukarya) A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jl, PMID:11421269, PMID:15111107]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0043192
name: ATP-binding cassette (ABC) transporter complex (sensu Bacteria and Archaea)
namespace: cellular_component
def: "A complex for the transport of metabolites into and out of the cell, comprised of a permease domain integral to the plasma membrane, a membrane associated ATP-binding domain, and a periplasmic (in Gram-negative organims) or membrane anchored (in Gram-positive organisms) substrate-binding domain. The substrate-binding domain is not found in the efflux form. These domains can occur on one or more polypeptides. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0043194
name: initial segment
namespace: cellular_component
def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0043195
name: terminal button
namespace: cellular_component
def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln]
exact_synonym: "bouton" []
exact_synonym: "synaptic bouton" []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0043196
name: varicosity
namespace: cellular_component
def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0043197
name: dendritic spine
namespace: cellular_component
def: "Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043198
name: dendritic shaft
namespace: cellular_component
def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043202
name: lysosomal lumen
namespace: cellular_component
def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0043203
name: axon hillock
namespace: cellular_component
def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043025 ! cell soma

[Term]
id: GO:0043204
name: perikaryon
namespace: cellular_component
def: "The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043025 ! cell soma

[Term]
id: GO:0043205
name: fibril
namespace: cellular_component
def: "Extracellular matrix material consisting of polysaccharides and protein." [PMID:12704238]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! extracellular matrix (sensu Metazoa)

[Term]
id: GO:0043209
name: myelin sheath
namespace: cellular_component
def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:jl, http://en.wikipedia.org/]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0043218
name: compact myelin
namespace: cellular_component
def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043219
name: lateral loop
namespace: cellular_component
def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043220
name: Schmidt-Lanterman cleft
namespace: cellular_component
def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman clefts occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043222
name: SMC/kleisin ring complex
namespace: cellular_component
def: "A molecular ring complex composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1 and Smc3, and the kleisin protein Scc1." [GOC:jl, PMID:12667442]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0043223
name: cytoplasmic SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
exact_synonym: "cytoplasmic cullin complex" []
exact_synonym: "cytoplasmic SCF complex" []
exact_synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0043224
name: nuclear SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
exact_synonym: "nuclear cullin complex" []
exact_synonym: "nuclear SCF complex" []
exact_synonym: "nuclear Skp1/Cul1/F-box protein complex" []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0043226
name: organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_generic
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0043227
name: membrane-bound organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043228
name: non-membrane-bound organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043226 ! organelle
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]
subset: gosubset_prok
is_a: GO:0043226 ! organelle
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0043231
name: intracellular membrane-bound organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043227 ! membrane-bound organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043232
name: intracellular non-membrane-bound organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043228 ! non-membrane-bound organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043233
name: organelle lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear membrane lumen." [GOC:jl]
is_a: GO:0031974 ! membrane-enclosed lumen
is_a: GO:0044422 ! organelle part

[Term]
id: GO:0043234
name: protein complex
namespace: cellular_component
def: "Any protein group composed of two or more subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:go_curators]
comment: Note that although at some level almost all cellular components can be thought of as protein complexes, this term is intended to exclude structures composed of the same repeating subunit or subunits, for example microtubules. Protein complexes encompassed by this term are generally not structural, and usually have a defined set of subunits.
subset: goslim_generic
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0043235
name: receptor complex
namespace: cellular_component
def: "Any protein group composed of two or more subunits, which may or may not be identical, which undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043240
name: Fanconi anaemia nuclear complex
namespace: cellular_component
def: "A protein complex composed of the Fanconi anaemia (FA) proteins A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]
exact_synonym: "FA complex" []
exact_synonym: "FA nuclear complex" []
exact_synonym: "Fanconi anaemia complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0043245
name: extraorganismal space
namespace: cellular_component
def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl]
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0043246
name: megasome
namespace: cellular_component
def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [http://cancerweb.ncl.ac.uk/, PMID:11206117, PMID:1999020]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0043253
name: chloroplast ribosome
namespace: cellular_component
def: "A ribosome contained within a chloroplast." [GOC:ecd]
is_a: GO:0009547 ! plastid ribosome
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0043256
name: laminin complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354]
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0043257
name: laminin-8 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043258
name: laminin-9 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha4, beta2 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043259
name: laminin-10 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta1 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043260
name: laminin-11 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta2 and gamma1." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043261
name: laminin-12 complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma3." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043263
name: cellulosome
namespace: cellular_component
def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609]
subset: gosubset_prok
is_a: GO:0043264 ! extracellular non-membrane-bound organelle

[Term]
id: GO:0043264
name: extracellular non-membrane-bound organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043228 ! non-membrane-bound organelle
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0043265
name: ectoplasm
namespace: cellular_component
def: "Granule free cytoplasm, lying immediately below the plasma membrane." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043291
name: RAVE complex
namespace: cellular_component
def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802]
broad_synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043292
name: contractile fiber
namespace: cellular_component
def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]
related_synonym: "muscle motor activity" []
exact_synonym: "contractile fibre" []
broad_synonym: "muscle fiber" []
broad_synonym: "muscle fibre" []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043293
name: apoptosome
namespace: cellular_component
def: "A multisubunit protein complex involved in the activation of apoptosis. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0043294
name: mitochondrial glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031027 ! glutamate synthase complex (NADH)
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0043296
name: apical junction complex
namespace: cellular_component
def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, PMID:12525486, PMID:15196556]
is_a: GO:0005911 ! intercellular junction
relationship: part_of GO:0016327 ! apicolateral plasma membrane

[Term]
id: GO:0043332
name: mating projection tip
namespace: cellular_component
def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc]
narrow_synonym: "conjugation tube tip" []
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0043384
name: pre-T cell receptor complex
namespace: cellular_component
def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932]
exact_synonym: "pre-T lymphocyte receptor complex" []
exact_synonym: "pre-T-cell receptor complex" []
exact_synonym: "pre-T-lymphocyte receptor complex" []
exact_synonym: "pre-TCR complex" []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0043493
name: phage terminase complex
namespace: cellular_component
def: "A complex of a large and small subunit which catalyze the packaging of DNA into phage heads. Note that not all phage terminases have this structure, some exist as single polypeptides." [GOC:mlg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0030430 ! host cell cytoplasm

[Term]
id: GO:0043494
name: Rik1-E3 ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that consists of (minimally) cullin, RING finger, methyltransferase, Rik1 WD repeat protein, Raf1 and Raf2. Required to regulate heterchromatin formation by RNAi and for histone H3K9 methylation." [GOC:jl, PMID:16024659, PMID:16040243]
exact_synonym: "Rik1 E3 ubiquitin ligase complex" []
is_a: GO:0031465 ! Cul4B-RING ubiquitin ligase complex

[Term]
id: GO:0043505
name: centromere-specific nucleosome
namespace: cellular_component
def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641]
exact_synonym: "centromere specific nucleosome" []
exact_synonym: "centromeric nucleosome" []
is_a: GO:0000786 ! nucleosome
relationship: part_of GO:0000939 ! inner kinetochore of condensed chromosome

[Term]
id: GO:0043509
name: activin A complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043510
name: activin B complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043511
name: inhibin complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043512
name: inhibin A complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043513
name: inhibin B complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043514
name: interleukin-12 complex
namespace: cellular_component
def: "Secreted heterodimeric cytokine complex composed of an interleukin-12 alpha and an interleukin-12 beta subunit." [GOC:ebc]
exact_synonym: "IL-12 complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043527
name: tRNA methyltransferase complex
namespace: cellular_component
def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043528
name: tRNA (m2G10) methyltransferase complex
namespace: cellular_component
def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0043529
name: GET complex
namespace: cellular_component
def: "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340]
exact_synonym: "Golgi to ER Traffic complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0043540
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
namespace: cellular_component
def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, InterPro:SO]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0043541
name: UDP-N-acetylglucosamine transferase complex
namespace: cellular_component
def: "A heterooligomeric complex that in yeast is composed of a catalytic subunit, Alg13p, and an anchoring subunit, Alg14p. Catalyses the second step of dolichyl-linked oligosaccharide synthesis of GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc." [PMID:15615718, PMID:16100110, PMID:16100113]
comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0043564
name: Ku70:Ku80 complex
namespace: cellular_component
def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983, UniProtKB:P12956]
exact_synonym: "Ku70:Ku80 heterodimer" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0043590
name: bacterial nucleoid
namespace: cellular_component
def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid

[Term]
id: GO:0043591
name: endospore external encapsulating structure
namespace: cellular_component
def: "The structures that lie outside the inner membrane and surround the entire endospore." [GOC:go_curators]
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0043592
name: exosporium
namespace: cellular_component
def: "The outer-most layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg]
related_synonym: "epispore" []
related_synonym: "exospore" []
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043593
name: endospore coat
namespace: cellular_component
def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg]
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043594
name: outer endospore membrane
namespace: cellular_component
def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg]
is_a: GO:0019867 ! outer membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043595
name: endospore cortex
namespace: cellular_component
def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg]
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043596
name: replication fork (sensu Eukaryota)
namespace: cellular_component
def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jl]
is_a: GO:0005657 ! replication fork
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0043597
name: replication fork (sensu Bacteria and Archaea)
namespace: cellular_component
def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [GOC:jl]
is_a: GO:0005657 ! replication fork
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0043598
name: DNA replication factor C complex (sensu Bacteria and Archaea)
namespace: cellular_component
def: "A complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [PMID:14646196, PMID:16172520]
is_a: GO:0005663 ! DNA replication factor C complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043600 ! replisome (sensu Bacteria and Archaea)

[Term]
id: GO:0043599
name: DNA replication factor C complex (sensu Eukaryota)
namespace: cellular_component
def: "A complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [PMID:14614842]
is_a: GO:0005663 ! DNA replication factor C complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! replisome (sensu Eukaryota)

[Term]
id: GO:0043600
name: replisome (sensu Bacteria and Archaea)
namespace: cellular_component
def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [GOC:jl]
is_a: GO:0030894 ! replisome
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043597 ! replication fork (sensu Bacteria and Archaea)

[Term]
id: GO:0043601
name: replisome (sensu Eukaryota)
namespace: cellular_component
def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jl]
is_a: GO:0030894 ! replisome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043596 ! replication fork (sensu Eukaryota)

[Term]
id: GO:0043614
name: multi-eIF complex
namespace: cellular_component
def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preintiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [SGD:kc]
exact_synonym: "multifactor translation initiation factor (eIF) complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043625
name: delta DNA polymerase complex
namespace: cellular_component
def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]
exact_synonym: "delta-DNA polymerase complex" []
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! replisome (sensu Eukaryota)

[Term]
id: GO:0043626
name: PCNA complex
namespace: cellular_component
def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735]
exact_synonym: "proliferating cell nuclear antigen complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0043655
name: extracellular space of host
namespace: cellular_component
def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [PAMGO:cc]
exact_synonym: "host extracellular space" []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0018995 ! host

[Term]
id: GO:0043656
name: intracellular region of host
namespace: cellular_component
def: "That space within the plasma membrane of a host cell." [PAMGO:cc]
exact_synonym: "host intracellular" []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0043657 ! host cell

[Term]
id: GO:0043657
name: host cell
namespace: cellular_component
def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0018995 ! host

[Term]
id: GO:0043658
name: host symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [PAMGO:cc]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0030430 ! host cell cytoplasm

[Term]
id: GO:0043659
name: symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [PAMGO:cc]
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0043660
name: bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [PAMGO:cc]
is_a: GO:0043659 ! symbiosome

[Term]
id: GO:0043661
name: peribacteroid membrane
namespace: cellular_component
def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [PAMGO:cc]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043662
name: peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [PAMGO:cc]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043663
name: host bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [PAMGO:cc]
is_a: GO:0043658 ! host symbiosome

[Term]
id: GO:0043664
name: host peribacteroid membrane
namespace: cellular_component
def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [PAMGO:cc]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043665
name: host peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [PAMGO:cc]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043667
name: pollen wall
namespace: cellular_component
def: "The complex wall surrounding a pollen grain." [UMSL:fz]
comment: Note that this term is a child of 'extracellular matrix part ; GO:0044420' rather than the more specific 'extracellular matrix (sensu Magnoliophyta) ; GO:0048196', because unlike the usual plant cell wall, the pollen wall does not contain a middle lamella, as specified in the definition of 'extracellular matrix (sensu Magnoliophyta) ; GO:0048196'.
exact_synonym: "micrsopore wall" []
is_a: GO:0044420 ! extracellular matrix part

[Term]
id: GO:0043668
name: exine
namespace: cellular_component
def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the exine is highly resistant to strong acids and bases.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043669
name: ectexine
namespace: cellular_component
def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043670
name: foot layer
namespace: cellular_component
def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/]
exact_synonym: "nexine 1" []
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043669 ! ectexine

[Term]
id: GO:0043671
name: endexine
namespace: cellular_component
def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043672
name: nexine
namespace: cellular_component
def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043673
name: sexine
namespace: cellular_component
def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043674
name: columella
namespace: cellular_component
def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/]
exact_synonym: "sexine 1" []
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043675
name: sculpture element
namespace: cellular_component
def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/]
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043676
name: tectum
namespace: cellular_component
def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/]
exact_synonym: "sexine 2" []
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043677
name: germination pore
namespace: cellular_component
def: "A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [http://en.wikipedia.org/]
exact_synonym: "germ pore" []
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043678
name: intine
namespace: cellular_component
def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043679
name: nerve terminal
namespace: cellular_component
def: "The nerve ending is the structure in which the distal end of the axon of a nerve fiber terminates. Sensory nerve endings are classified as either free or encapsulated. The free nerve ending are the most common type of nerve ending, and are most frequently found in the skin." [GOC:ef]
exact_synonym: "nerve ending" []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0043680
name: filiform apparatus
namespace: cellular_component
def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208]
is_a: GO:0044426 ! cell wall part

[Term]
id: GO:0044420
name: extracellular matrix part
namespace: cellular_component
def: "Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GO:jl]
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0044421
name: extracellular region part
namespace: cellular_component
def: "Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GO:jl]
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0044422
name: organelle part
namespace: cellular_component
def: "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GO:jl]
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0044423
name: virion part
namespace: cellular_component
def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl]
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0019012 ! virion

[Term]
id: GO:0044424
name: intracellular part
namespace: cellular_component
def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0044425
name: membrane part
namespace: cellular_component
def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0044426
name: cell wall part
namespace: cellular_component
def: "Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl]
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0005618 ! cell wall

[Term]
id: GO:0044427
name: chromosomal part
namespace: cellular_component
def: "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl]
subset: gosubset_prok
exact_synonym: "chromosome component" []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0044428
name: nuclear part
namespace: cellular_component
def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl]
exact_synonym: "nucleus component" []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0044429
name: mitochondrial part
namespace: cellular_component
def: "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl]
exact_synonym: "mitochondrion component" []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0044430
name: cytoskeletal part
namespace: cellular_component
def: "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl]
exact_synonym: "cytoskeleton component" []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0044431
name: Golgi apparatus part
namespace: cellular_component
def: "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]
exact_synonym: "Golgi component" []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0044432
name: endoplasmic reticulum part
namespace: cellular_component
def: "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl]
exact_synonym: "ER component" []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0044433
name: cytoplasmic vesicle part
namespace: cellular_component
def: "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0044434
name: chloroplast part
namespace: cellular_component
def: "Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl]
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0044435
name: plastid part
namespace: cellular_component
def: "Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0044436
name: thylakoid part
namespace: cellular_component
def: "Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0044437
name: vacuolar part
namespace: cellular_component
def: "Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl]
subset: gosubset_prok
exact_synonym: "vacuole component" []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0044438
name: microbody part
namespace: cellular_component
def: "Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0042579 ! microbody

[Term]
id: GO:0044439
name: peroxisomal part
namespace: cellular_component
def: "Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl]
exact_synonym: "peroxisome component" []
is_a: GO:0044438 ! microbody part
relationship: part_of GO:0005777 ! peroxisome

[Term]
id: GO:0044440
name: endosomal part
namespace: cellular_component
def: "Any constituent part of an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [GOC:jl]
exact_synonym: "endosome component" []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0044441
name: cilium part
namespace: cellular_component
def: "Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:jl]
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0044442
name: flagellar part (sensu Eukaryota)
namespace: cellular_component
def: "Any constituent part of a flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:jl]
exact_synonym: "flagellum part (sensu Eukaryota)" []
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044460 ! flagellar part
relationship: part_of GO:0009434 ! flagellum (sensu Eukaryota)

[Term]
id: GO:0044443
name: fimbrial part
namespace: cellular_component
def: "Any constituent part of a fimbrium, a proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter." [GOC:jl]
subset: gosubset_prok
exact_synonym: "fimbrium component" []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0009289 ! fimbrium

[Term]
id: GO:0044444
name: cytoplasmic part
namespace: cellular_component
def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl]
subset: gosubset_prok
exact_synonym: "cytoplasm component" []
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044445
name: cytosolic part
namespace: cellular_component
def: "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl]
subset: gosubset_prok
exact_synonym: "cytosol component" []
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0044446
name: intracellular organelle part
namespace: cellular_component
def: "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0044447
name: axoneme part
namespace: cellular_component
def: "Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:jl]
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0044448
name: cell cortex part
namespace: cellular_component
def: "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0044449
name: contractile fiber part
namespace: cellular_component
def: "Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl]
exact_synonym: "contractile fibre component" []
broad_synonym: "muscle fiber component" []
broad_synonym: "muscle fibre component" []
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043292 ! contractile fiber

[Term]
id: GO:0044450
name: microtubule organizing center part
namespace: cellular_component
def: "Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl]
exact_synonym: "microtubule organizing centre component" []
exact_synonym: "MTOC component" []
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005815 ! microtubule organizing center

[Term]
id: GO:0044451
name: nucleoplasm part
namespace: cellular_component
def: "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0044452
name: nucleolar part
namespace: cellular_component
def: "Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl]
exact_synonym: "nucleolus component" []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0044453
name: nuclear membrane part
namespace: cellular_component
def: "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl]
is_a: GO:0044425 ! membrane part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031965 ! nuclear membrane

[Term]
id: GO:0044454
name: nuclear chromosome part
namespace: cellular_component
def: "Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell." [GOC:jl]
is_a: GO:0044427 ! chromosomal part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0044455
name: mitochondrial membrane part
namespace: cellular_component
def: "Any constituent part of the mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl]
is_a: GO:0044425 ! membrane part
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0044456
name: synapse part
namespace: cellular_component
def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl]
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0044457
name: cell septum part
namespace: cellular_component
def: "Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030428 ! cell septum

[Term]
id: GO:0044459
name: plasma membrane part
namespace: cellular_component
def: "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0044460
name: flagellar part
namespace: cellular_component
def: "Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl]
subset: gosubset_prok
exact_synonym: "flagellum component" []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0019861 ! flagellum

[Term]
id: GO:0044461
name: flagellar part (sensu Bacteria)
namespace: cellular_component
def: "Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:jl]
subset: gosubset_prok
exact_synonym: "flagellum part (sensu Bacteria)" []
is_a: GO:0044460 ! flagellar part
relationship: part_of GO:0009288 ! flagellum (sensu Bacteria)

[Term]
id: GO:0044462
name: external encapsulating structure part
namespace: cellular_component
def: "Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030312 ! external encapsulating structure

[Term]
id: GO:0044463
name: cell projection part
namespace: cellular_component
def: "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0044464
name: cell part
namespace: cellular_component
def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005623 ! cell

[Term]
id: GO:0045009
name: chitosome
namespace: cellular_component
def: "An intracellular membrane-bound particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732, PMID:8970154]
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0045025
name: mitochondrial degradosome
namespace: cellular_component
def: "The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts." [PMID:10397341, PMID:9829834]
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0045092
name: interleukin-18 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0045095
name: keratin filament
namespace: cellular_component
def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]
related_synonym: "acidic keratin" []
related_synonym: "basic/neutral keratin" []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045096
name: acidic keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product. To update annotations, use the cellular component term 'keratin filament ; GO:0045095'.
exact_synonym: "type I intermediate filament" []
is_obsolete: true

[Term]
id: GO:0045097
name: basic/neutral keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product. To update annotations, use the cellular component term 'keratin filament ; GO:0045095'.
exact_synonym: "type II intermediate filament" []
is_obsolete: true

[Term]
id: GO:0045098
name: type III intermediate filament
namespace: cellular_component
def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363]
related_synonym: "desmin" []
related_synonym: "glial fibrillary acidic protein" []
related_synonym: "peripherin" []
related_synonym: "type III intermediate filament associated protein" []
related_synonym: "vimentin" []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045099
name: vimentin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product. To update annotations, use the cellular component term 'type III intermediate filament ; GO:0045098'.
is_obsolete: true

[Term]
id: GO:0045100
name: desmin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product. To update annotations, consider the cellular component term 'type III intermediate filament ; GO:0045098'.
is_obsolete: true

[Term]
id: GO:0045101
name: glial fibrillary acidic protein
namespace: cellular_component
def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product. To update annotations, consider the cellular component term 'type III intermediate filament ; GO:0045098'.
exact_synonym: "GFAP" []
is_obsolete: true

[Term]
id: GO:0045102
name: peripherin
namespace: cellular_component
def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product. To update annotations, consider the cellular component term 'type III intermediate filament ; GO:0045098'.
is_obsolete: true

[Term]
id: GO:0045111
name: intermediate filament cytoskeleton
namespace: cellular_component
def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0045120
name: pronucleus
namespace: cellular_component
def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0045121
name: lipid raft
namespace: cellular_component
def: "Specialized membrane domains composed mainly of cholesterol and sphingolipids, and are relatively poor in polyunsaturated lipids such as glycerophospholipids. The formation of these membrane domains is promoted by the presence of cholesterol in the lipid bilayer: the rigid hexagonal rings of cholesterol can pack tightly against the saturated hydrocarbon chains of some membrane lipids, allowing these lipids to assemble into cohesive units floating in the mass of loosely packed polyunsaturated plasma membrane components." [PMID:11880687]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0045160
name: myosin I complex
namespace: cellular_component
def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0045169
name: fusome
namespace: cellular_component
def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045170
name: spectrosome
namespace: cellular_component
def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045171
name: intercellular bridge
namespace: cellular_component
def: "A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells." [PMID:9635420]
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0045172
name: ring canal (sensu Insecta)
namespace: cellular_component
def: "Germline specific intercellular bridge, as in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [PMID:9635420, PMID:9655801]
is_a: GO:0045171 ! intercellular bridge

[Term]
id: GO:0045177
name: apical part of cell
namespace: cellular_component
def: "The apical region of a cell." [GOC:bf]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045178
name: basal part of cell
namespace: cellular_component
def: "The basal region of a cell." [GOC:bf]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045179
name: apical cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0045180
name: basal cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf]
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
exact_synonym: "synaptic junction" []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0045203
name: integral to outer membrane (sensu Proteobacteria)
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the external outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:go_curators]
subset: gosubset_prok
related_synonym: "secretin (sensu Bacteria)" []
exact_synonym: "integral to external membrane (sensu Gram-negative Bacteria)" []
exact_synonym: "integral to external membrane (sensu Proteobacteria)" []
exact_synonym: "integral to outer membrane (sensu Gram-negative bacteria)" []
is_a: GO:0016021 ! integral to membrane
is_a: GO:0031230 ! intrinsic to outer membrane (sensu Proteobacteria)

[Term]
id: GO:0045211
name: postsynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
is_a: GO:0016020 ! membrane
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0045239
name: tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]
subset: gosubset_prok
exact_synonym: "TCA cycle enzyme complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045240
name: alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def: "Complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah]
subset: gosubset_prok
exact_synonym: "2-oxoglutarate dehydrogenase complex" []
exact_synonym: "dihydrolipoyl dehydrogenase complex" []
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045241
name: alpha-ketoglutarate dehydrogenase complex (sensu Bacteria)
namespace: cellular_component
def: "Complex that possesses alpha-ketoglutarate dehydrogenase activity. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
broad_synonym: "2-oxoglutarate dehydrogenase complex" []
is_a: GO:0045240 ! alpha-ketoglutarate dehydrogenase complex
is_a: GO:0045246 ! tricarboxylic acid cycle enzyme complex (sensu Bacteria)

[Term]
id: GO:0045242
name: isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045243
name: isocitrate dehydrogenase complex (NAD+) (sensu Bacteria)
namespace: cellular_component
def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)
is_a: GO:0045246 ! tricarboxylic acid cycle enzyme complex (sensu Bacteria)

[Term]
id: GO:0045244
name: succinate-CoA ligase complex (GDP-forming)
namespace: cellular_component
alt_id: GO:0008325
alt_id: GO:0045245
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain and found in eukaryotes. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl]
narrow_synonym: "succinate-CoA ligase complex (GDP-forming) (sensu Bacteria)" []
narrow_synonym: "succinate-CoA ligase complex (GDP-forming) (sensu Eukaryota)" []
is_a: GO:0030062 ! tricarboxylic acid cycle enzyme complex (sensu Eukaryota)
is_a: GO:0042709 ! succinate-CoA ligase complex

[Term]
id: GO:0045246
name: tricarboxylic acid cycle enzyme complex (sensu Bacteria)
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle, as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
exact_synonym: "TCA cycle enzyme complex (sensu Bacteria)" []
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045247
name: electron transfer flavoprotein complex (sensu Bacteria)
namespace: cellular_component
def: "A protein complex containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0045251 ! electron transfer flavoprotein complex

[Term]
id: GO:0045248
name: oxoglutarate dehydrogenase complex (sensu Bacteria)
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [UniProtKB:Q60597]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0045252 ! oxoglutarate dehydrogenase complex

[Term]
id: GO:0045249
name: pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Bacteria)
namespace: cellular_component
def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [UniProtKB:P35816]
comment: See also the cellular component term 'pyruvate dehydrogenase complex (sensu Bacteria) ; GO:0045250'.
subset: gosubset_prok
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex

[Term]
id: GO:0045250
name: pyruvate dehydrogenase complex (sensu Bacteria)
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0471331309, ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
exact_synonym: "pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)" []
is_a: GO:0045254 ! pyruvate dehydrogenase complex

[Term]
id: GO:0045251
name: electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045252
name: oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [UniProtKB:Q60597]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
exact_synonym: "dihydrolipoamide S-succinyltransferase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045253
name: pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [UniProtKB:P35816]
comment: See also the cellular component term 'pyruvate dehydrogenase complex (sensu Bacteria) ; GO:0045250'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045254
name: pyruvate dehydrogenase complex
namespace: cellular_component
alt_id: GO:0009364
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
exact_synonym: "pyruvate dehydrogenase complex (lipoamide)" []
broad_synonym: "dihydrolipoyl dehydrogenase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045255
name: hydrogen-translocating F-type ATPase complex
namespace: cellular_component
subset: gosubset_prok
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0045256
name: hydrogen-translocating F-type ATPase complex (sensu Bacteria)
namespace: cellular_component
def: "A multisubunit hydrogen-translocating F-type ATPase. F-type ATPases have 2 components, CF(1), the catalytic core, and CF(0), the membrane proton channel. CF(1) has five subunits, alpha(3), beta(3), gamma(1), delta(1), and epsilon(1). CF(0) has three main subunits, a, b and c. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:jic, UniProtKB:P25965]
subset: gosubset_prok
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045255 ! hydrogen-translocating F-type ATPase complex

[Term]
id: GO:0045257
name: succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [ISBN:0198547684, UniProtKB:kd]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045258
name: succinate dehydrogenase complex (ubiquinone) (sensu Bacteria)
namespace: cellular_component
def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0198547684, UniProtKB:kd]
subset: gosubset_prok
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone)

[Term]
id: GO:0045259
name: proton-transporting ATP synthase complex
namespace: cellular_component
def: "The complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation; it catalyzes the hydrolysis of ATP to ADP and orthophosphate." [ISBN:0198547684]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045260
name: proton-transporting ATP synthase complex (sensu Bacteria)
namespace: cellular_component
def: "The complex that catalyzes the phosphorylation of ADP to ATP in the plasma membrane, during oxidative phosphorylation; it catalyzes the hydrolysis of ATP to ADP and orthophosphate. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045261
name: proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, F1 sector" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045262
name: proton-transporting ATP synthase complex, catalytic core F(1) (sensu Bacteria)
namespace: cellular_component
def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah, PMID:10838056]
comment: See also the cellular component term 'plasma membrane ; GO:0005886'.
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, F1 sector (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
relationship: part_of GO:0045260 ! proton-transporting ATP synthase complex (sensu Bacteria)

[Term]
id: GO:0045263
name: proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" []
exact_synonym: "hydrogen-transporting ATP synthase, F0 sector" []
exact_synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045264
name: proton-transporting ATP synthase complex, coupling factor F(o) (sensu Bacteria)
namespace: cellular_component
def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah, PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, F0 sector (sensu Bacteria)" []
exact_synonym: "proton-transporting ATP synthase complex, coupling factor F(0) (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
relationship: part_of GO:0045260 ! proton-transporting ATP synthase complex (sensu Bacteria)

[Term]
id: GO:0045265
name: proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, stator stalk" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0045266
name: proton-transporting ATP synthase, stator stalk (sensu Bacteria)
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, stator stalk (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk
relationship: part_of GO:0045264 ! proton-transporting ATP synthase complex, coupling factor F(o) (sensu Bacteria)

[Term]
id: GO:0045267
name: proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, catalytic core" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045268
name: proton-transporting ATP synthase, catalytic core (sensu Bacteria)
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, catalytic core (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core
relationship: part_of GO:0045262 ! proton-transporting ATP synthase complex, catalytic core F(1) (sensu Bacteria)

[Term]
id: GO:0045269
name: proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, central stalk" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045270
name: proton-transporting ATP synthase, central stalk (sensu Bacteria)
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [PMID:10838056]
subset: gosubset_prok
exact_synonym: "hydrogen-transporting ATP synthase, central stalk (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk
relationship: part_of GO:0045262 ! proton-transporting ATP synthase complex, catalytic core F(1) (sensu Bacteria)

[Term]
id: GO:0045271
name: respiratory chain complex I
namespace: cellular_component
def: "Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. It is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:jic, ISBN:0716749556]
subset: gosubset_prok
exact_synonym: "NADH dehydrogenase (ubiquinone) complex" []
exact_synonym: "NADH-Q oxidoreductase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045272
name: respiratory chain complex I (sensu Bacteria)
namespace: cellular_component
def: "A part of the respiratory chain, containing about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron; the iron undergoes oxidation-reduction between Fe(II) and Fe(III). Catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0198547684]
subset: gosubset_prok
exact_synonym: "NADH dehydrogenase (ubiquinone) complex (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045271 ! respiratory chain complex I

[Term]
id: GO:0045273
name: respiratory chain complex II
namespace: cellular_component
def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045274
name: respiratory chain complex II (sensu Bacteria)
namespace: cellular_component
def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045273 ! respiratory chain complex II

[Term]
id: GO:0045275
name: respiratory chain complex III
namespace: cellular_component
def: "A part of the respiratory chain, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [ISBN:0198547684]
subset: gosubset_prok
exact_synonym: "ubiquinol-cytochrome c oxidoreductase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045276
name: respiratory chain complex III (sensu Bacteria)
namespace: cellular_component
def: "A part of the respiratory chain, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0198547684]
subset: gosubset_prok
exact_synonym: "ubiquinol-cytochrome c oxidoreductase complex (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045275 ! respiratory chain complex III

[Term]
id: GO:0045277
name: respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045287
def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]
subset: gosubset_prok
exact_synonym: "cytochrome c oxidase complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045278
name: respiratory chain complex IV (sensu Bacteria)
namespace: cellular_component
alt_id: GO:0045288
def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0198547684]
subset: gosubset_prok
exact_synonym: "cytochrome c oxidase complex (sensu Bacteria)" []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045277 ! respiratory chain complex IV

[Term]
id: GO:0045279
name: NADH dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "Complex that possesses NADH dehydrogenase (ubiquinone) activity." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'.
subset: gosubset_prok
is_a: GO:0030964 ! NADH dehydrogenase complex (quinone)
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045271 ! respiratory chain complex I

[Term]
id: GO:0045280
name: NADH dehydrogenase complex (ubiquinone) (sensu Bacteria)
namespace: cellular_component
def: "Complex that possesses NADH dehydrogenase (ubiquinone) activity, as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030966 ! NADH dehydrogenase complex (quinone) (sensu Bacteria)
is_a: GO:0045279 ! NADH dehydrogenase complex (ubiquinone)

[Term]
id: GO:0045281
name: succinate dehydrogenase complex
namespace: cellular_component
def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [InterPro:IPR000701, UniProtKB:kd]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045273 ! respiratory chain complex II

[Term]
id: GO:0045282
name: succinate dehydrogenase complex (sensu Bacteria)
namespace: cellular_component
def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [InterPro:IPR000701, UniProtKB:kd]
subset: gosubset_prok
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045281 ! succinate dehydrogenase complex
relationship: part_of GO:0045274 ! respiratory chain complex II (sensu Bacteria)

[Term]
id: GO:0045283
name: fumarate reductase complex
namespace: cellular_component
def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:004224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045273 ! respiratory chain complex II

[Term]
id: GO:0045284
name: fumarate reductase complex (sensu Bacteria)
namespace: cellular_component
def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:00224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
subset: gosubset_prok
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045283 ! fumarate reductase complex
relationship: part_of GO:0045274 ! respiratory chain complex II (sensu Bacteria)

[Term]
id: GO:0045285
name: ubiquinol-cytochrome-c reductase complex
namespace: cellular_component
def: "An enzyme complex that contains cytochrome b/b6 and cytochrome c1." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045275 ! respiratory chain complex III

[Term]
id: GO:0045286
name: ubiquinol-cytochrome-c reductase complex (sensu Bacteria)
namespace: cellular_component
def: "An enzyme complex that contains cytochrome b/b6 and cytochrome c1. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045285 ! ubiquinol-cytochrome-c reductase complex
relationship: part_of GO:0045276 ! respiratory chain complex III (sensu Bacteria)

[Term]
id: GO:0045293
name: mRNA editing complex
namespace: cellular_component
def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607]
exact_synonym: "editosome" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045298
name: tubulin complex
namespace: cellular_component
def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [http://cancerweb.ncl.ac.uk/, ISBN:0716731363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005874 ! microtubule

[Term]
id: GO:0045320
name: hydrogen-translocating F-type ATPase complex (sensu Viridiplantae)
namespace: cellular_component
def: "A multisubunit hydrogen-translocating F-type ATPase. F-type ATPases have 2 components, CF(1), the catalytic core, and CF(0), the membrane proton channel. CF(1) has five subunits, alpha(3), beta(3), gamma(1), delta(1), and epsilon(1). CF(0) has three main subunits, a, b and c. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [GOC:jic, UniProtKB:P60112]
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0045255 ! hydrogen-translocating F-type ATPase complex
relationship: part_of GO:0009535 ! thylakoid membrane (sensu Viridiplantae)

[Term]
id: GO:0045323
name: interleukin-1 receptor complex
namespace: cellular_component
def: "Complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0045334
name: clathrin-coated endocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045335
name: phagocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
exact_synonym: "phagosome" []
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045336
name: clathrin-coated phagocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
exact_synonym: "clathrin-coated phagosome" []
is_a: GO:0045334 ! clathrin-coated endocytic vesicle
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0045495
name: pole plasm
namespace: cellular_component
def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kva, http://cancerweb.ncl.ac.uk/]
exact_synonym: "polar plasm" []
narrow_synonym: "germ plasm" []
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0046536
name: dosage compensation complex
namespace: cellular_component
def: "A protein or protein-RNA complex that localizes\nto one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kva, GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046540
name: U4/U6 x U5 tri-snRNP complex
namespace: cellular_component
def: "A complex composed of three small nuclear ribonucleoproteins, snRNP U4, snRNP U6 and snRNP U5." [PMID:11867543]
exact_synonym: "U4/U6 . U5 snRNP complex" []
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0046581
name: intercellular canaliculus
namespace: cellular_component
def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544]
is_a: GO:0005911 ! intercellular junction

[Term]
id: GO:0046610
name: lysosomal hydrogen-transporting ATPase V0 domain
namespace: cellular_component
is_a: GO:0000220 ! hydrogen-transporting ATPase V0 domain
is_a: GO:0046611 ! lysosomal hydrogen-translocating V-type ATPase complex

[Term]
id: GO:0046611
name: lysosomal hydrogen-translocating V-type ATPase complex
namespace: cellular_component
broad_synonym: "lysosomal membrane hydrogen-transporting ATPase" []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
is_a: GO:0016471 ! hydrogen-translocating V-type ATPase complex
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0046612
name: lysosomal hydrogen-transporting ATPase V1 domain
namespace: cellular_component
is_a: GO:0000221 ! hydrogen-transporting ATPase V1 domain
is_a: GO:0046611 ! lysosomal hydrogen-translocating V-type ATPase complex

[Term]
id: GO:0046658
name: anchored to plasma membrane
namespace: cellular_component
def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah]
related_synonym: "GPI-linked ephrin" []
narrow_synonym: "plasma membrane, GPI-anchored" []
is_a: GO:0031225 ! anchored to membrane
is_a: GO:0031226 ! intrinsic to plasma membrane

[Term]
id: GO:0046691
name: intracellular canaliculus
namespace: cellular_component
def: "A narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [ISBN:0721662544, PMID:10700045]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0046695
name: SLIK (SAGA-like) complex
namespace: cellular_component
def: "A protein complex similar to the SAGA complex but with a smaller form of Spt7 and no Spt8. Although little is known about the SLIK complex, evidence suggests involvement of the general amino acid control pathway." [PMID:12101232, PMID:12186975]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
exact_synonym: "SAGA (alt) complex" []
exact_synonym: "SALSA complex" []
exact_synonym: "SLIK/SALSA complex" []
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0046696
name: lipopolysaccharide receptor complex
namespace: cellular_component
def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated." [PMID:11706042]
comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of.
exact_synonym: "LPS receptor complex" []
is_a: GO:0016021 ! integral to membrane
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0046727
name: capsomere
namespace: cellular_component
def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732]
exact_synonym: "capsomer" []
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046728
name: viral capsid (sensu Retroviridae)
namespace: cellular_component
def: "The protein coat that surrounds the viral nucleocapsid, which in turn encapsulates the infective nucleic acid in retrovirus particles; the structure is complex, and specific structures and functions are associated with different elements of the capsid. As in, but not restricted to, the Retroviridae (Retroviridae, ncbi_taxonomy_id:11632)." [ISBN:0122270304, ISBN:1555811272]
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0046729
name: viral procapsid
namespace: cellular_component
def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0046798
name: viral portal complex
namespace: cellular_component
def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732]
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046806
name: viral scaffold
namespace: cellular_component
def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319]
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046808
name: assemblon
namespace: cellular_component
def: "Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046809
name: replication compartment
namespace: cellular_component
def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046816
name: virion transport vesicle
namespace: cellular_component
def: "A vesicle used to transport the partial or complete virion between cellular compartments." [PMID:7933124]
is_a: GO:0031982 ! vesicle
is_a: GO:0043231 ! intracellular membrane-bound organelle

[Term]
id: GO:0046818
name: dense nuclear body
namespace: cellular_component
def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046821
name: extrachromosomal DNA
namespace: cellular_component
def: "DNA structures that are not part of a chromosome." [GOC:ai]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0046858
name: chlorosome
namespace: cellular_component
def: "A small compartment found in photosynthetic Chlorobiaceae bacteria. It contains bacteriochlorophyll c and is attached to the cytoplasmic membrane." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0046859
name: hydrogenosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai]
exact_synonym: "hydrogenosome membrane" []
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0042566 ! hydrogenosome

[Term]
id: GO:0046860
name: glycosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glycosome." [GOC:ai]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0020015 ! glycosome

[Term]
id: GO:0046861
name: glyoxysomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai]
exact_synonym: "glyoxysome membrane" []
is_a: GO:0031903 ! microbody membrane
is_a: GO:0044438 ! microbody part
relationship: part_of GO:0009514 ! glyoxysome

[Term]
id: GO:0046862
name: chromoplast membrane
namespace: cellular_component
def: "The membrane surrounding a chromoplast." [GOC:ai]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0046868
name: mesosome
namespace: cellular_component
def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732, ISBN:0716731363986]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0046930
name: pore complex
namespace: cellular_component
def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732]
subset: gosubset_prok
related_synonym: "channel-forming toxin activity" []
related_synonym: "colicin" []
related_synonym: "pore-forming toxin activity" []
exact_synonym: "pore" []
is_a: GO:0016021 ! integral to membrane

[Term]
id: GO:0048046
name: apoplast
namespace: cellular_component
def: "The protoplasts of cells in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jic]
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0048179
name: activin receptor complex
namespace: cellular_component
def: "Activin receptors can be type I or type II and are cell surface transmembrane receptors with serine/threonine activity." [GOC:jic, ISBN:0121551423]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0048180
name: activin complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0048181
name: activin A complex
namespace: cellular_component
def: "OBSOLETE. A homodimer of inhibin beta-A is termed 'activin A complex'. This protein complex is secreted." [GOC:jic, http://www.mercksource.com, http://www.stedmans.com/]
comment: This term was made obsolete because it represents a homodimer; GO cellular component terms must represent complexes containing more than one gene product.
exact_synonym: "inhibin beta-A" []
is_obsolete: true

[Term]
id: GO:0048182
name: activin B complex
namespace: cellular_component
def: "OBSOLETE. A homodimer of inhibin beta-B is termed 'activin B complex'. This protein complex is secreted." [GOC:jic, http://www.mercksource.com, http://www.stedmans.com/]
comment: This term was made obsolete because it represents a homodimer; GO cellular component terms must represent complexes containing more than one gene product.
exact_synonym: "inhibin beta-B" []
is_obsolete: true

[Term]
id: GO:0048183
name: activin AB complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
narrow_synonym: "inhibin beta-A" []
narrow_synonym: "inhibin beta-B" []
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0048188
name: COMPASS complex
namespace: cellular_component
def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p." [PMID:11687631, PMID:11805083]
narrow_synonym: "Set1 complex" []
narrow_synonym: "Set1C" []
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0048189
name: Lid2 complex
namespace: cellular_component
def: "A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." [PMID:12488447]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0048196
name: extracellular matrix (sensu Magnoliophyta)
namespace: cellular_component
def: "The matrix external to the cell, composed of the cell wall and middle lamella. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:jic, http://cancerweb.ncl.ac.uk]
comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell.
is_a: GO:0030312 ! external encapsulating structure
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0048217
name: pectic matrix
namespace: cellular_component
def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048222
name: glycoprotein network
namespace: cellular_component
def: "A network of glycoproteins; proteins with covalently attached sugar units, either bonded via the hydroxyl group of serine or threonine (O glycosylated) or through the amino terminal of asparagine (N glycosylated)." [GOC:jic, http://cancerweb.ncl.ac.uk]
exact_synonym: "extensin" []
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009530 ! primary cell wall

[Term]
id: GO:0048223
name: hemicellulose network
namespace: cellular_component
def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048224
name: lignin network
namespace: cellular_component
def: "A network composed of lignin; a complex polymer of phenylpropanoid subunits, laid down in the walls of plant cells such as xylem vessels and sclerenchyma. It imparts considerable strength to the wall and also protects it against degradation by microorganisms. It is also laid down as a defence reaction against pathogenic attack, as part of the hypersensitive response of plants." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048225
name: suberin network
namespace: cellular_component
def: "Fatty substance, containing long chain fatty acids and fatty esters, found in the cell walls of cork cells (phellem) in higher plants. Renders the cell wall impervious to water." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048226
name: Casparian strip
namespace: cellular_component
def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048237
name: rough endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jic]
exact_synonym: "rough ER lumen" []
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0048238
name: smooth endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jic]
exact_synonym: "smooth ER lumen" []
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0048269
name: methionine adenosyltransferase complex
namespace: cellular_component
def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jic, PMID:10644686]
exact_synonym: "MAT complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0048353
name: primary endosperm nucleus
namespace: cellular_component
def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048471
name: perinuclear region
namespace: cellular_component
def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jic]
comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'.
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048475
name: coated membrane
namespace: cellular_component
def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jic]
is_a: GO:0016020 ! membrane

[Term]
id: GO:0048476
name: Holliday junction resolvase complex
namespace: cellular_component
def: "An endonuclease complex that resolves Holliday junctions by a nick and counternick mechanism." [GOC:vw, PMID:14527419]
narrow_synonym: "Mus81-Eme1 complex" []
is_a: GO:0005941 ! unlocalized protein complex

[Term]
id: GO:0048492
name: ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg]
subset: gosubset_prok
exact_synonym: "RubisCO complex" []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048493
name: ribulose bisphosphate carboxylase complex (sensu Cyanobacteria)
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. As in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117)." [GOC:mlg]
subset: gosubset_prok
exact_synonym: "RubisCO complex (sensu Cyanobacteria)" []
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
relationship: part_of GO:0030075 ! thylakoid (sensu Cyanobacteria)

[Term]
id: GO:0048494
name: ribulose bisphosphate carboxylase complex (sensu Proteobacteria, Chloroflexaceae and Chlorobiaceae)
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. As in, but not restricted to: the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224), the filamentous anoxygenic phototrophic bacteria (Chloroflexaceae, ncbi_taxonomy_id:1106), and the green sulfur bacteria (Chlorobiaceae, ncbi_taxonomy_id:191412)." [GOC:mlg]
subset: gosubset_prok
exact_synonym: "RubisCO complex (sensu Proteobacteria)" []
is_a: GO:0042716 ! chromatophore
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex

[Term]
id: GO:0048500
name: signal recognition particle
namespace: cellular_component
def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048501
name: signal recognition particle (sensu Bacteria and Archaea)
namespace: cellular_component
def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157)." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0048555
name: generative cell nucleus
namespace: cellular_component
def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators]
related_synonym: "sperm cell nucleus (sensu Magnoliophyta)" []
exact_synonym: "male germ cell nucleus (sensu Magnoliophyta)" []
is_a: GO:0001673 ! male germ cell nucleus

[Term]
id: GO:0048556
name: microsporocyte nucleus
namespace: cellular_component
def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X]
exact_synonym: "microspore mother cell nucleus" []
exact_synonym: "pollen mother cell nucleus" []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048770
name: pigment granule
namespace: cellular_component
def: "A small, subcellular membrane-bound vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jic, GOC:mh]
is_a: GO:0016023 ! cytoplasmic membrane-bound vesicle

[Term]
id: GO:0048786
name: presynaptic active zone
namespace: cellular_component
def: "A specialized presynaptic plasma membrane region where synaptic vesicles dock and fuse." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:3152289]
is_a: GO:0043232 ! intracellular non-membrane-bound organelle
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0048787
name: active zone presynaptic plasma membrane
namespace: cellular_component
def: "The active zone is a specialized site of the presynaptic plasma membrane where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289]
exact_synonym: "CAZ plasma membrane" []
is_a: GO:0042734 ! presynaptic membrane

[Term]
id: GO:0048788
name: presynaptic cytoskeletal matrix assembled at active zones
namespace: cellular_component
def: "The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:10944438]
exact_synonym: "presynaptic cytomatrix assembled at active zones" []
narrow_synonym: "CAZ" []
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0051077
name: secondary cell septum (sensu Fungi)
namespace: cellular_component
def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [PMID:15194814]
exact_synonym: "secondary septum (sensu Fungi)" []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0051233
name: spindle midzone
namespace: cellular_component
def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
exact_synonym: "spindle equator" []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0051285
name: cell cortex of cell tip
namespace: cellular_component
def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai]
exact_synonym: "cell cortex of cell end" []
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0051286
name: cell tip
namespace: cellular_component
def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth may occur." [GOC:ai, GOC:vw]
exact_synonym: "cell end" []
is_a: GO:0030427 ! site of polarized growth

[Typedef]
id: part_of
name: part of
is_transitive: true